CLEC9A C-type lectin domain containing 9A [Homo sapiens (human)] - Gene

Summary

Official Symbol: CLEC9Aprovided by HGNC
Official Full Name: C-type lectin domain containing 9Aprovided by HGNC
Primary source: HGNC:HGNC:26705
See related: Ensembl:ENSG00000197992 MIM:612252; AllianceGenome:HGNC:26705
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD370; DNGR1; DNGR-1; UNQ9341
Summary: CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008]
Expression: Broad expression in lymph node (RPKM 3.7), spleen (RPKM 2.7) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12p13.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (10030682..10066031)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (9917091..9952444)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (10183281..10218630)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased expression of Clec9A on cDC1s associated with cytotoxic CD8(+) T cell response in COPD.
Title: Increased expression of Clec9A on cDC1s associated with cytotoxic CD8(+) T cell response in COPD.
Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity.
Title: Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity.
Expression of clec9a in the oral cancer microenvironment. A preliminary immunohistochemical pilot study.
Title: Expression of clec9a in the oral cancer microenvironment. A preliminary immunohistochemical pilot study.
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens.
Title: The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens.
Clec9a is responsible for the antigen cross-presentation of dendritic cell subsets and may be a target of immunotherapy
Title: A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy.
findings demonstrate that CLEC9A is a specialized receptor that modulates the innate immune response when there is a mycobacterial infection
Title: CLEC9A modulates macrophage-mediated neutrophil recruitment in response to heat-killed Mycobacterium tuberculosis H37Ra.
Data indicate that blood dendritic cell antigen 3 BDCA3(+) and C-type lectin domain family 9, member A CLEC9A(+) dendritic cells (DC) are of major importance in the induction of anti-viral and anti-tumor immunity.
Title: BDCA3(+)CLEC9A(+) human dendritic cell function and development.
Activated dendritic cell subsets expressing CD141/CLEA9A/CD1c, likely recruited into the tubulointerstitium, are positioned to play a role in the development of fibrosis and, thus, progression to chronic kidney disease.
Title: Increased tubulointerstitial recruitment of human CD141(hi) CLEC9A(+) and CD1c(+) myeloid dendritic cell subsets in renal fibrosis and chronic kidney disease.
study showsn that the DNGR-1 ligand is preserved from yeast to man and corresponds to the F-actin component of the cellular cytoskeleton; identification of F-actin as a DNGR-1 ligand suggests that cytoskeletal exposure is a universal sign of cell damage that can be targeted by the innate immune system to initiate immunity
Title: F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells.
High expression of DNGR-1 specifically and universally identifies a unique dendritic cells subset in mouse and humans.
Title: DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12S1674 (e-PCR), detects polymorphism
- UniSTS:17937

G63920 (e-PCR)
- UniSTS:146466

RH70065 (e-PCR)
- UniSTS:23092

D12S1823 (e-PCR)
- UniSTS:53926

SGC34321 (e-PCR)
- UniSTS:26307

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-type lectin domain family 9 member A

Names: HEEE9341

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207345.4 → NP_997228.1 C-type lectin domain family 9 member A

See identical proteins and their annotated locations for NP_997228.1

Status: VALIDATED

Source sequence(s)

AC024224, AY358265, DB090462, DB526089

Consensus CDS

CCDS8611.1

UniProtKB/Swiss-Prot

B0ZBM2, Q6UXN8

Related

ENSP00000348074.1, ENST00000355819.6

Conserved Domains (1) summary

cd03593
Location:113 → 234

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)