U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Lrp1b low density lipoprotein-related protein 1B [ Mus musculus (house mouse) ]

    Gene ID: 94217, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Lrp1bprovided by MGI
    Official Full Name
    low density lipoprotein-related protein 1Bprovided by MGI
    Primary source
    MGI:MGI:2151136
    See related
    Ensembl:ENSMUSG00000049252 AllianceGenome:MGI:2151136
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LRP-DIT; 9630004P12Rik
    Summary
    Enables low-density lipoprotein particle receptor activity. Acts upstream of or within in utero embryonic development. Located in membrane. Is expressed in several structures, including central nervous system and eye. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung disease (multiple); and melanoma. Orthologous to human LRP1B (LDL receptor related protein 1B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 1.7), cortex adult (RPKM 1.4) and 4 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Lrp1b in Genome Data Viewer
    Location:
    2 B; 2 24.51 cM
    Exon count:
    93
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (40485302..42543747, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (40595290..42653598, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04359 Neighboring gene STARR-seq mESC enhancer starr_04361 Neighboring gene predicted gene, 24467 Neighboring gene STARR-seq mESC enhancer starr_04362 Neighboring gene STARR-seq mESC enhancer starr_04363 Neighboring gene STARR-seq mESC enhancer starr_04364 Neighboring gene STARR-positive B cell enhancer mm9_chr2:40476998-40477299 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04365 Neighboring gene STARR-seq mESC enhancer starr_04366 Neighboring gene STARR-seq mESC enhancer starr_04367 Neighboring gene STARR-seq mESC enhancer starr_04368 Neighboring gene ash2 (absent, small, or homeotic)-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_04370 Neighboring gene STARR-seq mESC enhancer starr_04372 Neighboring gene predicted gene, 30138 Neighboring gene STARR-seq mESC enhancer starr_04373 Neighboring gene STARR-seq mESC enhancer starr_04374 Neighboring gene STARR-seq mESC enhancer starr_04375 Neighboring gene STARR-seq mESC enhancer starr_04376 Neighboring gene STARR-seq mESC enhancer starr_04377 Neighboring gene RAN, member RAS oncogene family, pseudogene Neighboring gene microRNA 6336 Neighboring gene STARR-seq mESC enhancer starr_04378 Neighboring gene STARR-seq mESC enhancer starr_04379 Neighboring gene STARR-seq mESC enhancer starr_04380 Neighboring gene STARR-seq mESC enhancer starr_04381 Neighboring gene predicted gene, 24350 Neighboring gene predicted gene, 39803

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that overexpression of full-length mouse Lrp1b leads to impaired cellular proliferation, while human LRP1B knockdown has the opposite effect.
      Title: Expression of a recombinant full-length LRP1B receptor in human non-small cell lung cancer cells confirms the postulated growth-suppressing function of this large LDL receptor family member.
    2. C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity
      Title: C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity.
    3. the extracellular domains may function as a scavenger for signaling ligands or signal modulators in the extracellular space, thereby preserving signaling thresholds that are critical for embryonic development
      Title: Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.
    4. This study presents the possibility that LRP1B participates in signal transduction which PICK1 may regulate by inhibiting PKCalpha phosphorylation of LRP1B.
      Title: Identification of LRP1B-interacting proteins and inhibition of protein kinase Calpha-phosphorylation of LRP1B by association with PICK1.
    5. both halves of the LRP1B cytoplasmic tail contribute to a unique global conformation, which results in less efficient recognition by endocytic adaptors and a slow endocytosis rate.
      Title: Slow endocytosis of the LDL receptor-related protein 1B: implications for a novel cytoplasmic tail conformation.
    6. Results show that in contrast to LRP1, LRP1b-deficient mice develop normally, most likely due to its restricted expression pattern and functional compensation by LRP1 or other receptors.
      Title: Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables low-density lipoprotein particle receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables low-density lipoprotein particle receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    low-density lipoprotein receptor-related protein 1B
    Names
    LRP-1B
    low density lipoprotein-related protein 1B (deleted in tumors)
    low-density lipoprotein receptor-related protein-deleted in tumor

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053011.2 → NP_443737.2  low-density lipoprotein receptor-related protein 1B precursor

      Status: VALIDATED

      Source sequence(s)
      AL805948, AL840626, AL844225, AL844515, AL844533, AL844553, AL845293, AL928732, AL928962, AL928981, BX000439, BX649304
      Consensus CDS
      CCDS84520.1
      UniProtKB/Swiss-Prot
      Q8BZD3, Q8BZM7, Q9JI18
      UniProtKB/TrEMBL
      A2API5
      Related
      ENSMUSP00000054275.8, ENSMUST00000052550.13
      Conserved Domains (11) summary
      smart00192
      Location:926 → 958
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:1947 → 1987
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:2968 → 3002
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:4250 → 4284
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00112
      Location:3476 → 3510
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:1913 → 1952
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:1100 → 1131
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:2330 → 2371
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam12662
      Location:2948 → 2971
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:3277 → 3313
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl18310
      Location:1913 → 2138
      NHL; NHL repeat unit of beta-propeller proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      40485302..42543747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498463.5 → XP_006498526.1  low-density lipoprotein receptor-related protein 1B isoform X5

