Dapk1 death associated protein kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dapk1provided by MGI
Official Full Name: death associated protein kinase 1provided by MGI
Primary source: MGI:MGI:1916885
See related: Ensembl:ENSMUSG00000021559 AllianceGenome:MGI:1916885
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D13Ucla1; DAP-Kinase
Summary: Enables ATP binding activity; calmodulin binding activity; and protein kinase activity. Involved in several processes, including cellular response to type II interferon; protein phosphorylation; and regulation of NMDA receptor activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Located in cytoplasm. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; liver and biliary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in urinary bladder cancer and uterine fibroid. Orthologous to human DAPK1 (death associated protein kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 29.9), lung adult (RPKM 28.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B2; 13 32.53 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (60749506..60911005)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (60601723..60763191)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protection of blood-brain barrier by endothelial DAPK1 deletion after stroke.
Title: Protection of blood-brain barrier by endothelial DAPK1 deletion after stroke.
Quantitative Proteomic and Phosphoproteomic Analyses Reveal a Role of Death-Associated Protein Kinase 1 in Regulating Hippocampal Synapse.
Title: Quantitative Proteomic and Phosphoproteomic Analyses Reveal a Role of Death-Associated Protein Kinase 1 in Regulating Hippocampal Synapse.
Ablation of Death-Associated Protein Kinase 1 Changes the Transcriptomic Profile and Alters Neural-Related Pathways in the Brain.
Title: Ablation of Death-Associated Protein Kinase 1 Changes the Transcriptomic Profile and Alters Neural-Related Pathways in the Brain.
DAPK1 Interacts with the p38 Isoform MAPK14, Preventing Its Nuclear Translocation and Stimulation of Bone Marrow Adipogenesis.
Title: DAPK1 Interacts with the p38 Isoform MAPK14, Preventing Its Nuclear Translocation and Stimulation of Bone Marrow Adipogenesis.
MicroRNA-26b-5p Targets DAPK1 to Reduce Intestinal Ischemia/Reperfusion Injury via Inhibition of Intestinal Mucosal Cell Apoptosis.
Title: MicroRNA-26b-5p Targets DAPK1 to Reduce Intestinal Ischemia/Reperfusion Injury via Inhibition of Intestinal Mucosal Cell Apoptosis.
Death-associated protein kinase 1 mediates Abeta42 aggregation-induced neuronal apoptosis and tau dysregulation in Alzheimer's disease.
Title: Death-associated protein kinase 1 mediates Aβ42 aggregation-induced neuronal apoptosis and tau dysregulation in Alzheimer's disease.
Inhibition of Death-associated Protein Kinase 1 protects against Epileptic Seizures in mice.
Title: Inhibition of Death-associated Protein Kinase 1 protects against Epileptic Seizures in mice.
Young DAPK1 knockout mice have altered presynaptic function.
Title: Young DAPK1 knockout mice have altered presynaptic function.
DAPK1 (death associated protein kinase 1) mediates mTORC1 activation and antiviral activities in CD8(+) T cells.
Title: DAPK1 (death associated protein kinase 1) mediates mTORC1 activation and antiviral activities in CD8(+) T cells.
Melatonin directly binds and inhibits death-associated protein kinase 1 function in Alzheimer's disease.
Title: Melatonin directly binds and inhibits death-associated protein kinase 1 function in Alzheimer's disease.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

01.MMHAP62FRA7.seq (e-PCR)
- UniSTS:122663

D13Mit209 (e-PCR), detects polymorphism
- UniSTS:127025

AI642003 (e-PCR)
- UniSTS:164529

Dapk1 (e-PCR), detects polymorphism
- UniSTS:527304

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables calcium/calmodulin-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables calcium/calmodulin-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables syntaxin-1 binding	IEA Inferred from Electronic Annotation more info
enables syntaxin-1 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to hydroperoxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydroperoxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in defense response to tumor cell	IEA Inferred from Electronic Annotation more info
involved_in defense response to tumor cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagic cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of NMDA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of response to tumor cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of DAPK1-calmodulin complex	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: death-associated protein kinase 1

Names: DAP kinase 1

NP_001272846.1

EC 2.7.11.1

NP_083929.2

EC 2.7.11.1

NP_598823.1

EC 2.7.11.1

XP_006517433.1

EC 2.7.11.1

XP_017171087.1

EC 2.7.11.1

XP_030103260.1

EC 2.7.11.1

XP_036014050.1

EC 2.7.11.1

XP_036014051.1

EC 2.7.11.1

XP_036014052.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285917.1 → NP_001272846.1 death-associated protein kinase 1 isoform 2

See identical proteins and their annotated locations for NP_001272846.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC154176, AK145922, BC060161, BQ745486, CT010498, CX244175

Consensus CDS

CCDS88466.1

UniProtKB/Swiss-Prot

Q80YE6, Q80YE7, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7

UniProtKB/TrEMBL

Q3UKP8

Related

ENSMUSP00000153607.2, ENSMUST00000226059.2

Conserved Domains (5) summary

PHA03095
Location:425 → 667

PHA03095; ankyrin-like protein; Provisional

cd08782
Location:1308 → 1393

Death_DAPK1; Death domain found in death-associated protein kinase 1

cd14194
Location:7 → 275

STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1

sd00045
Location:412 → 442

ANK; ANK repeat [structural motif]

pfam13637
Location:379 → 431

Ank_4; Ankyrin repeats (many copies)
NM_029653.3 → NP_083929.2 death-associated protein kinase 1 isoform 1

See identical proteins and their annotated locations for NP_083929.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Both variants 1 and 2 encode the same isoform.

