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    FN1 fibronectin 1 [ Homo sapiens (human) ]

    Gene ID: 2335, updated on 3-Nov-2024

    Summary

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    Official Symbol
    FN1provided by HGNC
    Official Full Name
    fibronectin 1provided by HGNC
    Primary source
    HGNC:HGNC:3778
    See related
    Ensembl:ENSG00000115414 MIM:135600; AllianceGenome:HGNC:3778
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2; SMDCF
    Summary
    This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
    Expression
    Biased expression in placenta (RPKM 1097.5), liver (RPKM 415.5) and 7 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FN1 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (215360865..215436068, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (215845895..215921094, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (216225588..216300791, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124907975 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:216176486-216177136 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:216240057-216241256 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:216255920-216257119 Neighboring gene Sharpr-MPRA regulatory region 14446 Neighboring gene Sharpr-MPRA regulatory region 10603 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:216288045-216289244 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:216298103-216299302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12299 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12300 Neighboring gene uncharacterized LOC102724849 Neighboring gene FN1 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 5619 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:216392847-216394046 Neighboring gene uncharacterized LOC102724861 Neighboring gene Sharpr-MPRA regulatory region 4559 Neighboring gene NANOG hESC enhancer GRCh37_chr2:216491401-216491902 Neighboring gene long intergenic non-protein coding RNA 607

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Use of quantitative shotgun proteomics to identify fibronectin 1 as a potential plasma biomarker for clear cell carcinoma of the kidney. Yokomizo A, et al. Cancer Biomark, 2011-2012. PMID 22674303
    2. The expression of sialic fibronectin correlates with lymph node metastasis of thyroid malignant neoplasmas. Takeyama H, et al. Anticancer Res, 2011 Apr. PMID 21508391
    3. The A domain of fibronectin-binding protein B of Staphylococcus aureus contains a novel fibronectin binding site. Burke FM, et al. FEBS J, 2011 Jul. PMID 21569203
    4. Role of surface chemistry in protein remodeling at the cell-material interface. Llopis-Hernández V, et al. PLoS One, 2011 May 9. PMID 21573010, Free PMC Article
    5. Structural and functional analysis of the tandem β-zipper interaction of a Streptococcal protein with human fibronectin. Norris NC, et al. J Biol Chem, 2011 Nov 4. PMID 21840989, Free PMC Article

    See all (867) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The extracellular matrix protein fibronectin promotes metanephric kidney development.
      Title: The extracellular matrix protein fibronectin promotes metanephric kidney development.
    2. Rare genetic variation in fibronectin 1 (FN1) protects against APOEepsilon4 in Alzheimer's disease.
      Title: Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease.
    3. Superficial acral calcified chondroid mesenchymal neoplasm harboring an FN1::FGFR2 fusion and review of the literature.
      Title: Superficial acral calcified chondroid mesenchymal neoplasm harboring an FN1::FGFR2 fusion and review of the literature.
    4. Myocardin regulates fibronectin expression and secretion from human pleural mesothelial cells.
      Title: Myocardin regulates fibronectin expression and secretion from human pleural mesothelial cells.
    5. LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin.
      Title: LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin.
    6. Single-cell RNA sequencing reveals association of aberrant placental trophoblasts and FN1 reduction in late-onset fetal growth restriction.
      Title: Single-cell RNA sequencing reveals association of aberrant placental trophoblasts and FN1 reduction in late-onset fetal growth restriction.
    7. Circular RNA hsa_circ_0050386 suppresses non-small cell lung cancer progression via regulating the SRSF3/FN1 axis.
      Title: Circular RNA hsa_circ_0050386 suppresses non-small cell lung cancer progression via regulating the SRSF3/FN1 axis.
    8. Fibronectin sensitizes activation of contractility, YAP, and NF-kappaB in nucleus pulposus cells.
      Title: Fibronectin sensitizes activation of contractility, YAP, and NF-ÎşB in nucleus pulposus cells.
    9. FN1 and cancer-associated fibroblasts markers influence immune microenvironment in clear cell renal cell carcinoma.
      Title: FN1 and cancer-associated fibroblasts markers influence immune microenvironment in clear cell renal cell carcinoma.
    10. FN1 and TGFBI are key biomarkers of macrophage immune injury in diabetic kidney disease.
      Title: FN1 and TGFBI are key biomarkers of macrophage immune injury in diabetic kidney disease.
    Submit: New GeneRIF Correction See all GeneRIFs (547)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 induces phosphorylation of fibronectin and enhances a physical association between fibronectin and Robo4 in human lymphatic endothelial cells PubMed
    env Fibronectin, which is present in submandibular saliva, binds to HIV-1 gp120/160 and enhances the interaction of C1q with gp120/160 PubMed
    env HIV-1 gp120 binds to fibronectin (FN) present on the surface of platelets; the specificity of this binding is confirmed by the inhibition obtained by pretreating platelets with anti-FN antibodies PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 and gp120 specifically recognize the C-terminal heparin-binding domain of fibronectin (Fn) and this binding inhibits the interaction of gp160/gp120 with soluble CD4 PubMed
    Envelope transmembrane glycoprotein gp41 env Fibronectin (FN) binds to HIV-1 glycoproteins, including gp41 and gp120; preincubation with antibodies against FN abolishes this binding PubMed
    Nef nef Exogenous HIV-1 Nef upregulates fibronectin (FN) expression in MT4 and H9 T-cell lines PubMed
    Tat tat HIV-1 Tat competes with fibronectin for binding to integrins PubMed
    tat Fibronectin modulates the effects of HIV-1 Tat on endothelial cells and murine Kaposi's sarcoma-like cells PubMed
    tat HIV-1 Tat upregulates fibronectin expression in salivary gland cell lines, thymic epithelial cells, and glioblastoma cells PubMed
    retropepsin gag-pol The cell-associated protein fibronectin (A-chain) is specifically cleaved in vitro by HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686H0342, DKFZp686I1370, DKFZp686F10164, DKFZp686O13149

