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    foxp1a forkhead box P1a [ Danio rerio (zebrafish) ]

    Gene ID: 564127, updated on 2-Nov-2024

    Summary

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    Official Symbol
    foxp1aprovided by ZNC
    Official Full Name
    forkhead box P1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060929-624
    See related
    Ensembl:ENSDARG00000004843 AllianceGenome:ZFIN:ZDB-GENE-060929-624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7146611; wu:fb97f01; zgc:154010
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in brain; dorsal telencephalon; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; congenital heart disease; esophagus adenocarcinoma; intellectual disability-severe speech delay-mild dysmorphism syndrome; and peritonitis. Orthologous to human FOXP1 (forkhead box P1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See foxp1a in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (10638009..10722731, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (10703039..10787772, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101882287 Neighboring gene uncharacterized LOC101882326 Neighboring gene eukaryotic translation initiation factor 4E family member 3 Neighboring gene uncharacterized LOC110438311

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates. Lu X, et al. Cell Res, 2013 Dec. PMID 24165894, Free PMC Article
    2. Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish-implications for neurodevelopmental disorders. Lüffe TM, et al. Transl Psychiatry, 2021 Oct 14. PMID 34650032, Free PMC Article
    3. Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain. Ahi EP, et al. Fish Physiol Biochem, 2021 Aug. PMID 34236575, Free PMC Article
    4. Top2a promotes the development of social behavior via PRC2 and H3K27me3. Geng Y, et al. Sci Adv, 2022 Nov 25. PMID 36417527, Free PMC Article
    5. Bone morphogenetic protein signaling governs biliary-driven liver regeneration in zebrafish through tbx2b and id2a. Choi TY, et al. Hepatology, 2017 Nov. PMID 28599080, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC154010, MGC193059

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    forkhead box protein P1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077564.2 → NP_001071032.2  forkhead box protein P1a

      Status: VALIDATED

      Source sequence(s)
      BC124513, CR388366, EE696076
      UniProtKB/TrEMBL
      A0A8M1NBT2, F1Q4T2
      Related
      ENSDARP00000107924.2, ENSDART00000129022.4
      Conserved Domains (2) summary
      cd00059
      Location:428 → 500
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      pfam16159
      Location:264 → 331
      FOXP-CC; FOXP coiled-coil domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      10638009..10722731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469823.2 → XP_021325498.1  forkhead box protein P1a isoform X3

      UniProtKB/TrEMBL
      A0A8M9PF34
      Conserved Domains (2) summary
      cd00059
      Location:395 → 467
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      pfam16159
      Location:231 → 298
      FOXP-CC; FOXP coiled-coil domain

    2. XM_021469822.2 → XP_021325497.1  forkhead box protein P1a isoform X2

      UniProtKB/TrEMBL
      A0A8M9P554
      Conserved Domains (2) summary
      cd00059
      Location:396 → 468
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      pfam16159
      Location:232 → 299
      FOXP-CC; FOXP coiled-coil domain

    3. XM_005161959.4 → XP_005162016.1  forkhead box protein P1a isoform X1

      UniProtKB/TrEMBL
      A0A2R8Q1R5, A0A8M2B8V0
      Related
      ENSDARP00000146482.1, ENSDART00000189721.1
      Conserved Domains (2) summary
      cd00059
      Location:429 → 501
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      pfam16159
      Location:265 → 332
      FOXP-CC; FOXP coiled-coil domain

    4. XM_005161960.5 → XP_005162017.1  forkhead box protein P1a isoform X4

      See identical proteins and their annotated locations for XP_005162017.1

      UniProtKB/TrEMBL
      A0A8M2B938
      Conserved Domains (2) summary
      cd00059
      Location:344 → 416
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      pfam16159
      Location:180 → 247
      FOXP-CC; FOXP coiled-coil domain
    Nucleotide Protein Strain
    Heading Accession and Version

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