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    Nemf nuclear export mediator factor [ Mus musculus (house mouse) ]

    Gene ID: 66244, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nemfprovided by MGI
    Official Full Name
    nuclear export mediator factorprovided by MGI
    Primary source
    MGI:MGI:1918305
    See related
    Ensembl:ENSMUSG00000020982 AllianceGenome:MGI:1918305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sdccag1; 1500011I12Rik; 4933405E14Rik
    Summary
    Predicted to enable alpha-aminoacyl-tRNA binding activity; ribosomal large subunit binding activity; and tRNA binding activity. Involved in CAT tailing. Predicted to be located in cytosol. Predicted to be part of RQC complex. Predicted to be active in cytosolic ribosome. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and hemolymphoid system gland. Used to study neuromuscular disease and neuropathy. Orthologous to human NEMF (nuclear export mediator factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 12.6), CNS E14 (RPKM 9.0) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nemf in Genome Data Viewer
    Location:
    12 C2; 12 28.78 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69358315..69403975, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69311541..69357201, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene polymerase (DNA directed), epsilon 2 (p59 subunit) Neighboring gene STARR-positive B cell enhancer ABC_E10753 Neighboring gene kelch domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_32363 Neighboring gene kelch domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_32364 Neighboring gene STARR-positive B cell enhancer ABC_E10754 Neighboring gene STARR-positive B cell enhancer ABC_E7139 Neighboring gene STARR-positive B cell enhancer ABC_E600 Neighboring gene STARR-seq mESC enhancer starr_32366 Neighboring gene 7S RNA 2 Neighboring gene ribosomal protein S3A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal Morphogenesis and Cell Survival. Udagawa T, et al. Cell Rep, 2021 Jan 5. PMID 33406423
    2. NEMF mutations that impair ribosome-associated quality control are associated with neuromuscular disease. Martin PB, et al. Nat Commun, 2020 Sep 15. PMID 32934225, Free PMC Article
    3. Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing. Thrun A, et al. Mol Cell, 2021 May 20. PMID 33909987, Free PMC Article
    4. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
    5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NEMF mutations that impair ribosome-associated quality control are associated with neuromuscular disease.
      Title: NEMF mutations that impair ribosome-associated quality control are associated with neuromuscular disease.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-aminoacyl-tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-aminoacyl-tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal large subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal large subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal large subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in CAT tailing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in CAT tailing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear export IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear export ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in rescue of stalled ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RQC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RQC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RQC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosolic ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosome quality control complex subunit NEMF
    Names
    nuclear export mediator factor Nemf
    serologically defined colon cancer antigen 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025441.3 → NP_079717.2  ribosome quality control complex subunit NEMF

      See identical proteins and their annotated locations for NP_079717.2

      Status: VALIDATED

      Source sequence(s)
      AK039497, AK149005, BC039647, BY241581, CB524482
      Consensus CDS
      CCDS25951.1
      UniProtKB/Swiss-Prot
      Q3TAS9, Q3UF46, Q66JX6, Q8C9R6, Q8CA65, Q8CCP0, Q8JZT9, Q8R072, Q9CW30, Q9CYB8, Q9D4A9
      Related
      ENSMUSP00000021368.9, ENSMUST00000021368.10
      Conserved Domains (4) summary
      COG1293
      Location:1 → 642
      YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]
      pfam05670
      Location:530 → 604
      DUF814; Domain of unknown function (DUF814)
      pfam11923
      Location:959 → 1055
      DUF3441; Domain of unknown function (DUF3441)
      cl22451
      Location:656 → 762
      ASF1_hist_chap; ASF1 like histone chaperone

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      69358315..69403975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246848.2 → XP_030102708.1  ribosome quality control complex subunit NEMF isoform X2

      Conserved Domains (2) summary
      pfam05670
      Location:175 → 285
      DUF814; Domain of unknown function (DUF814)
      pfam11923
      Location:611 → 702
      DUF3441; Domain of unknown function (DUF3441)

    2. XM_011244157.4 → XP_011242459.1  ribosome quality control complex subunit NEMF isoform X1

      Conserved Domains (1) summary
      COG1293
      Location:1 → 642
      YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181665.1: Suppressed sequence

      Description
      NM_181665.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CCP0.2 GenPept UniProtKB/Swiss-Prot:Q8CCP0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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