MCM7 minichromosome maintenance complex component 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MCM7provided by HGNC
Official Full Name: minichromosome maintenance complex component 7provided by HGNC
Primary source: HGNC:HGNC:6950
See related: Ensembl:ENSG00000166508 MIM:600592; AllianceGenome:HGNC:6950
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MCM2; CDC47; P85MCM; P1CDC47; PNAS146; PPP1R104; P1.1-MCM3
Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 53.3), lymph node (RPKM 33.2) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q22.1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (100092728..100101397, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (101332574..101341242, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (99690351..99699020, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF8-mediated multi-ubiquitination of MCM7: Linking disassembly of the CMG helicase with DNA damage response in human cells.
Title: RNF8-mediated multi-ubiquitination of MCM7: Linking disassembly of the CMG helicase with DNA damage response in human cells.
Targeted inhibition of the expression of both MCM5 and MCM7 by miRNA-214 impedes DNA replication and tumorigenesis in hepatocellular carcinoma cells.
Title: Targeted inhibition of the expression of both MCM5 and MCM7 by miRNA-214 impedes DNA replication and tumorigenesis in hepatocellular carcinoma cells.
Homozygous mutation in MCM7 causes autosomal recessive primary microcephaly and intellectual disability.
Title: Homozygous mutation in MCM7 causes autosomal recessive primary microcephaly and intellectual disability.
MCM7 affects the cisplatin resistance of liver cancer cells and the development of liver cancer by regulating the PI3K/Akt signaling pathway.
Title: MCM7 affects the cisplatin resistance of liver cancer cells and the development of liver cancer by regulating the PI3K/Akt signaling pathway.
MCM complex members MCM3 and MCM7 are associated with a phenotypic spectrum from Meier-Gorlin syndrome to lipodystrophy and adrenal insufficiency.
Title: MCM complex members MCM3 and MCM7 are associated with a phenotypic spectrum from Meier-Gorlin syndrome to lipodystrophy and adrenal insufficiency.
miR-107 regulates the effect of MCM7 on the proliferation and apoptosis of colorectal cancer via the PAK2 pathway.
Title: miR-107 regulates the effect of MCM7 on the proliferation and apoptosis of colorectal cancer via the PAK2 pathway.
MCM2-7 complex is a novel druggable target for neuroendocrine prostate cancer.
Title: MCM2-7 complex is a novel druggable target for neuroendocrine prostate cancer.
The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids.
Title: The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids.
MCM7 silencing promotes cutaneous melanoma cell autophagy and apoptosis by inactivating the AKT1/mTOR signaling pathway.
Title: MCM7 silencing promotes cutaneous melanoma cell autophagy and apoptosis by inactivating the AKT1/mTOR signaling pathway.
MCM7 as a marker of postsurgical progression in non-functioning pituitary adenomas.
Title: MCM7 as a marker of postsurgical progression in non-functioning pituitary adenomas.

Submit: New GeneRIF Correction See all GeneRIFs (87)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify minichromosome maintenance complex component 7 isoform 1 (MCM7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify minichromosome maintenance complex component 7 isoform 1 (MCM7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify minichromosome maintenance complex component 7 isoform 1 (MCM7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pol	gag-pol	HIV-1 Pol is identified to have a physical interaction with minichromosome maintenance complex component 7 (MCM7) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
Pr55(Gag)	gag	Tandem affinity purification and mass spectrometry analysis identify minichromosome maintenance complex component 7 isoform 1 (MCM7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Tat	tat	Expression of HIV-1 Tat upregulates the abundance of minichromosome maintenance complex component 7 (MCM7) in the nucleoli of Jurkat T-cells	PubMed
	tat	Interaction of HIV-1 Tat with MCM7 in T-cells is identified by a proteomic strategy based on affinity chromatography	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-19563 (e-PCR)
- UniSTS:67073

RH78474 (e-PCR)
- UniSTS:37137

SHGC-144694 (e-PCR)
- UniSTS:172359

D7S2929 (e-PCR)
- UniSTS:33096

RH65692 (e-PCR)
- UniSTS:23889

RH47672 (e-PCR)
- UniSTS:21589

RH128042 (e-PCR)
- UniSTS:211350

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
contributes_to DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
contributes_to DNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables forked DNA-dependent helicase activity	IEA Inferred from Electronic Annotation more info
enables four-way junction helicase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info
contributes_to single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
contributes_to single-stranded DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA replication	TAS Traceable Author Statement more info	PubMed
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA strand elongation involved in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA unwinding involved in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA unwinding involved in DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to epidermal growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via break-induced replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated DNA replication initiation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CMG complex	IPI Inferred from Physical Interaction more info	PubMed
part_of CMG complex	ISS Inferred from Sequence or Structural Similarity more info
part_of MCM complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MCM complex	IDA Inferred from Direct Assay more info	PubMed
part_of MCM complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of MCM complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromatin	TAS Traceable Author Statement more info	PubMed
located_in chromosome, telomeric region	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in membrane	HDA more info	PubMed
NOT located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DNA replication licensing factor MCM7

Names: CDC47 homolog; homolog of S. cerevisiae Cdc47; minichromosome maintenance deficient 7; protein phosphatase 1, regulatory subunit 104

NP_001265524.1

EC 3.6.4.12

NP_005907.3

EC 3.6.4.12

NP_877577.1

EC 3.6.4.12

XP_005250405.1

EC 3.6.4.12

XP_054214227.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278595.2 → NP_001265524.1 DNA replication licensing factor MCM7 isoform 2

See identical proteins and their annotated locations for NP_001265524.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an additional internal segment, which results in translation initiation from an in-frame downstream AUG compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.

Source sequence(s)

AC073842

Consensus CDS

CCDS5684.1

UniProtKB/TrEMBL

B3KUD7

Related

ENST00000489841.6

Conserved Domains (2) summary

smart00350
Location:1 → 465

MCM; minichromosome maintenance proteins

cl21455
Location:200 → 339

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_005916.5 → NP_005907.3 DNA replication licensing factor MCM7 isoform 1

See identical proteins and their annotated locations for NP_005907.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC073842

Consensus CDS

CCDS5683.1

UniProtKB/Swiss-Prot

A4D2A1, A4D2A2, E9PGN9, P33993, Q15076, Q96D34, Q96GL1

UniProtKB/TrEMBL

A0A0S2Z4A5, B2RBA6

Related

ENSP00000307288.5, ENST00000303887.10

Conserved Domains (2) summary

smart00350
Location:145 → 641

MCM; minichromosome maintenance proteins

pfam14551
Location:10 → 93

MCM_N; MCM N-terminal domain
NM_182776.3 → NP_877577.1 DNA replication licensing factor MCM7 isoform 2

See identical proteins and their annotated locations for NP_877577.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs at the 5' end, contains an additional internal segment, and initiates translation from an in-frame downstream AUG compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.

Source sequence(s)

AK055379, AK226175

Consensus CDS

CCDS5684.1

UniProtKB/TrEMBL

B3KUD7

Related

ENST00000485286.6

Conserved Domains (2) summary

smart00350
Location:1 → 465

MCM; minichromosome maintenance proteins

cl21455
Location:200 → 339

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

100092728..100101397 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005250348.4 → XP_005250405.1 DNA replication licensing factor MCM7 isoform X1

UniProtKB/TrEMBL

B3KUD7, C9J8M6

Related

ENSP00000411295.2, ENST00000425308.6

Conserved Domains (3) summary

smart00350
Location:38 → 534

MCM; minichromosome maintenance proteins

pfam14551
Location:11 → 58

MCM_N; MCM N-terminal domain

cl21455
Location:269 → 408

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases