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    Efcab14 EF-hand calcium binding domain 14 [ Mus musculus (house mouse) ]

    Gene ID: 230648, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Efcab14provided by MGI
    Official Full Name
    EF-hand calcium binding domain 14provided by MGI
    Primary source
    MGI:MGI:2442397
    See related
    Ensembl:ENSMUSG00000034210 AllianceGenome:MGI:2442397
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4732418C07Rik
    Summary
    Predicted to enable metal ion binding activity. Is expressed in several structures, including genitourinary system; gut gland; liver and biliary system; nervous system; and retina nuclear layer. Orthologous to human EFCAB14 (EF-hand calcium binding domain 14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 10.8), adrenal adult (RPKM 10.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Efcab14 in Genome Data Viewer
    Location:
    4 D1; 4 53.06 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115594914..115634590)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115737716..115777393)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 4, subfamily b, polypeptide 1 Neighboring gene eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) pseudogene Neighboring gene testis expressed 38 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1 Neighboring gene STARR-seq mESC enhancer starr_11125 Neighboring gene MOB kinase activator 3C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability. Koochaki SHJ, et al. J Biol Chem, 2022 Oct. PMID 36108743, Free PMC Article
    2. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0494

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    EF-hand calcium-binding domain-containing protein 14

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368627.1 → NP_001355556.1  EF-hand calcium-binding domain-containing protein 14 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK028618, AL626806
      Consensus CDS
      CCDS89810.1
      UniProtKB/Swiss-Prot
      A2A8U1, Q3TQN6, Q8BGQ6, Q8BJV7, Q8C0R1
      UniProtKB/TrEMBL
      Q3V1D2
      Related
      ENSMUSP00000102135.3, ENSMUST00000106525.9
      Conserved Domains (1) summary
      COG1196
      Location:97 → 331
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_172698.2 → NP_766286.2  EF-hand calcium-binding domain-containing protein 14 isoform 1

      See identical proteins and their annotated locations for NP_766286.2

      Status: VALIDATED

      Source sequence(s)
      BC059213
      Consensus CDS
      CCDS18494.1
      UniProtKB/TrEMBL
      Q3V1D2, Q6PCQ6
      Related
      ENSMUSP00000074025.7, ENSMUST00000074425.13
      Conserved Domains (1) summary
      COG1196
      Location:97 → 333
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      115594914..115634590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164033.1 → XP_036019926.1  EF-hand calcium-binding domain-containing protein 14 isoform X3

      UniProtKB/TrEMBL
      Q3V1D2
      Related
      ENSMUSP00000102134.4, ENSMUST00000106524.4

    2. XM_036164034.1 → XP_036019927.1  EF-hand calcium-binding domain-containing protein 14 isoform X4

      UniProtKB/TrEMBL
      Q3V1D2
      Conserved Domains (1) summary
      TIGR04523
      Location:97 → 376
      Mplasa_alph_rch; helix-rich Mycoplasma protein

    3. XM_036164032.1 → XP_036019925.1  EF-hand calcium-binding domain-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      Q3V1D2
      Conserved Domains (1) summary
      TIGR04523
      Location:97 → 376
      Mplasa_alph_rch; helix-rich Mycoplasma protein

    4. XM_006503006.5 → XP_006503069.1  EF-hand calcium-binding domain-containing protein 14 isoform X2

      See identical proteins and their annotated locations for XP_006503069.1

      UniProtKB/Swiss-Prot
      A2A8U1, Q3TQN6, Q8BGQ6, Q8BJV7, Q8C0R1
      UniProtKB/TrEMBL
      Q3V1D2
      Related
      ENSMUSP00000102132.3, ENSMUST00000106522.9
      Conserved Domains (1) summary
      COG1196
      Location:97 → 331
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGQ6.1 GenPept UniProtKB/Swiss-Prot:Q8BGQ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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