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    Stard8 StAR related lipid transfer domain containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 236920, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Stard8provided by MGI
    Official Full Name
    StAR related lipid transfer domain containing 8provided by MGI
    Primary source
    MGI:MGI:2448556
    See related
    Ensembl:ENSMUSG00000031216 AllianceGenome:MGI:2448556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dlc3; mKIAA0189
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in actin cytoskeleton organization and regulation of Rho protein signal transduction. Predicted to be located in focal adhesion. Orthologous to human STARD8 (StAR related lipid transfer domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 27.0), kidney adult (RPKM 19.8) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stard8 in Genome Data Viewer
    Location:
    X C3; X 43.19 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (98046539..98118334)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (99002933..99074728)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene predicted gene, 52477 Neighboring gene STARR-seq mESC enhancer starr_47608 Neighboring gene STARR-seq mESC enhancer starr_47611 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 57677

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating protein, is downregulated in cancer and inhibits tumor cell growth. Durkin ME, et al. Oncogene, 2007 Jul 5. PMID 17297465
    2. A gene expression resource generated by genome-wide lacZ profiling in the mouse. Tuck E, et al. Dis Model Mech, 2015 Nov. PMID 26398943, Free PMC Article
    3. Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. Boyle MP, et al. J Comp Neurol, 2011 Aug 1. PMID 21491433
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Homology

    Clone Names

    • KIAA0189

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    stAR-related lipid transfer protein 8
    Names
    START domain containing 8
    START domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199018.2 → NP_950183.1  stAR-related lipid transfer protein 8

      See identical proteins and their annotated locations for NP_950183.1

      Status: VALIDATED

      Source sequence(s)
      AK149830, BC062944, BY251063
      Consensus CDS
      CCDS30297.1
      UniProtKB/Swiss-Prot
      B1AZJ2, Q3UZC7, Q6A0A8, Q6P5E0, Q8K031, Q8R3X8
      Related
      ENSMUSP00000044491.8, ENSMUST00000036606.14
      Conserved Domains (2) summary
      cl02570
      Location:565 → 779
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14643
      Location:806 → 1010
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      98046539..98118334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527998.2 → XP_006528061.1  stAR-related lipid transfer protein 8 isoform X1

      Conserved Domains (3) summary
      cd09538
      Location:31 → 90
      SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily
      cl02570
      Location:645 → 859
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14643
      Location:886 → 1090
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    2. XM_036161930.1 → XP_036017823.1  stAR-related lipid transfer protein 8 isoform X5

      UniProtKB/Swiss-Prot
      B1AZJ2, Q3UZC7, Q6A0A8, Q6P5E0, Q8K031, Q8R3X8
      Conserved Domains (2) summary
      cl02570
      Location:565 → 779
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14643
      Location:806 → 1010
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    3. XM_006528002.3 → XP_006528065.1  stAR-related lipid transfer protein 8 isoform X3

      Conserved Domains (2) summary
      cl02570
      Location:572 → 786
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14643
      Location:813 → 1017
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    4. XM_006528005.3 → XP_006528068.1  stAR-related lipid transfer protein 8 isoform X6

      See identical proteins and their annotated locations for XP_006528068.1

      Conserved Domains (2) summary
      cl02570
      Location:552 → 766
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14643
      Location:793 → 997
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    5. XM_030251326.2 → XP_030107186.1  stAR-related lipid transfer protein 8 isoform X5

      UniProtKB/Swiss-Prot
      B1AZJ2, Q3UZC7, Q6A0A8, Q6P5E0, Q8K031, Q8R3X8
      Conserved Domains (2) summary
      cl02570
      Location:565 → 779
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14643
      Location:806 → 1010
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    6. XM_036161931.1 → XP_036017824.1  stAR-related lipid transfer protein 8 isoform X5

      UniProtKB/Swiss-Prot
      B1AZJ2, Q3UZC7, Q6A0A8, Q6P5E0, Q8K031, Q8R3X8
      Conserved Domains (2) summary
      cl02570
      Location:565 → 779
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14643
      Location:806 → 1010
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    7. XM_006528006.3 → XP_006528069.1  stAR-related lipid transfer protein 8 isoform X6

      See identical proteins and their annotated locations for XP_006528069.1

      Conserved Domains (2) summary
      cl02570
      Location:552 → 766
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14643
      Location:793 → 997
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    8. XM_006527999.5 → XP_006528062.1  stAR-related lipid transfer protein 8 isoform X2

      Conserved Domains (3) summary
      cd09538
      Location:27 → 86
      SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily
      cl02570
      Location:641 → 855
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14643
      Location:882 → 1086
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    9. XM_006528003.5 → XP_006528066.1  stAR-related lipid transfer protein 8 isoform X4

      Conserved Domains (2) summary
      cl02570
      Location:571 → 785
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14643
      Location:812 → 1016
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    10. XM_006528007.3 → XP_006528070.1  stAR-related lipid transfer protein 8 isoform X5

      See identical proteins and their annotated locations for XP_006528070.1

      UniProtKB/Swiss-Prot
      B1AZJ2, Q3UZC7, Q6A0A8, Q6P5E0, Q8K031, Q8R3X8
      Conserved Domains (2) summary
      cl02570
      Location:565 → 779
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14643
      Location:806 → 1010
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K031.2 GenPept UniProtKB/Swiss-Prot:Q8K031

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