Pak6 p21 (RAC1) activated kinase 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pak6provided by MGI
Official Full Name: p21 (RAC1) activated kinase 6provided by MGI
Primary source: MGI:MGI:2679420
See related: Ensembl:ENSMUSG00000074923 AllianceGenome:MGI:2679420
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4732456M09
Summary: Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within learning or memory; locomotory behavior; and neuron projection morphogenesis. Is active in postsynaptic density. Is expressed in several structures, including central nervous system; liver; retina; submandibular gland primordium; and tooth. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to several human genes including PAK6 (p21 (RAC1) activated kinase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in adrenal adult (RPKM 13.2), CNS E18 (RPKM 12.7) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 59.41 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (118493531..118528501)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (118663045..118698020)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p21-activated kinase 6 (PAK6) as a novel interactor of leucine-rich repeat kinase 2 (LRRK2), a kinase involved in Parkinson's disease
Title: Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.
data suggest that PAK-6 p21-activated kinase plays a role in weight gain unrelated to exercise and caloric intake
Title: Differential sensitivity of Pak5, Pak6, and Pak5/Pak6 double-knockout mice to the stimulant effects of amphetamine and exercise-induced alterations in body weight.
functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice
Title: Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice.
Our results indicate that Pak5 and Pak6 together are not required for viability, but are required for a normal level of locomotion and activity as well as for learning and memory.
Title: Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G36414 (e-PCR)
- UniSTS:64547

RH131540 (e-PCR)
- UniSTS:214823

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within learning	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within memory	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron projection arborization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron projection extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	EXP Inferred from Experiment more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase PAK 6

Names: PAK-6; p21 protein (Cdc42/Rac)-activated kinase 6; p21-activated kinase 6

NP_001028426.2

EC 2.7.11.1

NP_001139326.1

EC 2.7.11.1

NP_001411690.1

EC 2.7.11.1

NP_001411691.1

EC 2.7.11.1

XP_011237721.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033254.4 → NP_001028426.2 serine/threonine-protein kinase PAK 6

See identical proteins and their annotated locations for NP_001028426.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Both variants encode the same protein.

Source sequence(s)

AL845470

Consensus CDS

CCDS16580.1

UniProtKB/Swiss-Prot

Q3TY26, Q3ULB5

UniProtKB/TrEMBL

B2RWY1

Related

ENSMUSP00000097153.4, ENSMUST00000099557.10

Conserved Domains (2) summary

cd06659
Location:386 → 682

STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6

pfam00786
Location:11 → 63

PBD; P21-Rho-binding domain
NM_001145854.2 → NP_001139326.1 serine/threonine-protein kinase PAK 6

See identical proteins and their annotated locations for NP_001139326.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.

Source sequence(s)

AL845470

Consensus CDS

CCDS16580.1

UniProtKB/Swiss-Prot

Q3TY26, Q3ULB5

UniProtKB/TrEMBL

B2RWY1

Related

ENSMUSP00000106477.2, ENSMUST00000110853.8

Conserved Domains (2) summary

cd06659
Location:386 → 682

STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6

pfam00786
Location:11 → 63

PBD; P21-Rho-binding domain
NM_001424761.1 → NP_001411690.1 serine/threonine-protein kinase PAK 6

Status: VALIDATED

Source sequence(s)

AL845470

UniProtKB/Swiss-Prot

Q3TY26, Q3ULB5
NM_001424762.1 → NP_001411691.1 serine/threonine-protein kinase PAK 6

Status: VALIDATED

Source sequence(s)

AL845470

UniProtKB/Swiss-Prot

Q3TY26, Q3ULB5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

118493531..118528501

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011239419.1 → XP_011237721.1 serine/threonine-protein kinase PAK 6 isoform X1

See identical proteins and their annotated locations for XP_011237721.1

UniProtKB/Swiss-Prot

Q3TY26, Q3ULB5

UniProtKB/TrEMBL

B2RWY1

Conserved Domains (2) summary

cd06659
Location:386 → 682

STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6

pfam00786
Location:11 → 63

PBD; P21-Rho-binding domain