      UniProtKB/Swiss-Prot
      Q8BZD3, Q8BZM7, Q9JI18
      Conserved Domains (12) summary
      smart00192
      Location:957 → 989
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:1978 → 2018
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:2918 → 2952
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:4200 → 4234
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00112
      Location:3426 → 3460
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:1944 → 1983
      NHL; NHL repeat [structural motif]
      pfam00058
      Location:2361 → 2402
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl18310
      Location:1944 → 2169
      NHL; NHL repeat unit of beta-propeller proteins
      pfam00057
      Location:1131 → 1162
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam12662
      Location:2898 → 2921
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:3227 → 3263
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl39070
      Location:3989 → 4029
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B

    2. XM_017319348.3 → XP_017174837.1  low-density lipoprotein receptor-related protein 1B isoform X3

      UniProtKB/Swiss-Prot
      Q8BZD3, Q8BZM7, Q9JI18
      Conserved Domains (12) summary
      smart00192
      Location:957 → 989
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:1978 → 2018
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:2999 → 3033
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:4238 → 4272
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00112
      Location:3507 → 3541
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:1944 → 1983
      NHL; NHL repeat [structural motif]
      pfam00058
      Location:2361 → 2402
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl18310
      Location:1944 → 2169
      NHL; NHL repeat unit of beta-propeller proteins
      pfam00057
      Location:1131 → 1162
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam12662
      Location:2979 → 3002
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:3308 → 3344
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl39070
      Location:4027 → 4067
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B

    3. XM_006498462.5 → XP_006498525.1  low-density lipoprotein receptor-related protein 1B isoform X4

      UniProtKB/Swiss-Prot
      Q8BZD3, Q8BZM7, Q9JI18
      Conserved Domains (12) summary
      smart00192
      Location:957 → 989
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:1978 → 2018
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:2999 → 3033
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:4281 → 4315
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00112
      Location:3507 → 3541
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:1944 → 1983
      NHL; NHL repeat [structural motif]
      pfam00058
      Location:2361 → 2402
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl18310
      Location:1944 → 2169
      NHL; NHL repeat unit of beta-propeller proteins
      pfam00057
      Location:1131 → 1162
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam12662
      Location:2979 → 3002
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:3308 → 3344
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl39070
      Location:4070 → 4110
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B

    4. XM_006498460.5 → XP_006498523.1  low-density lipoprotein receptor-related protein 1B isoform X2

      UniProtKB/Swiss-Prot
      Q8BZD3, Q8BZM7, Q9JI18
      Conserved Domains (12) summary
      smart00192
      Location:957 → 989
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:1978 → 2018
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:2999 → 3033
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:4281 → 4315
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00112
      Location:3507 → 3541
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:1944 → 1983
      NHL; NHL repeat [structural motif]
      pfam00058
      Location:2361 → 2402
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl18310
      Location:1944 → 2169
      NHL; NHL repeat unit of beta-propeller proteins
      pfam00057
      Location:1131 → 1162
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam12662
      Location:2979 → 3002
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:3308 → 3344
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl39070
      Location:4070 → 4110
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B

    5. XM_006498459.5 → XP_006498522.1  low-density lipoprotein receptor-related protein 1B isoform X1

      UniProtKB/Swiss-Prot
      Q8BZD3, Q8BZM7, Q9JI18
      Conserved Domains (12) summary
      smart00192
      Location:957 → 989
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:1978 → 2018
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:2999 → 3033
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:4281 → 4315
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00112
      Location:3507 → 3541
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:1944 → 1983
      NHL; NHL repeat [structural motif]
      pfam00058
      Location:2361 → 2402
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl18310
      Location:1944 → 2169
      NHL; NHL repeat unit of beta-propeller proteins
      pfam00057
      Location:1131 → 1162
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam12662
      Location:2979 → 3002
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:3308 → 3344
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl39070
      Location:4070 → 4110
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B

    6. XM_011239217.4 → XP_011237519.1  low-density lipoprotein receptor-related protein 1B isoform X6

      Conserved Domains (8) summary
      smart00192
      Location:957 → 989
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:1978 → 2018
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:1084 → 1119
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:1944 → 1983
      NHL; NHL repeat [structural motif]
      pfam00058
      Location:2361 → 2402
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl18310
      Location:1944 → 2169
      NHL; NHL repeat unit of beta-propeller proteins
      pfam00057
      Location:997 → 1033
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam14670
      Location:1207 → 1243
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RNA

    1. XR_374143.5 RNA Sequence

    2. XR_374144.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JI18.1 GenPept UniProtKB/Swiss-Prot:Q9JI18

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools