Speg SPEG complex locus [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spegprovided by MGI
Official Full Name: SPEG complex locusprovided by MGI
Primary source: MGI:MGI:109282
See related: Ensembl:ENSMUSG00000026207 AllianceGenome:MGI:109282
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BPEG; Apeg1; APEG-1; SPEGbeta; SPEGalpha; mKIAA1297; D1Bwg1450e
Summary: This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Studies have determined that a lack of this protein affected myocardial development. Multiple alternatively spliced transcript variants that encode different protein isoforms have been defined. [provided by RefSeq, Mar 2010]
Expression: Broad expression in heart adult (RPKM 14.9), cortex adult (RPKM 9.1) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C4; 1 38.88 cM

Exon count:: 50

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (75351931..75408964)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (75375297..75432320)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes.
Title: Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes.
Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads.
Title: Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads.
SPEG binds with desmin and its deficiency causes defects in triad and focal adhesion proteins.
Title: SPEG binds with desmin and its deficiency causes defects in triad and focal adhesion proteins.
Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation.
Title: Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation.
Striated Preferentially Expressed Protein Kinase (SPEG)-Deficient Skeletal Muscles Display Fewer Satellite Cells with Reduced Proliferation and Delayed Differentiation.
Title: Striated Preferentially Expressed Protein Kinase (SPEG)-Deficient Skeletal Muscles Display Fewer Satellite Cells with Reduced Proliferation and Delayed Differentiation.
Data indicate that insulin resistance impairs this protein kinase B (PKB)-Striated muscle preferentially expressed protein kinase (SPEG)-sarcoplasmic/endoplasmic reticulum calcium-ATPase 2a (SERCA2a) signal axis, which contributes to the development of diabetic cardiomyopathy.
Title: A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis.
The 2 kinase-domains of SPEG may play distinct roles to regulate cardiac function. The second kinase-domain of SPEG is a critical regulator for SERCA2a and controls calcium reuptake into the sarcoplasmic reticulum.
Title: SPEG Controls Calcium Reuptake Into the Sarcoplasmic Reticulum Through Regulating SERCA2a by Its Second Kinase-Domain.
Acute loss of SPEG in hearts causes junctophilin-2 de-phosphorylation leading to heart failure.
Title: SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity.
Disruption of the striated preferentially expressed gene (Speg) locus leads to cardiac dysfunction and a phenotype consistent with dilated cardiomyopathy.
Title: Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128701 (e-PCR)
- UniSTS:212009

N28140 (e-PCR)
- UniSTS:125501

RH125059 (e-PCR)
- UniSTS:161881

U57098 (e-PCR)
- UniSTS:185440

D1Bwg1450e (e-PCR), detects polymorphism
- UniSTS:142231

RH139048 (e-PCR)
- UniSTS:221134

AW125581 (e-PCR)
- UniSTS:178414

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within circulatory system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: striated muscle-specific serine/threonine-protein kinase

Names: aortic preferentially expressed gene 1; aortic preferentially expressed protein 1

