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    Atp2a3 ATPase, Ca++ transporting, ubiquitous [ Mus musculus (house mouse) ]

    Gene ID: 53313, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Atp2a3provided by MGI
    Official Full Name
    ATPase, Ca++ transporting, ubiquitousprovided by MGI
    Primary source
    MGI:MGI:1194503
    See related
    Ensembl:ENSMUSG00000020788 AllianceGenome:MGI:1194503
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Serca3; SERCA3b
    Summary
    Predicted to enable several functions, including calcium-dependent ATPase activity; cysteine-type endopeptidase activator activity involved in apoptotic process; and transmembrane transporter binding activity. Predicted to be involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; calcium ion transport from cytosol to endoplasmic reticulum; and intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Located in endoplasmic reticulum. Is expressed in diaphragm. Orthologous to human ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 314.1), thymus adult (RPKM 123.3) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp2a3 in Genome Data Viewer
    Location:
    11 B4; 11 45.0 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72851995..72883869)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72961169..72993043)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34704 Neighboring gene predicted gene, 34793 Neighboring gene STARR-positive B cell enhancer ABC_E7013 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72820103-72820212 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 1 Neighboring gene RIKEN cDNA 4732414G09 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72828695-72828896 Neighboring gene STARR-positive B cell enhancer ABC_E10684 Neighboring gene calcium/calmodulin-dependent protein kinase kinase 1, alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NAADP/SERCA3-Dependent Ca(2+) Stores Pathway Specifically Controls Early Autocrine ADP Secretion Potentiating Platelet Activation.
      Title: NAADP/SERCA3-Dependent Ca(2+) Stores Pathway Specifically Controls Early Autocrine ADP Secretion Potentiating Platelet Activation.
    2. SERCA3-dependent Ca(2+) stores control a specific ADP secretion pathway.
      Title: Full activation of mouse platelets requires ADP secretion regulated by SERCA3 ATPase-dependent calcium stores.
    3. ANP counter-regulates cardiac MR activation in hypertensive heart disease. An imbalance in cardiac ANP/GC-A (inhibition) and aldosterone/MR signaling (augmentation) favors adverse cardiac remodeling in chronic pressure overload.
      Title: Atrial natriuretic peptide locally counteracts the deleterious effects of cardiomyocyte mineralocorticoid receptor activation.
    4. This study evaluated the role of SERCA2b and SERCA3 in the control of the free calcium concentration in the endoplasmic reticulum and the role of SERCA3 in the control of insulin secretion.
      Title: Mechanisms of control of the free Ca2+ concentration in the endoplasmic reticulum of mouse pancreatic β-cells: interplay with cell metabolism and [Ca2+]c and role of SERCA2b and SERCA3.
    5. Ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells
      Title: SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells.
    6. identification of promoter region and binding site for Ets-1 in mouse SERCA3
      Title: Basal transcription of the mouse sarco(endo)plasmic reticulum Ca2+-ATPase type 3 gene in endothelial cells is controlled by Ets-1 and Sp1.
    7. regulation in insulin-secreting beta-cells by insulin receptor substrate 1
      Title: Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells.
    8. IRS-1 modulation of insulin secretion is associated with Ca(2+) signaling and expression of SERCA-2b and -3 genes in pancreatic islets. Direct link between insulin resistance and defective insulin secretion.
      Title: Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent ATPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent ATPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type endopeptidase activator activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type endopeptidase activator activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion transport from cytosol to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transport from cytosol to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sarcoplasmic/endoplasmic reticulum calcium ATPase 3
    Names
    SR Ca(2+)-ATPase 3
    calcium pump 3
    sarco /endoplasmic reticulum Ca2+ -ATPase
    sarcoendoplasmic reticulum Ca2+ ATPase type 3
    NP_001156808.1
    NP_001156809.1
    NP_058025.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163336.1 → NP_001156808.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform a

      See identical proteins and their annotated locations for NP_001156808.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AK089487, AK152999, AK155904, BY549777
      Consensus CDS
      CCDS48843.1
      UniProtKB/Swiss-Prot
      O70625, Q64517, Q64518, Q8VD16
      UniProtKB/TrEMBL
      Q3U1K2, Q8R0X5
      Related
      ENSMUSP00000104125.3, ENSMUST00000108485.9
      Conserved Domains (1) summary
      cd02083
      Location:5 → 989
      P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3

    2. NM_001163337.1 → NP_001156809.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an additional exon in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 3 encodes isoform c, which is longer and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK089487, AK152999, AK155904, AL670399, BY549777, U49393
      Consensus CDS
      CCDS48842.1
      UniProtKB/TrEMBL
      E9Q559, Q3U1K2
      Related
      ENSMUSP00000127036.2, ENSMUST00000163326.8
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 989
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:92 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:784 → 987
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:604 → 712
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 528
      Cation_ATPase; Cation transport ATPase (P-type)

    3. NM_016745.3 → NP_058025.2  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform b

      See identical proteins and their annotated locations for NP_058025.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an additional exon in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 2 encodes isoform b, which is longer and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK089487, AK152999, AK155904, BY549777, U49393
      Consensus CDS
      CCDS24991.1
      UniProtKB/TrEMBL
      B1ATS5
      Related
      ENSMUSP00000021142.8, ENSMUST00000021142.8
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 989
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:92 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:784 → 987
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:604 → 712
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 528
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      72851995..72883869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64518.4 GenPept UniProtKB/Swiss-Prot:Q64518

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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