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    Med13l mediator complex subunit 13-like [ Mus musculus (house mouse) ]

    Gene ID: 76199, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Med13lprovided by MGI
    Official Full Name
    mediator complex subunit 13-likeprovided by MGI
    Primary source
    MGI:MGI:2670178
    See related
    Ensembl:ENSMUSG00000018076 AllianceGenome:MGI:2670178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Thrap2; Trap240L; mKIAA1025; 2210413I17Rik; 6330591G05Rik; 9030618F05Rik
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within transcription by RNA polymerase II. Part of mediator complex. Is expressed in 1-cell stage embryo; 2-cell stage embryo; cortical plate; and primary oocyte. Human ortholog(s) of this gene implicated in dextro-looped transposition of the great arteries. Orthologous to human MED13L (mediator complex subunit 13L). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 10.1), spleen adult (RPKM 6.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Med13l in Genome Data Viewer
    Location:
    5 F; 5 59.1 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (118698363..118903503)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (118560330..118765438)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene basic transcription factor 3, pseudogene 11 Neighboring gene predicted gene, 46921 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:119020268-119020484 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:119040971-119041080 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:119126693-119126894 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:119128855-119129008 Neighboring gene STARR-seq mESC enhancer starr_14210 Neighboring gene predicted gene, 42015 Neighboring gene RIKEN cDNA 4930413E15 gene Neighboring gene STARR-seq mESC enhancer starr_14211

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MED13L and its disease-associated variants influence the dendritic development of cerebral cortical neurons in the mammalian brain. Hamada N, et al. J Neurochem, 2023 May. PMID 36798993
    2. Expression Analyses of Mediator Complex Subunit 13-Like: A Responsible Gene for Neurodevelopmental Disorders during Mouse Brain Development. Hamada N, et al. Dev Neurosci, 2021. PMID 33794529
    3. Analysis of Polymorphisms in the Mediator Complex Subunit 13-like (Med13L) Gene in the Context of Immune Function and Development of Experimental Arthritis. Sardar S, et al. Arch Immunol Ther Exp (Warsz), 2018 Oct. PMID 29951696, Free PMC Article
    4. cDNA cloning and characterization of the human THRAP2 gene which maps to chromosome 12q24, and its mouse ortholog Thrap2. Musante L, et al. Gene, 2004 May 12. PMID 15145061
    5. Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse. Miao YL, et al. Biol Reprod, 2018 Apr 1. PMID 29325037, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MED13L and its disease-associated variants influence the dendritic development of cerebral cortical neurons in the mammalian brain.
      Title: MED13L and its disease-associated variants influence the dendritic development of cerebral cortical neurons in the mammalian brain.
    2. Expression Analyses of Mediator Complex Subunit 13-Like: A Responsible Gene for Neurodevelopmental Disorders during Mouse Brain Development.
      Title: Expression Analyses of Mediator Complex Subunit 13-Like: A Responsible Gene for Neurodevelopmental Disorders during Mouse Brain Development.
    3. this study shows that Med13L polymorphisms between the B10.RIII and RIIIS/J mouse strains do not affect immune phenotype, collagen-induced arthritis development and autoantibody production in these mice
      Title: Analysis of Polymorphisms in the Mediator Complex Subunit 13-like (Med13L) Gene in the Context of Immune Function and Development of Experimental Arthritis.
    4. Transcripts were most abundant in heart.
      Title: cDNA cloning and characterization of the human THRAP2 gene which maps to chromosome 12q24, and its mouse ortholog Thrap2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transcription by RNA polymerase II IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 13-like
    Names
    thyroid hormone receptor associated protein 2
    thyroid hormone receptor-associated protein complex 240 kDa component-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347445.2 → NP_001334374.1  mediator of RNA polymerase II transcription subunit 13-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117585, AC129552
      Consensus CDS
      CCDS84948.1
      UniProtKB/Swiss-Prot
      Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0
      UniProtKB/TrEMBL
      A0A0J9YUA8
      Related
      ENSMUSP00000144092.2, ENSMUST00000201010.2

    2. NM_172424.5 → NP_766012.3  mediator of RNA polymerase II transcription subunit 13-like isoform 2

      See identical proteins and their annotated locations for NP_766012.3

      Status: VALIDATED

      Source sequence(s)
      AC117585, AC129552
      Consensus CDS
      CCDS57375.1
      UniProtKB/Swiss-Prot
      Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0
      UniProtKB/TrEMBL
      E9QLJ3
      Related
      ENSMUSP00000098379.5, ENSMUST00000100816.8
      Conserved Domains (2) summary
      pfam06333
      Location:1675 → 2194
      Med13_C; Mediator complex subunit 13 C-terminal
      pfam11597
      Location:16 → 380
      Med13_N; Mediator complex subunit 13 N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      118698363..118903503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254882.2 → XP_030110742.1  mediator of RNA polymerase II transcription subunit 13-like isoform X2

      UniProtKB/Swiss-Prot
      Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0
      Conserved Domains (3) summary
      pfam06333
      Location:1792 → 2195
      Med13_C; Mediator complex subunit 13 C-terminal
      pfam11597
      Location:11 → 287
      Med13_N; Mediator complex subunit 13 N-terminal
      pfam18296
      Location:1414 → 1756
      MID_MedPIWI; MID domain of medPIWI

    2. XM_011248248.4 → XP_011246550.1  mediator of RNA polymerase II transcription subunit 13-like isoform X1

      UniProtKB/Swiss-Prot
      Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0
      Conserved Domains (3) summary
      pfam06333
      Location:1792 → 2204
      Med13_C; Mediator complex subunit 13 C-terminal
      pfam11597
      Location:11 → 287
      Med13_N; Mediator complex subunit 13 N-terminal
      pfam18296
      Location:1414 → 1756
      MID_MedPIWI; MID domain of medPIWI

    3. XM_036165591.1 → XP_036021484.1  mediator of RNA polymerase II transcription subunit 13-like isoform X3

      UniProtKB/Swiss-Prot
      Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0
      Conserved Domains (2) summary
      pfam06333
      Location:1659 → 2071
      Med13_C; Mediator complex subunit 13 C-terminal
      pfam18296
      Location:1281 → 1623
      MID_MedPIWI; MID domain of medPIWI

    4. XM_030254883.1 → XP_030110743.1  mediator of RNA polymerase II transcription subunit 13-like isoform X3

      UniProtKB/Swiss-Prot
      Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0
      Conserved Domains (2) summary
      pfam06333
      Location:1659 → 2071
      Med13_C; Mediator complex subunit 13 C-terminal
      pfam18296
      Location:1281 → 1623
      MID_MedPIWI; MID domain of medPIWI
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6JPI3.2 GenPept UniProtKB/Swiss-Prot:Q6JPI3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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