NP_001078839.1

EC 2.7.11.1

NP_001078840.1

EC 2.7.11.1

NP_001166948.1

EC 2.7.11.1

NP_031489.4

EC 2.7.11.1

XP_006496464.1

EC 2.7.11.1

XP_006496465.1

EC 2.7.11.1

XP_006496466.1

EC 2.7.11.1

XP_006496467.1

EC 2.7.11.1

XP_011236945.1

EC 2.7.11.1

XP_011236946.1

EC 2.7.11.1

XP_011236947.1

EC 2.7.11.1

XP_011236948.1

EC 2.7.11.1

XP_011236949.1

EC 2.7.11.1

XP_011236950.1

EC 2.7.11.1

XP_011236951.1

EC 2.7.11.1

XP_011236953.1

EC 2.7.11.1

XP_017167765.1

EC 2.7.11.1

XP_017177843.1

EC 2.7.11.1

XP_017177864.1

EC 2.7.11.1

XP_030099133.1

EC 2.7.11.1

XP_030099208.1

EC 2.7.11.1

XP_030099228.1

EC 2.7.11.1

XP_030099250.1

EC 2.7.11.1

XP_030099262.1

EC 2.7.11.1

XP_030099307.1

EC 2.7.11.1

XP_030099336.1

EC 2.7.11.1

XP_030099354.1

EC 2.7.11.1

XP_030099372.1

EC 2.7.11.1

XP_030099381.1

EC 2.7.11.1

XP_036010913.1

EC 2.7.11.1

XP_036011038.1

EC 2.7.11.1

XP_036011068.1

EC 2.7.11.1

XP_036011090.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085370.2 → NP_001078839.1 striated muscle-specific serine/threonine-protein kinase isoform 2

See identical proteins and their annotated locations for NP_001078839.1

Status: VALIDATED

Source sequence(s)

AC114651

UniProtKB/TrEMBL

A0A087WSE3

Related

ENSMUSP00000141009.2, ENSMUST00000137868.8

Conserved Domains (8) summary

PHA03247
Location:1206 → 1610

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1490 → 1812

PHA03307; transcriptional regulator ICP4; Provisional

cd00063
Location:1946 → 2032

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14108
Location:868 → 1124

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

cd14111
Location:2222 → 2478

STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:82 → 138

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:755 → 844

I-set; Immunoglobulin I-set domain

cl11960
Location:243 → 328

Ig; Immunoglobulin domain
NM_001085371.2 → NP_001078840.1 striated muscle-specific serine/threonine-protein kinase isoform 3

See identical proteins and their annotated locations for NP_001078840.1

Status: VALIDATED

Source sequence(s)

AC114651

Consensus CDS

CCDS48292.1

UniProtKB/Swiss-Prot

Q62407

Related

ENSMUSP00000109220.2, ENSMUST00000113590.8

Conserved Domains (4) summary

smart00408
Location:781 → 848

IGc2; Immunoglobulin C-2 Type

pfam07679
Location:621 → 710

I-set; Immunoglobulin I-set domain

pfam16650
Location:711 → 767

SPEG_u2; Unstructured region on SPEG complex protein

cl11960
Location:638 → 710

Ig; Immunoglobulin domain
NM_001173477.2 → NP_001166948.1 striated muscle-specific serine/threonine-protein kinase isoform 4

See identical proteins and their annotated locations for NP_001166948.1

Status: VALIDATED

Source sequence(s)

AC114651

Consensus CDS

CCDS48293.1

UniProtKB/TrEMBL

A0A0R4J1J0

Related

ENSMUSP00000109219.2, ENSMUST00000113589.8

Conserved Domains (1) summary

cd20975
Location:20 → 110

IgI_APEG-1_like; Immunoglobulin-like domain of human Aortic Preferentially Expressed Protein-1 (APEG-1) and similar proteins; a member of the I-set of IgSF domains
NM_007463.5 → NP_031489.4 striated muscle-specific serine/threonine-protein kinase isoform 1

Status: VALIDATED

Source sequence(s)

AC114651, AC161346

Consensus CDS

CCDS35626.1

UniProtKB/Swiss-Prot

Q3TPH8, Q62407, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5

UniProtKB/TrEMBL

E9QQ25

Related

ENSMUSP00000084361.6, ENSMUST00000087122.12

Conserved Domains (8) summary

cd00096
Location:62 → 124

Ig; Immunoglobulin domain

smart00408
Location:1082 → 1148

IGc2; Immunoglobulin C-2 Type

smart00220
Location:2961 → 3213

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam07679
Location:727 → 816

I-set; Immunoglobulin I-set domain

cd14108
Location:1603 → 1859

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

cd14111
Location:2957 → 3213

STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:817 → 873

SPEG_u2; Unstructured region on SPEG complex protein

cl11960
Location:744 → 816

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

75351931..75408964

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155020.1 → XP_036010913.1 striated muscle-specific serine/threonine-protein kinase isoform X11

