RBM33 RNA binding motif protein 33 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RBM33provided by HGNC
Official Full Name: RNA binding motif protein 33provided by HGNC
Primary source: HGNC:HGNC:27223
See related: Ensembl:ENSG00000184863 MIM:620833; AllianceGenome:HGNC:27223
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PRR8
Summary: Enables N6-methyladenosine-containing RNA reader activity and lncRNA binding activity. Involved in RNA export from nucleus and regulation of mRNA stability. Located in cytoplasm. Is active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bone marrow (RPKM 11.9), skin (RPKM 7.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q36.3

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (155644661..155781480)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (156825729..156962514)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (155437355..155574174)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Biogenesis of circRBM33 mediated by N6-methyladenosine and its function in abdominal aortic aneurysm.
Title: Biogenesis of circRBM33 mediated by N6-methyladenosine and its function in abdominal aortic aneurysm.
RBM33 is a unique m[6]A RNA-binding protein that regulates ALKBH5 demethylase activity and substrate selectivity.
Title: RBM33 is a unique m(6)A RNA-binding protein that regulates ALKBH5 demethylase activity and substrate selectivity.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7S2392 (e-PCR)
- UniSTS:154167

SGC34464 (e-PCR)
- UniSTS:1855

RH45459 (e-PCR)
- UniSTS:31047

ATC-P7576 (e-PCR)
- UniSTS:32840

RH11021 (e-PCR)
- UniSTS:49228

D7S550 (e-PCR)
- UniSTS:67923

RH48753 (e-PCR)
- UniSTS:80215

mEgCIR2224 (e-PCR), detects polymorphism
- UniSTS:544856

D7S2307 (e-PCR)
- UniSTS:1124

G09465 (e-PCR)
- UniSTS:61034

D7S3034 (e-PCR)
- UniSTS:254334

SHGC-110879 (e-PCR)
- UniSTS:168065

WI-18043 (e-PCR)
- UniSTS:46468

NoName (e-PCR)
- UniSTS:485766

SHGC-53753 (e-PCR)
- UniSTS:48282

RH16482 (e-PCR)
- UniSTS:23716

D7S550 (e-PCR)
- UniSTS:75178

G29161 (e-PCR)
- UniSTS:75434

D7S392 (e-PCR)
- UniSTS:27069

RH18251 (e-PCR)
- UniSTS:63448

STS-T84461 (e-PCR)
- UniSTS:67298

RH45482 (e-PCR)
- UniSTS:6652

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables N6-methyladenosine-containing RNA reader activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	HDA more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables lncRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA stability	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RNA-binding protein 33

Names: hypothetical protein MGC20460; proline rich 8; proline-rich protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053043.3 → NP_444271.2 RNA-binding protein 33

See identical proteins and their annotated locations for NP_444271.2

Status: VALIDATED

Source sequence(s)

AC078834, AL137724, AL832196, BC011923, BP373239, CN402759, DA459140, DA504982, DA947894

Consensus CDS

CCDS5941.2

UniProtKB/Swiss-Prot

A4D244, B5MC24, Q52LF5, Q75LN9, Q75ML5, Q96EV2, Q9NSV0

Related

ENSP00000384160.3, ENST00000401878.8

Conserved Domains (1) summary

cd00590
Location:1100 → 1165

RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

155644661..155781480

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

156825729..156962514

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001008408.3: Suppressed sequence

Description

NM_001008408.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.