Wasf3 WASP family, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wasf3provided by MGI
Official Full Name: WASP family, member 3provided by MGI
Primary source: MGI:MGI:2658986
See related: Ensembl:ENSMUSG00000029636 AllianceGenome:MGI:2658986
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Scar3; Wave3
Summary: Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Involved in modification of postsynaptic actin cytoskeleton. Acts upstream of or within lamellipodium assembly; oligodendrocyte development; and positive regulation of myelination. Located in glial cell projection and lamellipodium. Is active in glutamatergic synapse and postsynapse. Is expressed in adrenal gland; cap mesenchyme; nervous system; and neural retina. Orthologous to human WASF3 (WASP family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 17.1), frontal lobe adult (RPKM 16.1) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G3; 5 85.23 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (146317411..146410425)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (146385006..146473615)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation of the proline-rich domain of WAVE3 drives its oncogenic activity in breast cancer.
Title: Phosphorylation of the proline-rich domain of WAVE3 drives its oncogenic activity in breast cancer.
our work suggests that PCARE is an actin-associated protein that interacts with WASF3 to regulate the actin-driven expansion of the ciliary membrane at the initiation of new outer segment disk formation.
Title: PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation.
Elevated WASF3 Expression Promotes Metastasis in Breast Cancer.
Title: Wasf3 Deficiency Reveals Involvement in Metastasis in a Mouse Model of Breast Cancer.
p63alpha protein up-regulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion
Title: p63α protein up-regulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion.
WAVE3 transcript is mainly expressed in the nervous system and, like all the members of the WASP gene family, WAVE3 is a key element in actin polymerization and cytoskeleton organization.
Title: WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wasf3 (e-PCR), detects polymorphism
- UniSTS:256994

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modification of postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
involved_in modification of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oligodendrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of myelination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in glial cell projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: actin-binding protein WASF3

Names: WAS protein family, member 3; WASP family protein member 3; protein WAVE-3; wiskott-Aldrich syndrome protein family member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418239.1 → NP_001405168.1 actin-binding protein WASF3 isoform a

Status: VALIDATED

Source sequence(s)

AC093356, AC115019

UniProtKB/Swiss-Prot

Q8VHI6
NM_001418240.1 → NP_001405169.1 actin-binding protein WASF3 isoform a

Status: VALIDATED

Source sequence(s)

AC093356, AC115019

UniProtKB/Swiss-Prot

Q8VHI6
NM_001418241.1 → NP_001405170.1 actin-binding protein WASF3 isoform a

Status: VALIDATED

Source sequence(s)

AC093356, AC115019

UniProtKB/Swiss-Prot

Q8VHI6
NM_001418242.1 → NP_001405171.1 actin-binding protein WASF3 isoform b

Status: VALIDATED

Source sequence(s)

AC093356, AC115019
NM_145155.4 → NP_660137.1 actin-binding protein WASF3 isoform a

See identical proteins and their annotated locations for NP_660137.1

Status: VALIDATED

Source sequence(s)

AC093356, AC115019

Consensus CDS

CCDS19870.1

UniProtKB/Swiss-Prot

Q8VHI6

UniProtKB/TrEMBL

Q3V386

Related

ENSMUSP00000016143.8, ENSMUST00000016143.9

Conserved Domains (1) summary

smart00246
Location:439 → 456

WH2; Wiskott Aldrich syndrome homology region 2

RNA

NR_184697.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC093356, AC115019

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

146317411..146410425

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504833.5 → XP_006504896.1 actin-binding protein WASF3 isoform X1

See identical proteins and their annotated locations for XP_006504896.1

UniProtKB/Swiss-Prot

Q8VHI6

UniProtKB/TrEMBL

Q3V386

Conserved Domains (1) summary

smart00246
Location:439 → 456

WH2; Wiskott Aldrich syndrome homology region 2
XM_030254506.2 → XP_030110366.1 actin-binding protein WASF3 isoform X3

Conserved Domains (1) summary

smart00246
Location:227 → 244

WH2; Wiskott Aldrich syndrome homology region 2