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    Neil1 nei endonuclease VIII-like 1 (E. coli) [ Mus musculus (house mouse) ]

    Gene ID: 72774, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Neil1provided by MGI
    Official Full Name
    nei endonuclease VIII-like 1 (E. coli)provided by MGI
    Primary source
    MGI:MGI:1920024
    See related
    Ensembl:ENSMUSG00000032298 AllianceGenome:MGI:1920024
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NEH1; Nei1; 2810450N13Rik
    Summary
    Enables DNA N-glycosylase activity and lyase activity. Acts upstream of or within DNA repair. Located in nucleus. Is expressed in ductus deferens; embryo; epididymis; and metanephros. Used to study abdominal obesity-metabolic syndrome and obesity. Orthologous to human NEIL1 (nei like DNA glycosylase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 13.5), mammary gland adult (RPKM 5.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Neil1 in Genome Data Viewer
    Location:
    9 B; 9 30.89 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57050072..57055973, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57142788..57148688, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2700012I20 gene Neighboring gene STARR-positive B cell enhancer ABC_E9329 Neighboring gene STARR-positive B cell enhancer ABC_E711 Neighboring gene transcriptional regulator, SIN3A (yeast) Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56978348-56978531 Neighboring gene STARR-positive B cell enhancer ABC_E3832 Neighboring gene mannosidase, alpha, class 2C, member 1, opposite strand Neighboring gene mannosidase, alpha, class 2C, member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56995851-56996034 Neighboring gene STARR-positive B cell enhancer ABC_E5070 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57006119-57006228 Neighboring gene COMM domain containing 4 Neighboring gene RIKEN cDNA 1700041C23 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress. Yang B, et al. Free Radic Biol Med, 2019 Sep. PMID 31175982, Free PMC Article
    2. Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice. Canugovi C, et al. Proc Natl Acad Sci U S A, 2012 Sep 11. PMID 22927410, Free PMC Article
    3. Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice. Møllersen L, et al. Hum Mol Genet, 2012 Nov 15. PMID 22914735, Free PMC Article
    4. NEIL1 mRNA splicing variants are expressed in normal mouse organs. Yamamoto R, et al. J Radiat Res, 2012. PMID 22510596
    5. Hypersensitivity of mouse NEIL1-knockdown cells to hydrogen peroxide during S phase. Yamamoto R, et al. J Radiat Res, 2014 Jul. PMID 24706997, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1.
      Title: NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1.
    2. NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.
      Title: NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.
    3. DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model.
      Title: DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model.
    4. Enzymatic Hydroxylation and Excision of Extended 5-Methylcytosine Analogues.
      Title: Enzymatic Hydroxylation and Excision of Extended 5-Methylcytosine Analogues.
    5. The DNA glycosylase, Neil1, promotes successful hippocampal neurogenesis and learning and memory in young-adult mice.
      Title: Endonuclease VIII-like 1 deficiency impairs survival of newly generated hippocampal neurons and memory performance in young-adult male mice.
    6. NEIL1 plays an important role in adult mouse neurogenesis and in the resolution of neuroinflammation
      Title: NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress.
    7. Thus, NEIL1 and NEIL2 DNA glycosylases protect mitochondrial DNA against oxidative damage during neural crest differentiation.
      Title: NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress.
    8. Loss of Neil1 expression is associated with hepatocellular carcinoma.
      Title: NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice.
    9. Collectively the data suggest that NEIL1-initiated repair of a subset of ROS-induced DNA base lesions may be insufficient to prevent the initiation of inflammatory pathways during chronic UV exposure in mouse skin.
      Title: Enhanced sensitivity of Neil1(-/-) mice to chronic UVB exposure.
    10. Its loss causes defects in olfactory function.
      Title: Loss of NEIL1 causes defects in olfactory function in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in base-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of nuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    endonuclease 8-like 1
    Names
    DNA glycosylase/AP lyase Neil1
    DNA-(apurinic or apyrimidinic site) lyase Neil1
    endonuclease VIII
    endonuclease VIII-like 1
    nei homolog 1
    nei-like protein 1
    NP_001344338.1
    NP_082623.1
    XP_006511548.1
    XP_006511549.1
    XP_006511550.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357409.1 → NP_001344338.1  endonuclease 8-like 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC132406
      UniProtKB/TrEMBL
      Q3U296
      Conserved Domains (3) summary
      pfam09292
      Location:189 → 227
      Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
      cl03119
      Location:1 → 52
      FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases
      cl26942
      Location:52 → 158
      H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain

    2. NM_028347.3 → NP_082623.1  endonuclease 8-like 1 isoform 1

      See identical proteins and their annotated locations for NP_082623.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC132406, AK013322, BC034873
      Consensus CDS
      CCDS23217.1
      UniProtKB/Swiss-Prot
      Q80V58, Q8K4Q6, Q9CYT9
      Related
      ENSMUSP00000139917.2, ENSMUST00000190245.7
      Conserved Domains (3) summary
      TIGR00577
      Location:52 → 221
      fpg; DNA-formamidopyrimidine glycosylase
      pfam09292
      Location:252 → 290
      Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
      cl03119
      Location:1 → 127
      FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases

    RNA

    1. NR_151685.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC132406

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      57050072..57055973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511485.5 → XP_006511548.1  endonuclease 8-like 1 isoform X1

      See identical proteins and their annotated locations for XP_006511548.1

      UniProtKB/Swiss-Prot
      Q80V58, Q8K4Q6, Q9CYT9
      Conserved Domains (3) summary
      TIGR00577
      Location:52 → 221
      fpg; DNA-formamidopyrimidine glycosylase
      pfam09292
      Location:252 → 290
      Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
      cl03119
      Location:1 → 127
      FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases

    2. XM_006511487.5 → XP_006511550.1  endonuclease 8-like 1 isoform X2

      Conserved Domains (2) summary
      pfam09292
      Location:212 → 250
      Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
      cl03119
      Location:1 → 127
      FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases

    3. XM_006511486.4 → XP_006511549.1  endonuclease 8-like 1 isoform X1

      See identical proteins and their annotated locations for XP_006511549.1

      UniProtKB/Swiss-Prot
      Q80V58, Q8K4Q6, Q9CYT9
      Related
      ENSMUSP00000034842.5, ENSMUST00000034842.5
      Conserved Domains (3) summary
      TIGR00577
      Location:52 → 221
      fpg; DNA-formamidopyrimidine glycosylase
      pfam09292
      Location:252 → 290
      Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
      cl03119
      Location:1 → 127
      FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases

    RNA

    1. XR_003948020.2 RNA Sequence

    2. XR_003948019.2 RNA Sequence

    3. XR_379461.5 RNA Sequence

    4. XR_004935575.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4Q6.3 GenPept UniProtKB/Swiss-Prot:Q8K4Q6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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