Il18 interleukin 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il18provided by MGI
Official Full Name: interleukin 18provided by MGI
Primary source: MGI:MGI:107936
See related: Ensembl:ENSMUSG00000039217 AllianceGenome:MGI:107936
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Igif; Il-18
Summary: Enables cytokine activity. Involved in several processes, including cholesterol homeostasis; establishment of skin barrier; and positive regulation of cell differentiation. Acts upstream of or within several processes, including natural killer cell mediated cytotoxicity; negative regulation of myoblast differentiation; and positive regulation of type II interferon production. Is active in extracellular space. Is expressed in extraembryonic component; gut; lymphatic system; reproductive system; and trunk. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in colon adult (RPKM 9.4), cortex adult (RPKM 6.9) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 27.75 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (50466000..50493141)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (50554700..50581841)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTBP3 Mediates IL-18 Exon Skipping to Promote Immune Escape in Gallbladder Cancer.
Title: PTBP3 Mediates IL-18 Exon Skipping to Promote Immune Escape in Gallbladder Cancer.
A metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance.
Title: A metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance.
Role of IL-18 in adipose tissue remodeling and metabolic dysfunction.
Title: Role of IL-18 in adipose tissue remodeling and metabolic dysfunction.
Heat stress induces IL-1beta and IL-18 overproduction via ROS-activated NLRP3 inflammasome: implication in neuroinflammation in mice with heat stroke.
Title: Heat stress induces IL-1β and IL-18 overproduction via ROS-activated NLRP3 inflammasome: implication in neuroinflammation in mice with heat stroke.
Adipose tissue IL-18 production is independent of caspase-1 and caspase-11.
Title: Adipose tissue IL-18 production is independent of caspase-1 and caspase-11.
Molecular Mechanisms of IL18 in Disease.
Title: Molecular Mechanisms of IL18 in Disease.
Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer.
Title: Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer.
IL-18 serves as a main effector of CAF-derived METTL3 against immunosuppression of NSCLC via driving NF-kappaB pathway.
Title: IL-18 serves as a main effector of CAF-derived METTL3 against immunosuppression of NSCLC via driving NF-κB pathway.
CSF-1R+ Macrophages Control the Gut Microbiome-Enhanced Liver Invariant NKT Function through IL-18.
Title: CSF-1R+ Macrophages Control the Gut Microbiome-Enhanced Liver Invariant NKT Function through IL-18.
NLRP3 inflammasome-driven IL-1beta and IL-18 contribute to lipopolysaccharide-induced septic cardiomyopathy.
Title: NLRP3 inflammasome-driven IL-1β and IL-18 contribute to lipopolysaccharide-induced septic cardiomyopathy.

Submit: New GeneRIF Correction See all GeneRIFs (343)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (7) 1 citation

General gene information

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Markers

Il18 (e-PCR), detects polymorphism
- UniSTS:463948

Il18 (e-PCR), detects polymorphism
- UniSTS:525665

D49949 (e-PCR)
- UniSTS:159875

Il18 (e-PCR), detects polymorphism
- UniSTS:502663

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	ISS Inferred from Sequence or Structural Similarity more info
enables interleukin-18 receptor binding	ISO Inferred from Sequence Orthology more info
enables interleukin-18 receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within T-helper 1 cell cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within T-helper 1 cell cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in T-helper 1 type immune response	ISO Inferred from Sequence Orthology more info
involved_in T-helper 1 type immune response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to peptide hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in establishment of skin barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extrinsic apoptotic signaling pathway via death domain receptors	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within immune response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within interleukin-18-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-18-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-18-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within natural killer cell activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within natural killer cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neutrophil apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutrophil activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NK T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NK T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 cell cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T-helper 2 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel remodeling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-13 production	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of interleukin-17 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage derived foam cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of male germ cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of natural killer cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of type II interferon production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in sleep	ISO Inferred from Sequence Orthology more info
involved_in sleep	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of type II interferon production	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-18

Names: IFN-gamma-inducing factor; IL-1 gamma; interferon gamma-inducing factor; interleukin-1 gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357221.1 → NP_001344150.1 interleukin-18 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC025500, AC127254

Consensus CDS

CCDS40622.1

UniProtKB/Swiss-Prot

P70380

UniProtKB/TrEMBL

Q2PMY2, Q6USQ6

Related

ENSMUSP00000151002.2, ENSMUST00000214117.2

Conserved Domains (1) summary

cl00094
Location:76 → 182

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
NM_001357222.1 → NP_001344151.1 interleukin-18 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate coding exon in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AC025500, AC127254, AV328761

Consensus CDS

CCDS90562.1

UniProtKB/TrEMBL

A0A1L1STF5

Related

ENSMUSP00000150305.2, ENSMUST00000213916.2
NM_008360.2 → NP_032386.1 interleukin-18 isoform a

See identical proteins and their annotated locations for NP_032386.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC025500, AC127254, CX123286

Consensus CDS

CCDS40622.1

UniProtKB/Swiss-Prot

P70380

UniProtKB/TrEMBL

Q2PMY2, Q6USQ6

Conserved Domains (1) summary

cl00094
Location:76 → 182

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

50466000..50493141

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510024.1 → XP_006510087.1 interleukin-18 isoform X2

UniProtKB/TrEMBL

Q6USQ6

Conserved Domains (1) summary

cl00094
Location:96 → 202

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
XM_036154618.1 → XP_036010511.1 interleukin-18 isoform X4

UniProtKB/TrEMBL

Q80SS8

Conserved Domains (1) summary

cl00094
Location:60 → 166

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
XM_036154619.1 → XP_036010512.1 interleukin-18 isoform X4

UniProtKB/TrEMBL

Q80SS8

Conserved Domains (1) summary

cl00094
Location:60 → 166

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
XM_036154616.1 → XP_036010509.1 interleukin-18 isoform X2

UniProtKB/TrEMBL

Q6USQ6

Conserved Domains (1) summary

cl00094
Location:96 → 202

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
XM_030244066.2 → XP_030099926.1 interleukin-18 isoform X2

UniProtKB/TrEMBL

Q6USQ6

Conserved Domains (1) summary

cl00094
Location:96 → 202

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
XM_036154615.1 → XP_036010508.1 interleukin-18 isoform X1

Conserved Domains (1) summary

cl00094
Location:157 → 263

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
XM_017313137.3 → XP_017168626.1 interleukin-18 isoform X1

Conserved Domains (1) summary

cl00094
Location:157 → 263

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
XM_036154617.1 → XP_036010510.1 interleukin-18 isoform X3

UniProtKB/Swiss-Prot

P70380

UniProtKB/TrEMBL

Q2PMY2, Q6USQ6

Conserved Domains (1) summary

cl00094
Location:76 → 182

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).