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    DAPK2 death associated protein kinase 2 [ Homo sapiens (human) ]

    Gene ID: 23604, updated on 14-Nov-2024

    Summary

    Official Symbol
    DAPK2provided by HGNC
    Official Full Name
    death associated protein kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:2675
    See related
    Ensembl:ENSG00000035664 MIM:616567; AllianceGenome:HGNC:2675
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRP1; DRP-1
    Summary
    This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in thyroid (RPKM 7.0), lung (RPKM 4.4) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DAPK2 in Genome Data Viewer
    Location:
    15q22.31
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (63907036..64046485, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (61714186..61853651, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (64199235..64338684, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:63958187-63958357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64006953-64007452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64006451-64006952 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:64014173-64014349 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64057331-64058088 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64058904-64059404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6522 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:64107893-64108654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64114122-64114622 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64125303-64126168 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64126169-64127032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64171093-64171988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9543 Neighboring gene Sharpr-MPRA regulatory region 4498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64186155-64186656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9546 Neighboring gene microRNA 422a Neighboring gene uncharacterized LOC101928988 Neighboring gene Sharpr-MPRA regulatory region 12240 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64264631-64265378 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64277639-64278140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64290279-64290780 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9548 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:64318331-64318496 Neighboring gene NANOG hESC enhancer GRCh37_chr15:64330918-64331419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6525 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64342658-64343204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9552 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64385112-64385674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9556 Neighboring gene Sharpr-MPRA regulatory region 7733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9557 Neighboring gene cytosolic iron-sulfur assembly component 2A Neighboring gene sorting nexin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of death-associated protein kinase 2 (DAPK2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC119312

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in autophagosome lumen IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    death-associated protein kinase 2
    Names
    DAP kinase 2
    NP_001350659.1
    NP_001371926.1
    NP_001371927.1
    NP_001371928.1
    NP_001371929.1
    NP_001382208.1
    NP_001382210.1
    NP_001382211.1
    NP_001382212.1
    NP_001382213.1
    NP_001382214.1
    NP_001382215.1
    NP_001382216.1
    NP_001382217.1
    NP_001382218.1
    NP_001382219.1
    NP_001382220.1
    NP_001382221.1
    NP_001382222.1
    NP_055141.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363730.2NP_001350659.1  death-associated protein kinase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541, GU056176
      Consensus CDS
      CCDS86463.1
      Related
      ENSP00000484390.1, ENST00000612884.4
      Conserved Domains (1) summary
      cd14196
      Location:17285
      STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
    2. NM_001384997.1NP_001371926.1  death-associated protein kinase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
      Conserved Domains (1) summary
      cd14196
      Location:17285
      STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
    3. NM_001384998.1NP_001371927.1  death-associated protein kinase 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
      Conserved Domains (1) summary
      cl21453
      Location:17279
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001384999.1NP_001371928.1  death-associated protein kinase 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
      Conserved Domains (1) summary
      cl21453
      Location:17220
      PKc_like; Protein Kinases, catalytic domain
    5. NM_001385000.1NP_001371929.1  death-associated protein kinase 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
      Conserved Domains (1) summary
      cl21453
      Location:1130
      PKc_like; Protein Kinases, catalytic domain
    6. NM_001395279.1NP_001382208.1  death-associated protein kinase 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
      Conserved Domains (1) summary
      cd14196
      Location:17285
      STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
    7. NM_001395281.1NP_001382210.1  death-associated protein kinase 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
      Conserved Domains (1) summary
      cl21453
      Location:1130
      PKc_like; Protein Kinases, catalytic domain
    8. NM_001395282.1NP_001382211.1  death-associated protein kinase 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
      Conserved Domains (1) summary
      cl21453
      Location:17279
      PKc_like; Protein Kinases, catalytic domain
    9. NM_001395283.1NP_001382212.1  death-associated protein kinase 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
      Conserved Domains (1) summary
      cl21453
      Location:1124
      PKc_like; Protein Kinases, catalytic domain
    10. NM_001395284.1NP_001382213.1  death-associated protein kinase 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
      Conserved Domains (1) summary
      cl21453
      Location:1124
      PKc_like; Protein Kinases, catalytic domain
    11. NM_001395285.1NP_001382214.1  death-associated protein kinase 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
      Conserved Domains (1) summary
      cd14196
      Location:17285
      STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
    12. NM_001395286.1NP_001382215.1  death-associated protein kinase 2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
      UniProtKB/TrEMBL
      Q1RMF4
      Conserved Domains (1) summary
      cl21453
      Location:1130
      PKc_like; Protein Kinases, catalytic domain
    13. NM_001395287.1NP_001382216.1  death-associated protein kinase 2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
      UniProtKB/TrEMBL
      Q1RMF4
      Conserved Domains (1) summary
      cl21453
      Location:1130
      PKc_like; Protein Kinases, catalytic domain
    14. NM_001395288.1NP_001382217.1  death-associated protein kinase 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
      Conserved Domains (1) summary
      cd14196
      Location:17285
      STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
    15. NM_001395289.1NP_001382218.1  death-associated protein kinase 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
      Conserved Domains (1) summary
      cl21453
      Location:1124
      PKc_like; Protein Kinases, catalytic domain
    16. NM_001395290.1NP_001382219.1  death-associated protein kinase 2 isoform 13 precursor

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
      Conserved Domains (1) summary
      cl21453
      Location:176
      PKc_like; Protein Kinases, catalytic domain
    17. NM_001395291.1NP_001382220.1  death-associated protein kinase 2 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
      Conserved Domains (1) summary
      cd14196
      Location:17285
      STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
    18. NM_001395292.1NP_001382221.1  death-associated protein kinase 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
      Conserved Domains (1) summary
      cl21453
      Location:1130
      PKc_like; Protein Kinases, catalytic domain
    19. NM_001395293.1NP_001382222.1  death-associated protein kinase 2 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
      Conserved Domains (1) summary
      cd14196
      Location:17285
      STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
    20. NM_014326.5NP_055141.2  death-associated protein kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_055141.2

      Status: VALIDATED

      Source sequence(s)
      AB018001, AC015914, AC021541, AF052941
      Consensus CDS
      CCDS10188.1
      UniProtKB/Swiss-Prot
      E9JGM7, O75892, Q24JS1, Q9UIK4
      Related
      ENSP00000408277.1, ENST00000457488.6
      Conserved Domains (1) summary
      cd14196
      Location:17285
      STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

    RNA

    1. NR_169522.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
    2. NR_169523.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
    3. NR_169524.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541
    4. NR_172521.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      63907036..64046485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      61714186..61853651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)