Conserved Domains (9) summary

smart00410
Location:1414 → 1495

IG_like; Immunoglobulin like

PHA03247
Location:320 → 725

PHA03247; large tegument protein UL36; Provisional

cd00063
Location:1297 → 1374

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14108
Location:1613 → 1869

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:827 → 883

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:737 → 826

I-set; Immunoglobulin I-set domain

cd00096
Location:1079 → 1082

Ig; Ig strand A [structural motif]

cd20975
Location:884 → 974

IgI_APEG-1_like; Immunoglobulin-like domain of human Aortic Preferentially Expressed Protein-1 (APEG-1) and similar proteins; a member of the I-set of IgSF domains

cl11960
Location:1079 → 1168

Ig; Immunoglobulin domain
XM_011238643.3 → XP_011236945.1 striated muscle-specific serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

Q3TPH8, Q62407, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5

Conserved Domains (8) summary

PHA03247
Location:1951 → 2355

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2235 → 2557

PHA03307; transcriptional regulator ICP4; Provisional

cd00063
Location:2691 → 2777

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14108
Location:1613 → 1869

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

cd14111
Location:2967 → 3223

STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:827 → 883

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:737 → 826

I-set; Immunoglobulin I-set domain

cl11960
Location:988 → 1073

Ig; Immunoglobulin domain
XM_011238644.3 → XP_011236946.1 striated muscle-specific serine/threonine-protein kinase isoform X2

UniProtKB/Swiss-Prot

Q3TPH8, Q62407, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5

Conserved Domains (8) summary

PHA03247
Location:1892 → 2296

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2176 → 2498

PHA03307; transcriptional regulator ICP4; Provisional

cd00063
Location:2632 → 2718

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14108
Location:1554 → 1810

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

cd14111
Location:2908 → 3164

STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:768 → 824

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:678 → 767

I-set; Immunoglobulin I-set domain

cl11960
Location:929 → 1014

Ig; Immunoglobulin domain
XM_011238651.3 → XP_011236953.1 striated muscle-specific serine/threonine-protein kinase isoform X13

Conserved Domains (3) summary

PHA03247
Location:320 → 678

PHA03247; large tegument protein UL36; Provisional

pfam16650
Location:827 → 883

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:737 → 826

I-set; Immunoglobulin I-set domain
XM_030243368.2 → XP_030099228.1 striated muscle-specific serine/threonine-protein kinase isoform X14

Conserved Domains (3) summary

PHA03247
Location:261 → 619

PHA03247; large tegument protein UL36; Provisional

pfam16650
Location:768 → 824

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:678 → 767

I-set; Immunoglobulin I-set domain
XM_030243273.2 → XP_030099133.1 striated muscle-specific serine/threonine-protein kinase isoform X8

UniProtKB/TrEMBL

A0A087WSE3

Conserved Domains (8) summary

PHA03247
Location:1206 → 1610

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1490 → 1812

PHA03307; transcriptional regulator ICP4; Provisional

cd00063
Location:1946 → 2032

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14108
Location:868 → 1124

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

cd14111
Location:2222 → 2478

STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:82 → 138

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:755 → 844

I-set; Immunoglobulin I-set domain

cl11960
Location:243 → 328

Ig; Immunoglobulin domain
XM_017322354.3 → XP_017177843.1 striated muscle-specific serine/threonine-protein kinase isoform X3

UniProtKB/Swiss-Prot

Q3TPH8, Q62407, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5

Conserved Domains (8) summary

PHA03247
Location:1885 → 2289

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2169 → 2491

PHA03307; transcriptional regulator ICP4; Provisional

cd00063
Location:2625 → 2711

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14108
Location:1547 → 1803

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:761 → 817

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:671 → 760

I-set; Immunoglobulin I-set domain

cl11960
Location:922 → 1007

Ig; Immunoglobulin domain

cl21453
Location:2901 → 3157

PKc_like; Protein Kinases, catalytic domain
XM_017322375.3 → XP_017177864.1 striated muscle-specific serine/threonine-protein kinase isoform X6

