Slc25a20 solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a20provided by MGI
Official Full Name: solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20provided by MGI
Primary source: MGI:MGI:1928738
See related: Ensembl:ENSMUSG00000032602 AllianceGenome:MGI:1928738
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAC; Cact; mCAC; 1110007P09Rik
Summary: Predicted to enable acyl carnitine transmembrane transporter activity. Acts upstream of or within in utero embryonic development. Located in mitochondrial inner membrane. Is expressed in cerebral cortex ventricular layer and cortical plate. Human ortholog(s) of this gene implicated in carnitine-acylcarnitine translocase deficiency. Orthologous to human SLC25A20 (solute carrier family 25 member 20). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in heart adult (RPKM 46.4), colon adult (RPKM 29.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.61 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (108539335..108561841)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (108662136..108684642)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the 50-flanking region of the Cact gene contains a consensus sequence for ERRalpha. This sequence binds ERRa both in vivo and in vitro and is required for the activation of Cact expression by the PGC-1/ERR axis
Title: PGC-1β regulates mouse carnitine-acylcarnitine translocase through estrogen-related receptor α.
Data show that the upregulation of CACT by PPARalpha and PPARdelta may increase the import of acylcarnitine into the mitochondrial matrix during fasting.
Title: Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE106540 (e-PCR)
- UniSTS:246308

RH126444 (e-PCR)
- UniSTS:163152

Slc25a20 (e-PCR), detects polymorphism
- UniSTS:547043

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acyl carnitine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables acyl carnitine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables acyl carnitine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in acyl carnitine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in carnitine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in carnitine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in carnitine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial carnitine/acylcarnitine carrier protein

NP_065266.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020520.5 → NP_065266.1 mitochondrial carnitine/acylcarnitine carrier protein

Status: VALIDATED

Source sequence(s)

CT571271

Consensus CDS

CCDS23535.1

UniProtKB/Swiss-Prot

Q3U801, Q9Z2Z6

UniProtKB/TrEMBL

Q7TPW6

Related

ENSMUSP00000035222.6, ENSMUST00000035222.6

Conserved Domains (1) summary

pfam00153
Location:106 → 198

Mito_carr; Mitochondrial carrier protein