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    ZNF609 zinc finger protein 609 [ Homo sapiens (human) ]

    Gene ID: 23060, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ZNF609provided by HGNC
    Official Full Name
    zinc finger protein 609provided by HGNC
    Primary source
    HGNC:HGNC:29003
    See related
    Ensembl:ENSG00000180357 MIM:617474; AllianceGenome:HGNC:29003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable promoter-specific chromatin binding activity. Involved in regulation of myoblast proliferation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 16.5), ovary (RPKM 10.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF609 in Genome Data Viewer
    Location:
    15q22.31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (64459578..64686068)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (62269004..62495294)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (64752777..64978267)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64673301-64673811 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64679750-64680250 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64680251-64680751 Neighboring gene PCNA clamp associated factor Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:64722213-64722724 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:64722725-64723236 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:64736443-64737642 Neighboring gene uncharacterized LOC105370861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9569 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:64803884-64804071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64820886-64821752 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64831500-64832000 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64832001-64832501 Neighboring gene uncharacterized LOC101930091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9571 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 61 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64849587-64850088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64850089-64850588 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64855291-64855860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64855861-64856430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9572 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9574 Neighboring gene MPRA-validated peak2369 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64895833-64896332 Neighboring gene ribosomal protein S26 pseudogene 50 Neighboring gene NANOG hESC enhancer GRCh37_chr15:64909826-64910418 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9575 Neighboring gene ribosomal protein L21 pseudogene 15 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64945206-64945706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64958513-64959212 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64959213-64959910 Neighboring gene RNA, U6 small nuclear 549, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr15:64977741-64978242 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64991763-64992599 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64992600-64993437 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6537 Neighboring gene uncharacterized LOC124903507 Neighboring gene MPRA-validated peak2370 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65010266-65010766 Neighboring gene ornithine decarboxylase antizyme 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating the AKT/mTOR-autophagy pathway. Ouyang X, et al. Mol Ther, 2023 Jun 7. PMID 36110046, Free PMC Article
    2. CircRNA ZNF609 promotes angiogenesis in nasopharyngeal carcinoma by regulating miR-145/STMN1 axis. Wang J, et al. Kaohsiung J Med Sci, 2021 Aug. PMID 33943007
    3. CircZNF609 inhibits miR-150-5p to promote high glucose-induced damage to retinal microvascular endothelial cells. Gao J, et al. Mol Cell Endocrinol, 2024 Sep 1. PMID 38679361
    4. CircRNA ZNF609 promotes growth and metastasis of nasopharyngeal carcinoma by competing with microRNA-150-5p. Zhu L, et al. Eur Rev Med Pharmacol Sci, 2019 Apr. PMID 31002133
    5. Circ-ZNF609 promotes carcinogenesis of gastric cancer cells by inhibiting miRNA-145-5p expression. Liu Z, et al. Eur Rev Med Pharmacol Sci, 2019 Nov. PMID 31773689

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircZNF609 inhibits miR-150-5p to promote high glucose-induced damage to retinal microvascular endothelial cells.
      Title: CircZNF609 inhibits miR-150-5p to promote high glucose-induced damage to retinal microvascular endothelial cells.
    2. A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating the AKT/mTOR-autophagy pathway.
      Title: A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating the AKT/mTOR-autophagy pathway.
    3. YY1 and eIF4A3 are mediators of the cell proliferation, migration and invasion in cholangiocarcinoma promoted by circ-ZNF609 by targeting miR-432-5p to regulate LRRC1.
      Title: YY1 and eIF4A3 are mediators of the cell proliferation, migration and invasion in cholangiocarcinoma promoted by circ-ZNF609 by targeting miR-432-5p to regulate LRRC1.
    4. CircRNA ZNF609 promotes angiogenesis in nasopharyngeal carcinoma by regulating miR-145/STMN1 axis.
      Title: CircRNA ZNF609 promotes angiogenesis in nasopharyngeal carcinoma by regulating miR-145/STMN1 axis.
    5. Circ-ZNF609 promotes carcinogenesis of gastric cancer cells by inhibiting miRNA-145-5p expression.
      Title: Circ-ZNF609 promotes carcinogenesis of gastric cancer cells by inhibiting miRNA-145-5p expression.
    6. CircRNA ZNF609 promotes growth and metastasis of nasopharyngeal carcinoma by competing with microRNA-150-5p.
      Title: CircRNA ZNF609 promotes growth and metastasis of nasopharyngeal carcinoma by competing with microRNA-150-5p.
    7. our current study reveals the role of the circ-ZNF609/miR-138-5p/FOXP4 regulatory network in renal carcinoma and provides a new perspective for the pathogenesis of renal carcinoma.
      Title: CircRNA ZNF609 functions as a competitive endogenous RNA to regulate FOXP4 expression by sponging miR-138-5p in renal carcinoma.
    8. Circular RNA circ-ZNF609 is associated with heavy polysomes, and it is translated into a protein in a splicing-dependent and cap-independent manner, resulting in a protein that controls myoblast proliferation.
      Title: Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis.
    9. these findings illustrated that cir-ZNF609 took part in the onset of HSCR through the crosstalk with AKT3 by competing for shared miR-150-5p.
      Title: Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0295, MGC164858

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables promoter-specific chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of myoblast proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 609

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015042.2 → NP_055857.1  zinc finger protein 609

      See identical proteins and their annotated locations for NP_055857.1

      Status: VALIDATED

      Source sequence(s)
      AC090543, AC091231
      Consensus CDS
      CCDS32270.1
      UniProtKB/Swiss-Prot
      O15014, Q0D2I2
      Related
      ENSP00000316527.3, ENST00000326648.5
      Conserved Domains (2) summary
      PTZ00121
      Location:1002 → 1200
      PTZ00121; MAEBL; Provisional
      COG5189
      Location:412 → 533
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      64459578..64686068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432263.1 → XP_047288219.1  zinc finger protein 609 isoform X1

      UniProtKB/Swiss-Prot
      O15014, Q0D2I2

    2. XM_047432265.1 → XP_047288221.1  zinc finger protein 609 isoform X1

      UniProtKB/Swiss-Prot
      O15014, Q0D2I2

    3. XM_017022021.2 → XP_016877510.1  zinc finger protein 609 isoform X1

      UniProtKB/Swiss-Prot
      O15014, Q0D2I2
      Conserved Domains (2) summary
      PTZ00121
      Location:1002 → 1200
      PTZ00121; MAEBL; Provisional
      COG5189
      Location:412 → 533
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

    4. XM_047432266.1 → XP_047288222.1  zinc finger protein 609 isoform X1

      UniProtKB/Swiss-Prot
      O15014, Q0D2I2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      62269004..62495294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377549.1 → XP_054233524.1  zinc finger protein 609 isoform X1

      UniProtKB/Swiss-Prot
      O15014, Q0D2I2

    2. XM_054377550.1 → XP_054233525.1  zinc finger protein 609 isoform X1

      UniProtKB/Swiss-Prot
      O15014, Q0D2I2

    3. XM_054377548.1 → XP_054233523.1  zinc finger protein 609 isoform X1

      UniProtKB/Swiss-Prot
      O15014, Q0D2I2

    4. XM_054377551.1 → XP_054233526.1  zinc finger protein 609 isoform X1

      UniProtKB/Swiss-Prot
      O15014, Q0D2I2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15014.2 GenPept UniProtKB/Swiss-Prot:O15014

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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