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    Atf7ip2 activating transcription factor 7 interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 75329, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Atf7ip2provided by MGI
    Official Full Name
    activating transcription factor 7 interacting protein 2provided by MGI
    Primary source
    MGI:MGI:1922579
    See related
    Ensembl:ENSMUSG00000039200 AllianceGenome:MGI:1922579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PSM2; Get-1; 4930558K11Rik
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be involved in positive regulation of DNA methylation-dependent heterochromatin formation and regulation of DNA-templated transcription. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; gut; heart; liver; and lung. Orthologous to human ATF7IP2 (activating transcription factor 7 interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 1.2), placenta adult (RPKM 0.6) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atf7ip2 in Genome Data Viewer
    Location:
    16 A1; 16 5.5 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10010513..10068595)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (10192649..10250731)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_40070 Neighboring gene STARR-seq mESC enhancer starr_40071 Neighboring gene STARR-seq mESC enhancer starr_40072 Neighboring gene STARR-seq mESC enhancer starr_40073 Neighboring gene ribosomal protein L39-like Neighboring gene STARR-seq mESC enhancer starr_40074 Neighboring gene STARR-seq mESC enhancer starr_40076 Neighboring gene predicted gene, 24667 Neighboring gene epithelial membrane protein 2 Neighboring gene STARR-seq mESC enhancer starr_40077 Neighboring gene predicted gene 1600

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ATF7IP2, a meiosis-specific partner of SETDB1, is required for proper chromosome remodeling and crossover formation during spermatogenesis. Shao Q, et al. Cell Rep, 2023 Aug 29. PMID 37542719
    2. PSM2, a novel protein similar to MCAF2, is involved in the mouse embryonic and adult male gonad development. Cai H, et al. Mol Biol Rep, 2006 Sep. PMID 16850184
    3. Global gene expression analysis in fetal mouse ovaries with and without meiosis and comparison of selected genes with meiosis in the testis. Olesen C, et al. Cell Tissue Res, 2007 Apr. PMID 17431699
    4. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6783

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA methylation-dependent heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    activating transcription factor 7-interacting protein 2
    Names
    MBD1-containing chromatin-associated factor 2
    protein similar to MCAF2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029253.1 → NP_083529.1  activating transcription factor 7-interacting protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses different segments for its 3' coding region and 3' UTR, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AK016180, AK145634
      Consensus CDS
      CCDS49759.1
      UniProtKB/Swiss-Prot
      Q3UL97
      Related
      ENSMUSP00000113480.2, ENSMUST00000119023.8
      Conserved Domains (1) summary
      pfam16788
      Location:59 → 260
      ATF7IP_BD; ATF-interacting protein binding domain

    2. NM_153123.2 → NP_694763.2  activating transcription factor 7-interacting protein 2 isoform 1

      See identical proteins and their annotated locations for NP_694763.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC154311, AK145634, BY715784
      Consensus CDS
      CCDS49758.1
      UniProtKB/Swiss-Prot
      Q3UL97, Q3UT16, Q4VIF3, Q8BPC5, Q9D4T8
      Related
      ENSMUSP00000036731.8, ENSMUST00000044005.14
      Conserved Domains (2) summary
      pfam16788
      Location:59 → 260
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:345 → 443
      fn3_4; Fibronectin-III type domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      10010513..10068595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246039.3 → XP_011244341.1  activating transcription factor 7-interacting protein 2 isoform X2

      Conserved Domains (1) summary
      pfam16788
      Location:59 → 264
      ATF7IP_BD; ATF-interacting protein binding domain

    2. XM_006522684.4 → XP_006522747.1  activating transcription factor 7-interacting protein 2 isoform X3

      Conserved Domains (1) summary
      pfam16788
      Location:59 → 264
      ATF7IP_BD; ATF-interacting protein binding domain

    3. XM_006522682.3 → XP_006522745.1  activating transcription factor 7-interacting protein 2 isoform X1

      Conserved Domains (2) summary
      pfam16788
      Location:59 → 223
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:304 → 402
      fn3_4; Fibronectin-III type domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UL97.1 GenPept UniProtKB/Swiss-Prot:Q3UL97

    Gene LinkOut

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