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    Lyzl4 lysozyme-like 4 [ Mus musculus (house mouse) ]

    Gene ID: 69032, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lyzl4provided by MGI
    Official Full Name
    lysozyme-like 4provided by MGI
    Primary source
    MGI:MGI:1916282
    See related
    Ensembl:ENSMUSG00000032530 AllianceGenome:MGI:1916282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lyc4; Lyza; 1810009N24Rik
    Summary
    Predicted to enable lysozyme activity. Involved in fertilization. Located in acrosomal vesicle; extracellular space; and sperm flagellum. Is expressed in craniocervical region bone; ganglia; medulla oblongata basal plate mantle layer; and stomach. Orthologous to human LYZL4 (lysozyme like 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 38.8) See more
    Orthologs
    human all
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    Genomic context

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    See Lyzl4 in Genome Data Viewer
    Location:
    9 F4; 9 72.45 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121406907..121471187, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (121577841..121642121, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38661 Neighboring gene cholecystokinin Neighboring gene predicted gene, 47095 Neighboring gene lysozyme-like 4, opposite strand Neighboring gene STARR-seq mESC enhancer starr_25538 Neighboring gene vasoactive intestinal peptide receptor 1 Neighboring gene STARR-positive B cell enhancer ABC_E10592 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:121591571-121591680 Neighboring gene STARR-positive B cell enhancer mm9_chr9:121606658-121606959 Neighboring gene SEC22 homolog C, vesicle trafficking protein Neighboring gene STARR-positive B cell enhancer ABC_E11426

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lyzl4, a novel mouse sperm-related protein, is involved in fertilization. Sun R, et al. Acta Biochim Biophys Sin (Shanghai), 2011 May. PMID 21444326
    2. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lysozyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lysozyme-like protein 4
    Names
    lysozyme a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357346.2 → NP_001344275.2  lysozyme-like protein 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC131660, AC159810
      UniProtKB/Swiss-Prot
      Q9D925
      UniProtKB/TrEMBL
      A0A1L1SV59, Q78ID0
      Related
      ENSMUSP00000113034.2, ENSMUST00000120918.8
      Conserved Domains (1) summary
      cd16897
      Location:21 → 143
      LYZ_C; C-type lysozyme

    2. NM_001382835.1 → NP_001369764.1  lysozyme-like protein 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC131660
      UniProtKB/Swiss-Prot
      Q9D925
      UniProtKB/TrEMBL
      A0A1L1SV59, Q78ID0
      Related
      ENSMUSP00000151031.2, ENSMUST00000213757.2
      Conserved Domains (1) summary
      cd16897
      Location:21 → 143
      LYZ_C; C-type lysozyme

    3. NM_026915.4 → NP_081191.1  lysozyme-like protein 4 precursor

      See identical proteins and their annotated locations for NP_081191.1

      Status: VALIDATED

      Source sequence(s)
      AC131660, AC159810
      Consensus CDS
      CCDS23632.1
      UniProtKB/Swiss-Prot
      Q9D925
      UniProtKB/TrEMBL
      A0A1L1SV59, Q78ID0
      Related
      ENSMUSP00000076887.4, ENSMUST00000077706.10
      Conserved Domains (1) summary
      cd16897
      Location:21 → 143
      LYZ_C; C-type lysozyme

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      121406907..121471187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512248.2 → XP_006512311.1  lysozyme-like protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006512311.1

      UniProtKB/Swiss-Prot
      Q9D925
      UniProtKB/TrEMBL
      A0A1L1SV59, Q78ID0
      Conserved Domains (1) summary
      cd16897
      Location:21 → 143
      LYZ_C; C-type lysozyme
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D925.3 GenPept UniProtKB/Swiss-Prot:Q9D925

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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