Source sequence(s)

AC154176, AK145922, BC060161, BQ745486, CT010498, CX244175

Consensus CDS

CCDS26581.1

UniProtKB/TrEMBL

Q3UKP8

Related

ENSMUSP00000076666.6, ENSMUST00000077453.13

Conserved Domains (6) summary

PHA03095
Location:425 → 667

PHA03095; ankyrin-like protein; Provisional

cd08782
Location:1308 → 1393

Death_DAPK1; Death domain found in death-associated protein kinase 1

cd14194
Location:7 → 275

STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1

sd00045
Location:412 → 442

ANK; ANK repeat [structural motif]

pfam13637
Location:379 → 431

Ank_4; Ankyrin repeats (many copies)

cl39094
Location:338 → 409

Ank_2; Ankyrin repeats (3 copies)
NM_134062.2 → NP_598823.1 death-associated protein kinase 1 isoform 1

See identical proteins and their annotated locations for NP_598823.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AK145922, BC060161, BQ745486, CT010498

Consensus CDS

CCDS26581.1

UniProtKB/TrEMBL

Q3UKP8

Related

ENSMUSP00000040825.8, ENSMUST00000044083.9

Conserved Domains (6) summary

PHA03095
Location:425 → 667

PHA03095; ankyrin-like protein; Provisional

cd08782
Location:1308 → 1393

Death_DAPK1; Death domain found in death-associated protein kinase 1

cd14194
Location:7 → 275

STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1

sd00045
Location:412 → 442

ANK; ANK repeat [structural motif]

pfam13637
Location:379 → 431

Ank_4; Ankyrin repeats (many copies)

cl39094
Location:338 → 409

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

60749506..60911005

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247400.2 → XP_030103260.1 death-associated protein kinase 1 isoform X4

UniProtKB/Swiss-Prot

Q80YE6, Q80YE7, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7

UniProtKB/TrEMBL

Q3UKP8

Conserved Domains (5) summary

PHA03095
Location:425 → 667

PHA03095; ankyrin-like protein; Provisional

cd08782
Location:1308 → 1393

Death_DAPK1; Death domain found in death-associated protein kinase 1

cd14194
Location:7 → 275

STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1

sd00045
Location:412 → 442

ANK; ANK repeat [structural motif]

pfam13637
Location:379 → 431

Ank_4; Ankyrin repeats (many copies)
XM_036158159.1 → XP_036014052.1 death-associated protein kinase 1 isoform X5

UniProtKB/TrEMBL

Q3UKP8

Conserved Domains (6) summary

PHA03095
Location:425 → 667

PHA03095; ankyrin-like protein; Provisional

cd08782
Location:1308 → 1393

Death_DAPK1; Death domain found in death-associated protein kinase 1

cd14194
Location:7 → 275

STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1

sd00045
Location:412 → 442

ANK; ANK repeat [structural motif]

pfam13637
Location:379 → 431

Ank_4; Ankyrin repeats (many copies)

cl39094
Location:338 → 409

Ank_2; Ankyrin repeats (3 copies)
XM_006517370.5 → XP_006517433.1 death-associated protein kinase 1 isoform X4

See identical proteins and their annotated locations for XP_006517433.1

UniProtKB/Swiss-Prot

Q80YE6, Q80YE7, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7

UniProtKB/TrEMBL

Q3UKP8

Conserved Domains (5) summary

PHA03095
Location:425 → 667

PHA03095; ankyrin-like protein; Provisional

cd08782
Location:1308 → 1393

Death_DAPK1; Death domain found in death-associated protein kinase 1

cd14194
Location:7 → 275

STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1

sd00045
Location:412 → 442

ANK; ANK repeat [structural motif]

pfam13637
Location:379 → 431

Ank_4; Ankyrin repeats (many copies)
XM_017315598.3 → XP_017171087.1 death-associated protein kinase 1 isoform X3

UniProtKB/TrEMBL

Q3UKP8

Conserved Domains (5) summary

PHA03095
Location:406 → 648

PHA03095; ankyrin-like protein; Provisional

cd08782
Location:1289 → 1374

Death_DAPK1; Death domain found in death-associated protein kinase 1

sd00045
Location:393 → 423

ANK; ANK repeat [structural motif]

pfam13637
Location:360 → 412

Ank_4; Ankyrin repeats (many copies)

cl21453
Location:2 → 256

PKc_like; Protein Kinases, catalytic domain
XM_036158158.1 → XP_036014051.1 death-associated protein kinase 1 isoform X2

UniProtKB/TrEMBL

Q3UKP8

Conserved Domains (6) summary

PLN03192
Location:537 → 790

PLN03192; Voltage-dependent potassium channel; Provisional

cd08782
Location:1330 → 1415

Death_DAPK1; Death domain found in death-associated protein kinase 1

sd00045
Location:434 → 464

ANK; ANK repeat [structural motif]

pfam13637
Location:401 → 453

Ank_4; Ankyrin repeats (many copies)

cl21453
Location:35 → 297

PKc_like; Protein Kinases, catalytic domain

cl39094
Location:450 → 661

Ank_2; Ankyrin repeats (3 copies)
XM_036158157.1 → XP_036014050.1 death-associated protein kinase 1 isoform X1

UniProtKB/TrEMBL

Q3UKP8

Conserved Domains (6) summary

PLN03192
Location:537 → 790

PLN03192; Voltage-dependent potassium channel; Provisional

cd08782
Location:1330 → 1415

Death_DAPK1; Death domain found in death-associated protein kinase 1

sd00045
Location:434 → 464

ANK; ANK repeat [structural motif]

pfam13637
Location:401 → 453

Ank_4; Ankyrin repeats (many copies)

cl21453
Location:35 → 297

PKc_like; Protein Kinases, catalytic domain

cl39094
Location:450 → 661

Ank_2; Ankyrin repeats (3 copies)