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables collagen binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables extracellular matrix structural constituent HDA PubMed 
    enables extracellular matrix structural constituent ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables heparin binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables integrin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables peptidase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables proteoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables receptor ligand activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acute-phase response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological process involved in interaction with symbiont IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium-independent cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-substrate junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endodermal cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of monocyte activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neural crest cell migration involved in autonomic nervous system development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptide cross-linking IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to muscle activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to wounding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in blood microparticle HDA PubMed 
    colocalizes_with collagen-containing extracellular matrix HDA PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with collagen-containing extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region HDA PubMed 
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of fibrinogen complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of fibrinogen complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    fibronectin
    Names
    cold-insoluble globulin
    epididymis secretory sperm binding protein
    lnc-ABCA12-8
    migration-stimulating factor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012196.2 RefSeqGene

      Range
      5000..80203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306129.2 → NP_001293058.2  fibronectin isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS77526.1
      UniProtKB/TrEMBL
      B7ZLE5
      Related
      ENSP00000323534.6, ENST00000323926.10
      Conserved Domains (6) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186 → 230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2354 → 2393
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1995 → 2075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1540 → 1621
      fn3; Fibronectin type III domain

    2. NM_001306130.2 → NP_001293059.2  fibronectin isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS77525.1
      UniProtKB/TrEMBL
      A0A384MR03
      Related
      ENSP00000399538.2, ENST00000432072.6
      Conserved Domains (6) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186 → 230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2175 → 2214
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1905 → 1985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1540 → 1621
      fn3; Fibronectin type III domain

    3. NM_001306131.2 → NP_001293060.2  fibronectin isoform 10 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS77523.1
      UniProtKB/TrEMBL
      B7ZLE5
      Related
      ENSP00000415018.1, ENST00000443816.5
      Conserved Domains (6) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186 → 230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2173 → 2212
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1814 → 1894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1449 → 1530
      fn3; Fibronectin type III domain

    4. NM_001306132.2 → NP_001293061.2  fibronectin isoform 11 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS77522.1
      UniProtKB/TrEMBL
      B7ZLE5
      Related
      ENSP00000394423.1, ENST00000421182.5
      Conserved Domains (6) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186 → 230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2148 → 2187
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1814 → 1894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1449 → 1530
      fn3; Fibronectin type III domain

    5. NM_001365517.2 → NP_001352446.1  fibronectin isoform 12 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      UniProtKB/TrEMBL
      B7ZLE5
      Conserved Domains (5) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186 → 230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2295 → 2334
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1540 → 1619
      fn3; Fibronectin type III domain

