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    clcn3.S chloride channel, voltage-sensitive 3 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 399089, updated on 17-Aug-2024

    Summary

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    Official Symbol
    clcn3.S
    Official Full Name
    chloride channel, voltage-sensitive 3 S homeolog
    Primary source
    Xenbase:XB-GENE-950797
    Locus tag
    XELAEV_18009167mg
    See related
    EnsemblRapid:ENSXLAG00005001190
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    clc3; clc-3; clcn3
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    Genomic context

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    Location:
    chromosome: 1S
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (39095856..39143183, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (38837255..38884614, complement)

    Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene aminoadipate aminotransferase S homeolog Neighboring gene microfibril associated protein 3 like S homeolog Neighboring gene NIMA-related kinase 1 S homeolog Neighboring gene SH3 domain containing ring finger 1 S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Possible roles of ENaC and Cl(-) channel in wound closure in Xenopus laevis embryos. Fuchigami T, et al. Zoolog Sci, 2011 Oct. PMID 21967216
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables voltage-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chloride channel, voltage-sensitive 3 S homeolog
    Names
    chloride channel 3
    putative chloride channel ClC-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001090267.1 → NP_001083736.1  chloride channel, voltage-sensitive 3 S homeolog

      See identical proteins and their annotated locations for NP_001083736.1

      Status: PROVISIONAL

      Source sequence(s)
      Y09941
      UniProtKB/TrEMBL
      A0A974I0I9, A5PKR3, Q9YH11
      Related
      ENSXLAP00005003635.1, ENSXLAT00005003697.1
      Conserved Domains (4) summary
      COG0517
      Location:628 → 774
      CBS; CBS domain [Signal transduction mechanisms]
      cd03684
      Location:109 → 615
      ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
      cd04591
      Location:638 → 776
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      pfam00654
      Location:194 → 595
      Voltage_CLC; Voltage gated chloride channel

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      39095856..39143183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018234706.2 → XP_018090195.1  chloride channel, voltage-sensitive 3 S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A8J0TUZ0, A0A974I0I9, A5PKR3
      Related
      ENSXLAP00005003647.1, ENSXLAT00005003709.1

    2. XM_018234730.2 → XP_018090219.1  chloride channel, voltage-sensitive 3 S homeolog isoform X3

      UniProtKB/TrEMBL
      A0A8J0TSR8, A0A974I0I9, A5PKR3
      Related
      ENSXLAP00005003644.1, ENSXLAT00005003706.1

    3. XM_018234720.2 → XP_018090209.1  chloride channel, voltage-sensitive 3 S homeolog isoform X2

      UniProtKB/TrEMBL
      A0A8J0TV01, A0A974I0I9, A5PKR3
    Nucleotide Protein Strain
    Heading Accession and Version

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