Fpr2 formyl peptide receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fpr2provided by MGI
Official Full Name: formyl peptide receptor 2provided by MGI
Primary source: MGI:MGI:1278319
See related: Ensembl:ENSMUSG00000052270 AllianceGenome:MGI:1278319
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fpr-rs2; E330010I07Rik
Summary: Enables N-formyl peptide receptor activity and amyloid-beta binding activity. Involved in cellular response to amyloid-beta; positive chemotaxis; and positive regulation of superoxide anion generation. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human FPR2 (formyl peptide receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver E18 (RPKM 10.5), lung adult (RPKM 3.4) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.2; 17 10.66 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (18108086..18114214)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (17887824..17893952)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Formyl peptide receptor 2 regulates dendritic cell metabolism and Th17 cell differentiation during neuroinflammation.
Title: Formyl peptide receptor 2 regulates dendritic cell metabolism and Th17 cell differentiation during neuroinflammation.
The G-Protein-Coupled Formyl Peptide Receptor 2 Promotes Endothelial-Mesenchymal Transition in Diabetic Retinopathy.
Title: The G-Protein-Coupled Formyl Peptide Receptor 2 Promotes Endothelial-Mesenchymal Transition in Diabetic Retinopathy.
Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction.
Title: Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction.
Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFkappaB Activity.
Title: Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFκB Activity.
Transcriptome sequencing and experiments reveal the effect of formyl peptide receptor 2 on liver homeostasis.
Title: Transcriptome sequencing and experiments reveal the effect of formyl peptide receptor 2 on liver homeostasis.
Specialized Pro-resolving Mediator Improves Vascular Relaxation via Formyl Peptide Receptor-2.
Title: Specialized Pro-resolving Mediator Improves Vascular Relaxation via Formyl Peptide Receptor-2.
Keratinocytes use FPR2 to detect Staphylococcus aureus and initiate antimicrobial skin defense.
Title: Keratinocytes use FPR2 to detect Staphylococcus aureus and initiate antimicrobial skin defense.
Resolution of post-lung transplant ischemia-reperfusion injury is modulated via Resolvin D1-FPR2 and Maresin 1-LGR6 signaling.
Title: Resolution of post-lung transplant ischemia-reperfusion injury is modulated via Resolvin D1-FPR2 and Maresin 1-LGR6 signaling.
Developmental and homeostatic signaling transmitted by the G-protein coupled receptor FPR2.
Title: Developmental and homeostatic signaling transmitted by the G-protein coupled receptor FPR2.
Deletion of Annexin A1 in Mice Upregulates the Expression of Its Receptor, Fpr2/3, and Reactivity to the AnxA1 Mimetic Peptide in Platelets.
Title: Deletion of Annexin A1 in Mice Upregulates the Expression of Its Receptor, Fpr2/3, and Reactivity to the AnxA1 Mimetic Peptide in Platelets.

Submit: New GeneRIF Correction See all GeneRIFs (75)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-formyl peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-formyl peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables RAGE receptor binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	IPI Inferred from Physical Interaction more info	PubMed
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables complement receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables scavenger receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amyloid-beta	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in complement receptor mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in immune response-regulating cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: formyl peptide receptor 2

Names: N-formylpeptide receptor-like 2; formyl peptide receptor, related sequence 2; formylpeptide receptor-related sequence 2; lipoxin A4 receptor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.