    6. NM_001365518.2 → NP_001352447.1  fibronectin isoform 13 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS92940.1
      UniProtKB/TrEMBL
      B7ZLE5
      Related
      ENSP00000352696.1, ENST00000359671.5
      Conserved Domains (5) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186 → 230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2294 → 2333
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1449 → 1528
      fn3; Fibronectin type III domain

    7. NM_001365519.2 → NP_001352448.1  fibronectin isoform 14 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      UniProtKB/TrEMBL
      B7ZLE5
      Conserved Domains (5) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186 → 230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2270 → 2309
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1540 → 1619
      fn3; Fibronectin type III domain

    8. NM_001365520.2 → NP_001352449.1  fibronectin isoform 15 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      UniProtKB/TrEMBL
      B7ZLE5
      Conserved Domains (5) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186 → 230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2269 → 2308
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1449 → 1528
      fn3; Fibronectin type III domain

    9. NM_001365521.2 → NP_001352450.1  fibronectin isoform 16 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      UniProtKB/TrEMBL
      B7ZLE5
      Conserved Domains (5) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186 → 230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2264 → 2303
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1540 → 1619
      fn3; Fibronectin type III domain

    10. NM_001365522.2 → NP_001352451.1  fibronectin isoform 17 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      UniProtKB/TrEMBL
      B7ZLE5
      Conserved Domains (5) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186 → 230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2239 → 2278
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1540 → 1619
      fn3; Fibronectin type III domain

    11. NM_001365523.2 → NP_001352452.1  fibronectin isoform 18 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      UniProtKB/TrEMBL
      B7ZLE5
      Conserved Domains (5) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186 → 230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2179 → 2218
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1449 → 1528
      fn3; Fibronectin type III domain

    12. NM_001365524.2 → NP_001352453.1  fibronectin isoform 19 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      UniProtKB/TrEMBL
      A0A384MR03
      Conserved Domains (5) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186 → 230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2174 → 2213
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1449 → 1528
      fn3; Fibronectin type III domain

    13. NM_002026.4 → NP_002017.2  fibronectin isoform 3 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS2399.1
      UniProtKB/TrEMBL
      B7ZLE5
      Related
      ENSP00000338200.4, ENST00000336916.8

    14. NM_054034.3 → NP_473375.2  fibronectin isoform 7 preproprotein

      See identical proteins and their annotated locations for NP_473375.2

      Status: REVIEWED

      Source sequence(s)
      AC012462
      Consensus CDS
      CCDS46512.1
      UniProtKB/Swiss-Prot
      P02751
      Related
      ENSP00000398907.1, ENST00000426059.1
      Conserved Domains (4) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186 → 230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:52 → 89
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain

    15. NM_212474.3 → NP_997639.2  fibronectin isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS2400.1
      UniProtKB/TrEMBL
      A0A384MR03
      Related
      ENSP00000350534.4, ENST00000357867.8

    16. NM_212476.3 → NP_997641.2  fibronectin isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS42813.1
      UniProtKB/TrEMBL
      B7ZLE5
      Related
      ENSP00000348285.4, ENST00000356005.8

    17. NM_212478.3 → NP_997643.2  fibronectin isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS46510.1
      UniProtKB/TrEMBL
      B7ZLE5
      Related
      ENSP00000410422.1, ENST00000446046.5
      Conserved Domains (5) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186 → 230
      FN1; Fibronectin type 1 domain
      smart00060
      Location:1268 → 1347
      FN3; Fibronectin type 3 domain
      cd00061
      Location:2238 → 2277
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1904 → 1984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    18. NM_212482.4 → NP_997647.2  fibronectin isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS42814.1
      UniProtKB/Swiss-Prot
      B7ZLF0, E9PE77, E9PG29, O95609, O95610, P02751, Q14312, Q14325, Q14326, Q17RV7, Q53S27, Q564H7, Q585T2, Q59EH1, Q60FE4, Q68DP8, Q68DP9, Q68DT4, Q6LDP6, Q6MZS0, Q6MZU5, Q6N025, Q6N0A6, Q7Z391, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2
      UniProtKB/TrEMBL
      B7ZLE5
      Related
      ENSP00000346839.4, ENST00000354785.11
      Conserved Domains (6) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186 → 230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2385 → 2424
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1995 → 2075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1540 → 1621
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      215360865..215436068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      215845895..215921094 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_212475.1: Suppressed sequence

      Description
      NM_212475.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02751.5 GenPept UniProtKB/Swiss-Prot:P02751

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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