U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Epha7 Eph receptor A7 [ Mus musculus (house mouse) ]

    Gene ID: 13841, updated on 2-Nov-2024

    Summary

    Official Symbol
    Epha7provided by MGI
    Official Full Name
    Eph receptor A7provided by MGI
    Primary source
    MGI:MGI:95276
    See related
    Ensembl:ENSMUSG00000028289 AllianceGenome:MGI:95276
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ebk; Ehk3; Mdk1; Cek11; Hek11
    Summary
    Enables chemorepellent activity; growth factor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including ephrin receptor signaling pathway; negative regulation of nervous system development; and regulation of protein phosphorylation. Acts upstream of or within nephric duct morphogenesis; nervous system development; and positive regulation of neuron apoptotic process. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; foot bone; genitourinary system; and sensory organ. Orthologous to human EPHA7 (EPH receptor A7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 6.7), CNS E11.5 (RPKM 6.2) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Epha7 in Genome Data Viewer
    Location:
    4 A4; 4 12.42 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (28811840..28969391)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (28813066..28967503)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene macrophage migration inhibitory factor, pseudogene 11 Neighboring gene STARR-seq mESC enhancer starr_09821 Neighboring gene predicted gene 11909 Neighboring gene STARR-seq mESC enhancer starr_09822 Neighboring gene STARR-seq mESC enhancer starr_09823 Neighboring gene STARR-seq mESC enhancer starr_09824 Neighboring gene STARR-seq mESC enhancer starr_09825 Neighboring gene STARR-seq mESC enhancer starr_09826 Neighboring gene STARR-seq mESC enhancer starr_09828 Neighboring gene predicted gene 11917 Neighboring gene predicted gene, 52716

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GPI-linked ephrin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables axon guidance receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables chemorepellent activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within branching morphogenesis of a nerve IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ephrin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of collateral sprouting IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within nephric duct morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynapse organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within retinal ganglion cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ephrin type-A receptor 7
    Names
    EPH homology kinase 3
    developmental kinase 1
    embryonic brain kinase
    NP_001116361.1
    NP_001277363.1
    NP_001407841.1
    NP_001407842.1
    NP_001407843.1
    NP_034271.3
    XP_006537670.1
    XP_036019542.1
    XP_036019543.1
    XP_036019544.1
    XP_036019545.1
    XP_036019547.1
    XP_036019548.1
    XP_036019549.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122889.2NP_001116361.1  ephrin type-A receptor 7 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001116361.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) has a different and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      BX000989
      Consensus CDS
      CCDS51132.1
      UniProtKB/TrEMBL
      Q8CC52
      Related
      ENSMUSP00000079735.5, ENSMUST00000080934.11
      Conserved Domains (4) summary
      cd10485
      Location:30206
      EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
      cd00063
      Location:443534
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:333427
      fn3; Fibronectin type III domain
      pfam07699
      Location:275312
      GCC2_GCC3; GCC2 and GCC3
    2. NM_001290434.2NP_001277363.1  ephrin type-A receptor 7 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001277363.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      BX000989
      Consensus CDS
      CCDS71353.1
      UniProtKB/TrEMBL
      A2BDQ4, Q8R381
      Related
      ENSMUSP00000103826.2, ENSMUST00000108191.2
      Conserved Domains (7) summary
      cd09548
      Location:915984
      SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
      smart00454
      Location:916983
      SAM; Sterile alpha motif
      cd10485
      Location:30206
      EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
      cd00063
      Location:443534
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:624890
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam07714
      Location:629886
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:565624
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    3. NM_001420912.1NP_001407841.1  ephrin type-A receptor 7 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      BX000989
    4. NM_001420913.1NP_001407842.1  ephrin type-A receptor 7 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      BX000989
    5. NM_001420914.1NP_001407843.1  ephrin type-A receptor 7 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      BX000989
    6. NM_010141.5NP_034271.3  ephrin type-A receptor 7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034271.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BX000989
      Consensus CDS
      CCDS18013.1
      UniProtKB/Swiss-Prot
      Q61505, Q61772, Q61773, Q61774, Q8BSU8
      UniProtKB/TrEMBL
      Q8R381
      Related
      ENSMUSP00000029964.6, ENSMUST00000029964.12
      Conserved Domains (7) summary
      cd09548
      Location:919988
      SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
      smart00454
      Location:920987
      SAM; Sterile alpha motif
      cd10485
      Location:30206
      EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
      cd00063
      Location:443534
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:628894
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam07714
      Location:633890
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:565628
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      28811840..28969391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537607.5XP_006537670.1  ephrin type-A receptor 7 isoform X9

      See identical proteins and their annotated locations for XP_006537670.1

      UniProtKB/Swiss-Prot
      Q61772
      Related
      ENSMUSP00000103829.3, ENSMUST00000108194.9
      Conserved Domains (3) summary
      cd10485
      Location:30206
      EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
      cd00063
      Location:443534
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07699
      Location:275312
      Ephrin_rec_like; Putative ephrin-receptor like
    2. XM_036163651.1XP_036019544.1  ephrin type-A receptor 7 isoform X3

      UniProtKB/TrEMBL
      Q8R381
      Conserved Domains (5) summary
      cd09548
      Location:838907
      SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
      cd00063
      Location:367458
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:547813
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam14575
      Location:484549
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1130
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    3. XM_036163652.1XP_036019545.1  ephrin type-A receptor 7 isoform X4

      UniProtKB/TrEMBL
      Q8R381
      Conserved Domains (5) summary
      cd09548
      Location:834903
      SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
      cd00063
      Location:367458
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:543809
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam14575
      Location:484545
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1130
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    4. XM_036163649.1XP_036019542.1  ephrin type-A receptor 7 isoform X1

      UniProtKB/TrEMBL
      Q8R381
      Conserved Domains (5) summary
      cd09548
      Location:843912
      SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
      cd00063
      Location:367458
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:552818
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam14575
      Location:489554
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1130
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    5. XM_036163650.1XP_036019543.1  ephrin type-A receptor 7 isoform X2

      UniProtKB/TrEMBL
      Q8R381
      Conserved Domains (5) summary
      cd09548
      Location:839908
      SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
      cd00063
      Location:367458
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:548814
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam14575
      Location:489550
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1130
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    6. XM_036163656.1XP_036019549.1  ephrin type-A receptor 7 isoform X7

      Conserved Domains (4) summary
      cd00063
      Location:367458
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:257351
      fn3; Fibronectin type III domain
      pfam07699
      Location:199236
      Ephrin_rec_like; Putative ephrin-receptor like
      cl02704
      Location:1130
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    7. XM_036163654.1XP_036019547.1  ephrin type-A receptor 7 isoform X1

      UniProtKB/TrEMBL
      Q8R381
      Conserved Domains (5) summary
      cd09548
      Location:843912
      SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
      cd00063
      Location:367458
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:552818
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam14575
      Location:489554
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1130
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    8. XM_036163655.1XP_036019548.1  ephrin type-A receptor 7 isoform X1

      UniProtKB/TrEMBL
      Q8R381
      Conserved Domains (5) summary
      cd09548
      Location:843912
      SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
      cd00063
      Location:367458
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:552818
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam14575
      Location:489554
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1130
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors

    RNA

    1. XR_004941807.1 RNA Sequence

    2. XR_004941806.1 RNA Sequence

    3. XR_004941808.1 RNA Sequence