UniProtKB/TrEMBL

A0A087WSE3

Conserved Domains (8) summary

PHA03247
Location:1826 → 2230

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2110 → 2432

PHA03307; transcriptional regulator ICP4; Provisional

cd00063
Location:2566 → 2652

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14108
Location:1488 → 1744

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:702 → 758

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:612 → 701

I-set; Immunoglobulin I-set domain

cl11960
Location:863 → 948

Ig; Immunoglobulin domain

cl21453
Location:2842 → 3098

PKc_like; Protein Kinases, catalytic domain
XM_011238645.3 → XP_011236947.1 striated muscle-specific serine/threonine-protein kinase isoform X4

UniProtKB/Swiss-Prot

Q3TPH8, Q62407, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5

Conserved Domains (8) summary

PHA03247
Location:1845 → 2249

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2129 → 2451

PHA03307; transcriptional regulator ICP4; Provisional

cd00063
Location:2585 → 2671

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14108
Location:1507 → 1763

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:721 → 777

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:631 → 720

I-set; Immunoglobulin I-set domain

cl11960
Location:882 → 967

Ig; Immunoglobulin domain

cl21453
Location:2861 → 3117

PKc_like; Protein Kinases, catalytic domain
XM_011238647.3 → XP_011236949.1 striated muscle-specific serine/threonine-protein kinase isoform X7

UniProtKB/TrEMBL

A0A087WSE3

Conserved Domains (8) summary

PHA03247
Location:1786 → 2190

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2070 → 2392

PHA03307; transcriptional regulator ICP4; Provisional

cd00063
Location:2526 → 2612

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14108
Location:1448 → 1704

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:662 → 718

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:572 → 661

I-set; Immunoglobulin I-set domain

cl11960
Location:823 → 908

Ig; Immunoglobulin domain

cl21453
Location:2802 → 3058

PKc_like; Protein Kinases, catalytic domain
XM_030243402.2 → XP_030099262.1 striated muscle-specific serine/threonine-protein kinase isoform X16

Conserved Domains (3) summary

PHA03247
Location:214 → 572

PHA03247; large tegument protein UL36; Provisional

pfam16650
Location:721 → 777

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:631 → 720

I-set; Immunoglobulin I-set domain
XM_030243447.2 → XP_030099307.1 striated muscle-specific serine/threonine-protein kinase isoform X18

Conserved Domains (3) summary

PHA03247
Location:155 → 513

PHA03247; large tegument protein UL36; Provisional

pfam16650
Location:662 → 718

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:572 → 661

I-set; Immunoglobulin I-set domain
XM_036155145.1 → XP_036011038.1 striated muscle-specific serine/threonine-protein kinase isoform X19

Conserved Domains (4) summary

pfam16650
Location:82 → 138

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:1 → 81

I-set; Immunoglobulin I-set domain

cd00096
Location:9 → 17

Ig; Ig strand B [structural motif]

cd20975
Location:139 → 229

IgI_APEG-1_like; Immunoglobulin-like domain of human Aortic Preferentially Expressed Protein-1 (APEG-1) and similar proteins; a member of the I-set of IgSF domains
XM_030243390.2 → XP_030099250.1 striated muscle-specific serine/threonine-protein kinase isoform X15

Conserved Domains (3) summary

PHA03247
Location:254 → 612

PHA03247; large tegument protein UL36; Provisional

pfam16650
Location:761 → 817

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:671 → 760

I-set; Immunoglobulin I-set domain
XM_017312276.3 → XP_017167765.1 striated muscle-specific serine/threonine-protein kinase isoform X17

Conserved Domains (3) summary

PHA03247
Location:195 → 553

PHA03247; large tegument protein UL36; Provisional

pfam16650
Location:702 → 758

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:612 → 701

I-set; Immunoglobulin I-set domain
XM_030243512.2 → XP_030099372.1 striated muscle-specific serine/threonine-protein kinase isoform X19

