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    speB agmatinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947715, updated on 19-Sep-2024

    Summary

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    Official Symbol
    speB
    Official Full Name
    agmatinase
    Primary source
    ECOCYC:EG10960
    Locus tag
    b2937
    See related
    ASAP:ABE-0009632
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2932
    Summary
    HT_Cmplx35_Cyt: [More information is available at EcoGene: EG10960]. Agmatinase (SpeB) carries out the second step in putrescine biosynthesis, generating the pathway's putrescine product. [More information is available at EcoCyc: EG10960].
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    Genomic context

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    Sequence:
    NC_000913.3 (3082877..3083797, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene transketolase 1 Neighboring gene metalloprotease LoiP Neighboring gene biosynthetic arginine decarboxylase Neighboring gene acid stress response protein YqgB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a mutant of Escherichia coli blocked in the synthesis of putrescine. Hirshfield IN, et al. J Bacteriol, 1970 Mar. PMID 4908780, Free PMC Article
    2. Antagonistic transcriptional regulation of the putrescine biosynthetic enzyme agmatine ureohydrolase by cyclic AMP and agmatine in Escherichia coli. Satishchandran C, et al. J Bacteriol, 1984 Feb. PMID 6319366, Free PMC Article
    3. Manganese is essential for catalytic activity of Escherichia coli agmatinase. Carvajal N, et al. Biochem Biophys Res Commun, 1999 May 19. PMID 10329468
    4. Evidence that histidine-163 is critical for catalytic activity, but not for substrate binding to Escherichia coli agmatinase. Carvajal N, et al. Biochem Biophys Res Commun, 1999 Oct 14. PMID 10527864
    5. Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling. Salas M, et al. Eur J Biochem, 2002 Nov. PMID 12423350

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure of the E. coli agmatinase, SPEB.
      Title: Structure of the E. coli agmatinase, SPEB.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables agmatinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables agmatinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables agmatinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in putrescine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in putrescine biosynthetic process from arginine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in putrescine biosynthetic process from arginine, using agmatinase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within putrescine biosynthetic process from arginine, using agmatinase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    agmatinase
    NP_417412.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3082877..3083797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417412.1 agmatinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417412.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376UHZ9
      Conserved Domains (1) summary
      PRK02190
      Location:7 → 306
      PRK02190; agmatinase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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