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    Golga5 golgin A5 [ Mus musculus (house mouse) ]

    Gene ID: 27277, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Golga5provided by MGI
    Official Full Name
    golgin A5provided by MGI
    Primary source
    MGI:MGI:1351475
    See related
    Ensembl:ENSMUSG00000021192 AllianceGenome:MGI:1351475
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ret-II
    Summary
    Predicted to enable protein homodimerization activity; protein-macromolecule adaptor activity; and small GTPase binding activity. Predicted to be involved in Golgi organization and retrograde transport, vesicle recycling within Golgi. Located in Golgi membrane. Is expressed in several structures, including alimentary system; central nervous system; limb bud; liver; and spleen. Orthologous to human GOLGA5 (golgin A5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 11.9), testis adult (RPKM 11.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Golga5 in Genome Data Viewer
    Location:
    12 E; 12 51.51 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (102435372..102464274)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (102469109..102498015)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33096 Neighboring gene legumain Neighboring gene STARR-positive B cell enhancer ABC_E1862 Neighboring gene STARR-positive B cell enhancer ABC_E7170 Neighboring gene STARR-positive B cell enhancer ABC_E3066 Neighboring gene STARR-positive B cell enhancer ABC_E9150 Neighboring gene STARR-positive B cell enhancer ABC_E7171 Neighboring gene predicted gene, 30198 Neighboring gene STARR-seq mESC enhancer starr_33098 Neighboring gene STARR-seq mESC enhancer starr_33099 Neighboring gene chromogranin A Neighboring gene inositol 1,3,4-triphosphate 5/6 kinase Neighboring gene microRNA 1936

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genes induced by growth arrest in a pancreatic beta cell line: identification by analysis of cDNA arrays. Zimmer Y, et al. FEBS Lett, 1999 Aug 20. PMID 10486565
    2. Golga5 is dispensable for mouse embryonic development and postnatal survival. McGee LJ, et al. Genesis, 2017 Jul. PMID 28509431, Free PMC Article
    3. Golgin-84-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase. Jiang Q, et al. Neurobiol Aging, 2014 Jun. PMID 24368089
    4. Identification and characterization of golgin-84, a novel Golgi integral membrane protein with a cytoplasmic coiled-coil domain. Bascom RA, et al. J Biol Chem, 1999 Jan 29. PMID 9915833
    5. Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning. Mulder J, et al. Proc Natl Acad Sci U S A, 2008 Jun 24. PMID 18562289, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Golga5 is not required for mouse embryonic development, postnatal survival, or fertility.
      Title: Golga5 is dispensable for mouse embryonic development and postnatal survival.
    2. Its deficit is associated with Golgi fragmentation that induces tau hyperphosphorylation.
      Title: Golgin-84-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102087

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in Golgi vesicle transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi vesicle transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retrograde transport, vesicle recycling within Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, vesicle recycling within Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in COPI-coated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi cis cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cisterna IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi medial cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi trans cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    golgin subfamily A member 5
    Names
    golgi autoantigen golgin subfamily a5
    golgi autoantigen, golgin subfamily a, 5
    golgin-84
    protein Sumiko

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199004.1 → NP_001185933.1  golgin subfamily A member 5

      See identical proteins and their annotated locations for NP_001185933.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK138455, BC086782
      Consensus CDS
      CCDS36526.1
      UniProtKB/Swiss-Prot
      O88317, Q3TGE7, Q3U6S5, Q3UUF9, Q9QYE6
      Related
      ENSMUSP00000137305.2, ENSMUST00000179218.9
      Conserved Domains (2) summary
      COG1196
      Location:231 → 565
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09787
      Location:418 → 723
      Golgin_A5; Golgin subfamily A member 5

    2. NM_013747.4 → NP_038775.1  golgin subfamily A member 5

      See identical proteins and their annotated locations for NP_038775.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC086782
      Consensus CDS
      CCDS36526.1
      UniProtKB/Swiss-Prot
      O88317, Q3TGE7, Q3U6S5, Q3UUF9, Q9QYE6
      Related
      ENSMUSP00000021609.9, ENSMUST00000021609.10
      Conserved Domains (2) summary
      COG1196
      Location:231 → 565
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09787
      Location:418 → 723
      Golgin_A5; Golgin subfamily A member 5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      102435372..102464274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515935.5 → XP_006515998.1  golgin subfamily A member 5 isoform X1

      See identical proteins and their annotated locations for XP_006515998.1

      UniProtKB/Swiss-Prot
      O88317, Q3TGE7, Q3U6S5, Q3UUF9, Q9QYE6
      Conserved Domains (2) summary
      COG1196
      Location:231 → 565
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09787
      Location:418 → 723
      Golgin_A5; Golgin subfamily A member 5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYE6.2 GenPept UniProtKB/Swiss-Prot:Q9QYE6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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