Conserved Domains (4) summary

pfam16650
Location:82 → 138

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:1 → 81

I-set; Immunoglobulin I-set domain

cd00096
Location:9 → 17

Ig; Ig strand B [structural motif]

cd20975
Location:139 → 229

IgI_APEG-1_like; Immunoglobulin-like domain of human Aortic Preferentially Expressed Protein-1 (APEG-1) and similar proteins; a member of the I-set of IgSF domains
XM_011238648.4 → XP_011236950.1 striated muscle-specific serine/threonine-protein kinase isoform X8

See identical proteins and their annotated locations for XP_011236950.1

UniProtKB/TrEMBL

A0A087WSE3

Conserved Domains (8) summary

PHA03247
Location:1206 → 1610

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1490 → 1812

PHA03307; transcriptional regulator ICP4; Provisional

cd00063
Location:1946 → 2032

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14108
Location:868 → 1124

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

cd14111
Location:2222 → 2478

STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:82 → 138

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:755 → 844

I-set; Immunoglobulin I-set domain

cl11960
Location:243 → 328

Ig; Immunoglobulin domain
XM_011238646.3 → XP_011236948.1 striated muscle-specific serine/threonine-protein kinase isoform X5

UniProtKB/Swiss-Prot

Q3TPH8, Q62407, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5

Conserved Domains (8) summary

PHA03247
Location:1835 → 2239

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2119 → 2441

PHA03307; transcriptional regulator ICP4; Provisional

cd00063
Location:2575 → 2661

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14108
Location:1497 → 1753

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:711 → 767

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:621 → 710

I-set; Immunoglobulin I-set domain

cl11960
Location:872 → 957

Ig; Immunoglobulin domain

cl21453
Location:2851 → 3107

PKc_like; Protein Kinases, catalytic domain
XM_030243494.1 → XP_030099354.1 striated muscle-specific serine/threonine-protein kinase isoform X19

Conserved Domains (4) summary

pfam16650
Location:82 → 138

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:1 → 81

I-set; Immunoglobulin I-set domain

cd00096
Location:9 → 17

Ig; Ig strand B [structural motif]

cd20975
Location:139 → 229

IgI_APEG-1_like; Immunoglobulin-like domain of human Aortic Preferentially Expressed Protein-1 (APEG-1) and similar proteins; a member of the I-set of IgSF domains
XM_030243521.1 → XP_030099381.1 striated muscle-specific serine/threonine-protein kinase isoform X19

Conserved Domains (4) summary

pfam16650
Location:82 → 138

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:1 → 81

I-set; Immunoglobulin I-set domain

cd00096
Location:9 → 17

Ig; Ig strand B [structural motif]

cd20975
Location:139 → 229

IgI_APEG-1_like; Immunoglobulin-like domain of human Aortic Preferentially Expressed Protein-1 (APEG-1) and similar proteins; a member of the I-set of IgSF domains
XM_006496401.3 → XP_006496464.1 striated muscle-specific serine/threonine-protein kinase isoform X8

See identical proteins and their annotated locations for XP_006496464.1

UniProtKB/TrEMBL

A0A087WSE3

Conserved Domains (8) summary

PHA03247
Location:1206 → 1610

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1490 → 1812

PHA03307; transcriptional regulator ICP4; Provisional

cd00063
Location:1946 → 2032

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14108
Location:868 → 1124

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

cd14111
Location:2222 → 2478

STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:82 → 138

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:755 → 844

I-set; Immunoglobulin I-set domain

cl11960
Location:243 → 328

Ig; Immunoglobulin domain
XM_011238649.4 → XP_011236951.1 striated muscle-specific serine/threonine-protein kinase isoform X8

See identical proteins and their annotated locations for XP_011236951.1

UniProtKB/TrEMBL

A0A087WSE3

Conserved Domains (8) summary

PHA03247
Location:1206 → 1610

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1490 → 1812

PHA03307; transcriptional regulator ICP4; Provisional

cd00063
Location:1946 → 2032

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14108
Location:868 → 1124

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

cd14111
Location:2222 → 2478

STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:82 → 138

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:755 → 844

I-set; Immunoglobulin I-set domain

cl11960
Location:243 → 328

Ig; Immunoglobulin domain
XM_030243476.2 → XP_030099336.1 striated muscle-specific serine/threonine-protein kinase isoform X19

