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    Cd163 CD163 antigen [ Mus musculus (house mouse) ]

    Gene ID: 93671, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cd163provided by MGI
    Official Full Name
    CD163 antigenprovided by MGI
    Primary source
    MGI:MGI:2135946
    See related
    Ensembl:ENSMUSG00000008845 AllianceGenome:MGI:2135946
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD163v2; CD163v3
    Summary
    Predicted to enable scaffold protein binding activity and scavenger receptor activity. Predicted to be involved in acute-phase response and vesicle-mediated transport. Predicted to be located in cell surface and plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; immune system; male reproductive gland or organ; olfactory lobe; and quadriceps femoris muscle. Orthologous to human CD163 (CD163 molecule). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 2.4), subcutaneous fat pad adult (RPKM 2.3) and 20 other tissues See more
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    Genomic context

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    See Cd163 in Genome Data Viewer
    Location:
    6 F2; 6 59.13 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124281596..124307488)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124304636..124330529)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene Neighboring gene predicted gene, 25311 Neighboring gene predicted gene, 52877 Neighboring gene RIKEN cDNA 1700013D24 gene Neighboring gene RIKEN cDNA 1700027F06 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CD163(+) Macrophages Induce Endothelial-to-Mesenchymal Transition in Atheroma. Mori M, et al. Circ Res, 2024 Jul 5. PMID 38860377
    2. Assignment of the CD163 antigen (CD163) to mouse chromosome 6 band F2 by radiation hybrid mapping. Schaer DJ, et al. Cytogenet Genome Res, 2002. PMID 12698011
    3. Molecular cloning and characterization of the mouse CD163 homologue, a highly glucocorticoid-inducible member of the scavenger receptor cysteine-rich family. Schaer DJ, et al. Immunogenetics, 2001 Mar. PMID 11345593
    4. Plasma clearance of hemoglobin and haptoglobin in mice and effect of CD163 gene targeting disruption. Etzerodt A, et al. Antioxid Redox Signal, 2013 Jun 10. PMID 22793784
    5. The absence of the CD163 receptor has distinct temporal influences on intracerebral hemorrhage outcomes. Leclerc JL, et al. J Cereb Blood Flow Metab, 2018 Feb. PMID 28358264, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD163[+] Macrophages Induce Endothelial-to-Mesenchymal Transition in Atheroma.
      Title: CD163(+) Macrophages Induce Endothelial-to-Mesenchymal Transition in Atheroma.
    2. TREM2 and CD163 Ameliorate Microglia-Mediated Inflammatory Environment in the Aging Brain.
      Title: TREM2 and CD163 Ameliorate Microglia-Mediated Inflammatory Environment in the Aging Brain.
    3. ANGPTL4 regulates CD163 expression and Kuppfer cell polarization induced cirrhosis via TLR4/NF-kappaB pathway.
      Title: ANGPTL4 regulates CD163 expression and Kuppfer cell polarization induced cirrhosis via TLR4/NF-κB pathway.
    4. CD163 deficiency increases foam cell formation and plaque progression in atherosclerotic mice.
      Title: CD163 deficiency increases foam cell formation and plaque progression in atherosclerotic mice.
    5. Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis.
      Title: Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis.
    6. Study observed macrophage-induced tumor cell proliferation in cocultures of human monocyte-derived macrophages and leiomyosarcoma and myxofibrosarcoma human and mouse cell lines, which was abrogated by silencing of CD163. Tumor development of sarcoma cells in CD163-deficient mice was significantly abrogated in comparison with wild-type mice.
      Title: CD163 Is Required for Protumoral Activation of Macrophages in Human and Murine Sarcoma.
    7. CD163 has a role in angiogenesis and vascular permeability with inflammation in atherosclerosis
      Title: CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis.
    8. While it is unclear why CD163 deficiency is initially beneficial, the late injurious effects are consistent with the key anti-inflammatory role of CD163 in the recovery phase of tissue damage
      Title: The absence of the CD163 receptor has distinct temporal influences on intracerebral hemorrhage outcomes.
    9. house dust mite -challenged Cd163-/- mice displayed increases in airway eosinophils and mucous cell metaplasia
      Title: A CCL24-dependent pathway augments eosinophilic airway inflammation in house dust mite-challenged Cd163(-/-) mice.
    10. In diabetic mice, increased sCD163 at wk 5 and decreased percentage of CD163(+) monocytes at wk 10 preceded alteration in kidney collagen IV mRNA at wk 20. In vitro incubation of monocytes in anti-inflammatory glucocorticoid increased the percentage of CD163(+) monocytes.
      Title: Monocyte CD163 is altered in association with diabetic complications: possible protective role.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables scaffold protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables scavenger receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acute-phase response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    scavenger receptor cysteine-rich type 1 protein M130

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170395.1 → NP_001163866.1  scavenger receptor cysteine-rich type 1 protein M130 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001163866.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC124470
      Consensus CDS
      CCDS51905.1
      UniProtKB/TrEMBL
      B7ZMW6
      Related
      ENSMUSP00000108160.3, ENSMUST00000112541.8
      Conserved Domains (2) summary
      smart00202
      Location:719 → 819
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:724 → 819
      SRCR; Scavenger receptor cysteine-rich domain

    2. NM_053094.2 → NP_444324.2  scavenger receptor cysteine-rich type 1 protein M130 isoform 2 precursor

      See identical proteins and their annotated locations for NP_444324.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AC124470
      Consensus CDS
      CCDS20516.1
      UniProtKB/Swiss-Prot
      A6H691, Q2VLH5, Q2VLH6, Q99MX8
      Related
      ENSMUSP00000032234.3, ENSMUST00000032234.5
      Conserved Domains (2) summary
      smart00202
      Location:719 → 819
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:724 → 819
      SRCR; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      124281596..124307488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506800.5 → XP_006506863.1  scavenger receptor cysteine-rich type 1 protein M130 isoform X1

      Conserved Domains (1) summary
      smart00202
      Location:691 → 791
      SR; Scavenger receptor Cys-rich
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2VLH6.2 GenPept UniProtKB/Swiss-Prot:Q2VLH6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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