U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Wnt2b wingless-type MMTV integration site family, member 2B [ Mus musculus (house mouse) ]

    Gene ID: 22414, updated on 5-Nov-2024

    Summary

    Official Symbol
    Wnt2bprovided by MGI
    Official Full Name
    wingless-type MMTV integration site family, member 2Bprovided by MGI
    Primary source
    MGI:MGI:1261834
    See related
    Ensembl:ENSMUSG00000027840 AllianceGenome:MGI:1261834
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wnt13
    Summary
    Predicted to enable cytokine activity and frizzled binding activity. Involved in forebrain regionalization. Acts upstream of or within several processes, including canonical Wnt signaling pathway; mesenchymal-epithelial cell signaling; and regulation of morphogenesis of a branching structure. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; reproductive system; sensory organ; and urethra. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human WNT2B (Wnt family member 2B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in ovary adult (RPKM 10.5), adrenal adult (RPKM 7.2) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Wnt2b in Genome Data Viewer
    Location:
    3 F2.2; 3 45.88 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (104852121..104869025, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (104944805..104961709, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:104667925-104668034 Neighboring gene suppression of tumorigenicity 7-like Neighboring gene ribosomal protein S27 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08625 Neighboring gene predicted gene, 46819 Neighboring gene uncharacterized LOC118568635 Neighboring gene CTTNBP2 N-terminal like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to starvation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in forebrain regionalization IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in hematopoietic stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung induction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mesenchymal-epithelial cell signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of branching involved in ureteric bud morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein Wnt-2b
    Names
    wingless related MMTV integration site 2b
    wnt-13

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009520.3NP_033546.2  protein Wnt-2b

      See identical proteins and their annotated locations for NP_033546.2

      Status: PROVISIONAL

      Source sequence(s)
      AC166156
      Consensus CDS
      CCDS17706.1
      UniProtKB/Swiss-Prot
      O70283, O88530, Q544L3
      Related
      ENSMUSP00000029429.5, ENSMUST00000029429.6
      Conserved Domains (1) summary
      pfam00110
      Location:72378
      wnt; wnt family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      104852121..104869025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)