Conserved Domains (4) summary

pfam16650
Location:82 → 138

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:1 → 81

I-set; Immunoglobulin I-set domain

cd00096
Location:9 → 17

Ig; Ig strand B [structural motif]

cd20975
Location:139 → 229

IgI_APEG-1_like; Immunoglobulin-like domain of human Aortic Preferentially Expressed Protein-1 (APEG-1) and similar proteins; a member of the I-set of IgSF domains
XM_036155175.1 → XP_036011068.1 striated muscle-specific serine/threonine-protein kinase isoform X19

Conserved Domains (4) summary

pfam16650
Location:82 → 138

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:1 → 81

I-set; Immunoglobulin I-set domain

cd00096
Location:9 → 17

Ig; Ig strand B [structural motif]

cd20975
Location:139 → 229

IgI_APEG-1_like; Immunoglobulin-like domain of human Aortic Preferentially Expressed Protein-1 (APEG-1) and similar proteins; a member of the I-set of IgSF domains
XM_006496403.5 → XP_006496466.1 striated muscle-specific serine/threonine-protein kinase isoform X10

See identical proteins and their annotated locations for XP_006496466.1

UniProtKB/TrEMBL

A0A087WSE3

Conserved Domains (7) summary

PHA03247
Location:1087 → 1491

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1371 → 1693

PHA03307; transcriptional regulator ICP4; Provisional

cd00063
Location:1827 → 1913

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14108
Location:749 → 1005

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

cd14111
Location:2103 → 2359

STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam07679
Location:636 → 725

I-set; Immunoglobulin I-set domain

cl11960
Location:124 → 209

Ig; Immunoglobulin domain
XM_006496404.5 → XP_006496467.1 striated muscle-specific serine/threonine-protein kinase isoform X10

See identical proteins and their annotated locations for XP_006496467.1

UniProtKB/TrEMBL

A0A087WSE3

Conserved Domains (7) summary

PHA03247
Location:1087 → 1491

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1371 → 1693

PHA03307; transcriptional regulator ICP4; Provisional

cd00063
Location:1827 → 1913

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14108
Location:749 → 1005

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

cd14111
Location:2103 → 2359

STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam07679
Location:636 → 725

I-set; Immunoglobulin I-set domain

cl11960
Location:124 → 209

Ig; Immunoglobulin domain
XM_036155197.1 → XP_036011090.1 striated muscle-specific serine/threonine-protein kinase isoform X20

UniProtKB/TrEMBL

A0A0R4J1J0

Related

ENSMUSP00000109217.2, ENSMUST00000113587.8

Conserved Domains (1) summary

cd20975
Location:20 → 110

IgI_APEG-1_like; Immunoglobulin-like domain of human Aortic Preferentially Expressed Protein-1 (APEG-1) and similar proteins; a member of the I-set of IgSF domains
XM_006496402.3 → XP_006496465.1 striated muscle-specific serine/threonine-protein kinase isoform X9

UniProtKB/TrEMBL

A0A087WSE3

Conserved Domains (8) summary

PHA03247
Location:1146 → 1550

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1430 → 1752

PHA03307; transcriptional regulator ICP4; Provisional

cd00063
Location:1886 → 1972

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14108
Location:808 → 1064

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

cd14111
Location:2162 → 2418

STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:24 → 78

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:695 → 784

I-set; Immunoglobulin I-set domain

cl11960
Location:183 → 268

Ig; Immunoglobulin domain
XM_030243348.2 → XP_030099208.1 striated muscle-specific serine/threonine-protein kinase isoform X12

Conserved Domains (5) summary

PHA03247
Location:237 → 641

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:521 → 843

PHA03307; transcriptional regulator ICP4; Provisional

cd00063
Location:977 → 1063

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:883 → 973

I-set; Immunoglobulin I-set domain

cl21453
Location:1253 → 1509

PKc_like; Protein Kinases, catalytic domain