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    Cd55 CD55 molecule, decay accelerating factor for complement [ Mus musculus (house mouse) ]

    Gene ID: 13136, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cd55provided by MGI
    Official Full Name
    CD55 molecule, decay accelerating factor for complementprovided by MGI
    Primary source
    MGI:MGI:104850
    See related
    Ensembl:ENSMUSG00000026399 AllianceGenome:MGI:104850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Daf; Daf1; Daf-GPI; GPI-DAF
    Summary
    This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. The encoded preproprotein undergoes post-translational processing to generate a mature polypeptide anchored to the plasma membrane via a glycosylphosphatidylinositol moiety. Erythrocytes from mice deficient in the encoded protein exhibit impaired regulation of complement activation resulting in enhanced complement deposition. Mice lacking the encoded protein exhibit enhanced susceptibility to experimentally induced myasthenia gravis. This gene is located adjacent to a closely related gene on chromosome 1. [provided by RefSeq, Nov 2015]
    Expression
    Broad expression in bladder adult (RPKM 9.5), testis adult (RPKM 5.4) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cd55 in Genome Data Viewer
    Location:
    1 E4; 1 56.89 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130357526..130390513, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130429798..130465009, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02193 Neighboring gene predicted gene, 41951 Neighboring gene STARR-seq mESC enhancer starr_02194 Neighboring gene CD55 molecule, decay accelerating factor for complement B Neighboring gene CD55 molecule, opposite strand sequence Neighboring gene STARR-positive B cell enhancer ABC_E9183 Neighboring gene STARR-positive B cell enhancer ABC_E7745 Neighboring gene STARR-seq mESC enhancer starr_02195 Neighboring gene predicted gene 16083 Neighboring gene STARR-positive B cell enhancer ABC_E11084 Neighboring gene STARR-seq mESC enhancer starr_02198 Neighboring gene STARR-positive B cell enhancer mm9_chr1:132472703-132473004 Neighboring gene zona pellucida 3 receptor Neighboring gene predicted gene, 23623

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Decay-accelerating factor deficiency increases susceptibility to dextran sulfate sodium-induced colitis: role for complement in inflammatory bowel disease. Lin F, et al. J Immunol, 2004 Mar 15. PMID 15004190
    2. Augmenting DAF levels in vivo ameliorates experimental autoimmune encephalomyelitis. Li Q, et al. Mol Immunol, 2009 Sep. PMID 19660813, Free PMC Article
    3. Tissue distribution of products of the mouse decay-accelerating factor (DAF) genes. Exploitation of a Daf1 knock-out mouse and site-specific monoclonal antibodies. Lin F, et al. Immunology, 2001 Oct. PMID 11683962, Free PMC Article
    4. CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis. Karpus ON, et al. Arthritis Res Ther, 2015 Jan 17. PMID 25596646, Free PMC Article
    5. A preliminary study on the role of the complement regulatory protein, cluster of differentiation 55, in mice with diabetic neuropathic pain. Nie F, et al. Mol Med Rep, 2015 Mar. PMID 25377281

    See all (120) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exercise training upregulates CD55 to suppress complement-mediated synaptic phagocytosis in Parkinson's disease.
      Title: Exercise training upregulates CD55 to suppress complement-mediated synaptic phagocytosis in Parkinson's disease.
    2. Critical Role of CD55 in Controlling Wound Healing.
      Title: Critical Role of CD55 in Controlling Wound Healing.
    3. Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis.
      Title: Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis.
    4. Mitigating placental injuries through up-regulating DAF in experimental APS mice: new mechanism of progesterone.
      Title: Mitigating placental injuries through up-regulating DAF in experimental APS mice: new mechanism of progesterone.
    5. DAF is required for the properties of CD103(+) DCs and their naive CD4(+) cell partners that together program tolerance.
      Title: CD55 Is Essential for CD103(+) Dendritic Cell Tolerogenic Responses that Protect against Autoimmunity.
    6. CD133-CD55- common progenitors are the main source of CXCL12 and Kitl producing cells in the developing marrow.
      Title: Identification of a CD133-CD55- population functions as a fetal common skeletal progenitor.
    7. regulates self-renewal and cisplatin resistance in endometrioid tumors
      Title: CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors.
    8. Results show that definitive endoderm (DE) expressing Daf1 are slowly proliferating and adhesive cells suggesting that Daf1 is a marker of late stage DE.
      Title: Late stage definitive endodermal differentiation can be defined by Daf1 expression.
    9. these data show a key role for HIF-1alpha in regulating the expression of CD55 on airway epithelium.
      Title: Hypoxia-Inducible Factor-1α Regulates CD55 in Airway Epithelium.
    10. CD55 is produced by the synovium and deposited on local collagen fiber meshwork, where it protects against immune complex-mediated arthritis.
      Title: CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis.
    Submit: New GeneRIF Correction See all GeneRIFs (50)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • AC111067.4

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of complement activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of complement activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of CD4-positive, alpha-beta T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of complement activation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of complement activation, classical pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of complement-dependent cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    complement decay-accelerating factor, GPI-anchored
    Names
    CD55 antigen
    Cromer blood group
    GPI anchor addition signal
    complement-glycosylphosphatidylinositol
    decay accelerating factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001404959.1 → NP_001391888.1  complement decay-accelerating factor, GPI-anchored isoform 2 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC111067

    2. NM_001404960.2 → NP_001391889.1  complement decay-accelerating factor, GPI-anchored isoform 3 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC111067

    3. NM_001420093.1 → NP_001407022.1  complement decay-accelerating factor, GPI-anchored isoform 4 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC111067

    4. NM_010016.5 → NP_034146.2  complement decay-accelerating factor, GPI-anchored isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_034146.2

      Status: REVIEWED

      Source sequence(s)
      AC111067
      Consensus CDS
      CCDS15256.1
      UniProtKB/Swiss-Prot
      P97732, Q3TU32, Q4FJS4, Q61397, Q61475, Q76N72, Q921P0, Q9R1C1
      Related
      ENSMUSP00000027650.7, ENSMUST00000027650.13
      Conserved Domains (2) summary
      cd00033
      Location:225 → 285
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:98 → 158
      Sushi; Sushi repeat (SCR repeat)

    RNA

    1. NR_175895.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC111067

    2. NR_175896.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC111067

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      130357526..130390513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246237.2 → XP_030102097.1  complement decay-accelerating factor, GPI-anchored isoform X2

      Conserved Domains (3) summary
      pfam00802
      Location:285 → 361
      Glycoprotein_G; Pneumovirus attachment glycoprotein G
      cd00033
      Location:36 → 95
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:98 → 292
      PHA02927; secreted complement-binding protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61475.2 GenPept UniProtKB/Swiss-Prot:Q61475

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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