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    Madd MAP-kinase activating death domain [ Mus musculus (house mouse) ]

    Gene ID: 228355, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Maddprovided by MGI
    Official Full Name
    MAP-kinase activating death domainprovided by MGI
    Primary source
    MGI:MGI:2444672
    See related
    Ensembl:ENSMUSG00000040687 AllianceGenome:MGI:2444672
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IG20; RabGEF; Rab3GEP; 9630059K23Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in anterograde synaptic vesicle transport; execution phase of apoptosis; and regulation of cell cycle. Acts upstream of or within negative regulation of apoptotic signaling pathway. Predicted to be located in plasma membrane and synaptic vesicle. Predicted to be active in cytosol and synapse. Is expressed in cerebral cortex; nervous system; sensory organ; and tongue. Used to study type 2 diabetes mellitus. Orthologous to human MADD (MAP kinase activating death domain). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 20.7), cortex adult (RPKM 19.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Madd in Genome Data Viewer
    Location:
    2 E1; 2 50.46 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (90967705..91013404, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91137360..91184006, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4476 Neighboring gene Spi-1 proto-oncogene Neighboring gene STARR-positive B cell enhancer ABC_E4477 Neighboring gene STARR-seq mESC enhancer starr_05105 Neighboring gene STARR-seq mESC enhancer starr_05107 Neighboring gene myosin binding protein C, cardiac Neighboring gene STARR-positive B cell enhancer mm9_chr2:91023256-91023557 Neighboring gene STARR-positive B cell enhancer ABC_E4478 Neighboring gene nuclear receptor subfamily 1, group H, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E9070 Neighboring gene predicted gene, 23390 Neighboring gene acid phosphatase 2, lysosomal Neighboring gene damage specific DNA binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses. Yamaguchi K, et al. Proc Natl Acad Sci U S A, 2002 Oct 29. PMID 12388783, Free PMC Article
    2. IG20/MADD plays a critical role in glucose-induced insulin secretion. Li LC, et al. Diabetes, 2014 May. PMID 24379354, Free PMC Article
    3. Accurate phenotypic classification and exome sequencing allow identification of novel genes and variants associated with adult-onset hearing loss. Lewis MA, et al. PLoS Genet, 2023 Nov. PMID 38011198, Free PMC Article
    4. Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle. Lim KM, et al. Int J Cancer, 2004 Mar. PMID 14735464
    5. Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons. Del Villar K, et al. Proc Natl Acad Sci U S A, 2004 Mar 23. PMID 15007167, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings indicated that IG20/MADD plays a critical role in glucose-induced insulin release from beta-cells and that its functional disruption can cause type 2 diabetes.
      Title: IG20/MADD plays a critical role in glucose-induced insulin secretion.
    2. role of Rab3 GEP in regulating neurotransmitter release in autapses of mouse hippocampal neurons in culture
      Title: A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses.
    3. DENN has anti-apoptotic and cell survival roles in tumor cells
      Title: Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterograde synaptic vesicle transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anterograde synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in execution phase of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of pancreatic amylase secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Rab protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MAP kinase-activating death domain protein
    Names
    Rab3 GDP/GTP exchange protein
    Rab3 GEP
    insulinoma-glucagonoma protein 20
    rab3 GDP/GTP exchange factor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177719.1 → NP_001171190.1  MAP kinase-activating death domain protein isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) represents the longest transcript and encodes isoform 10.
      Source sequence(s)
      AK036347, AK122257, BC063386
      Consensus CDS
      CCDS50638.1
      UniProtKB/Swiss-Prot
      Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
      UniProtKB/TrEMBL
      A2AGR0
      Related
      ENSMUSP00000097311.3, ENSMUST00000099723.9
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    2. NM_001177720.1 → NP_001171191.1  MAP kinase-activating death domain protein isoform 11

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) lacks one coding exon, has two additional coding exons, and uses an alternate splice site, compared to variant 10. The resulting isoform (11) is longer and differs at several internal portions and the C-terminus, compared to isoform 10.
      Source sequence(s)
      BC042212, BC063386
      Consensus CDS
      CCDS50635.1
      UniProtKB/TrEMBL
      A2AGQ6, E9QKN1, E9QN47
      Related
      ENSMUSP00000097313.3, ENSMUST00000099725.9
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    3. NM_145527.4 → NP_663502.3  MAP kinase-activating death domain protein isoform 9

      See identical proteins and their annotated locations for NP_663502.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks one exon and uses an alternate splice site in the coding region, compared to variant 10. The resulting isoform (9) differs at two internal portions, compared to isoform 10.
      Source sequence(s)
      AK036347, BC063386
      Consensus CDS
      CCDS38178.1
      UniProtKB/Swiss-Prot
      Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
      UniProtKB/TrEMBL
      A0A0R4J1F4
      Related
      ENSMUSP00000107001.3, ENSMUST00000111370.9
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      90967705..91013404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250251.2 → XP_030106111.1  MAP kinase-activating death domain protein isoform X33

      UniProtKB/TrEMBL
      A2AGQ3
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    2. XM_030250248.2 → XP_030106108.1  MAP kinase-activating death domain protein isoform X31

      UniProtKB/TrEMBL
      A2AGQ3
      Related
      ENSMUSP00000107004.2, ENSMUST00000111373.8
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    3. XM_030250247.2 → XP_030106107.1  MAP kinase-activating death domain protein isoform X30

      UniProtKB/TrEMBL
      A2AGQ3
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    4. XM_036161230.1 → XP_036017123.1  MAP kinase-activating death domain protein isoform X26

      UniProtKB/TrEMBL
      A2AGQ8
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    5. XM_030250245.2 → XP_030106105.1  MAP kinase-activating death domain protein isoform X23

      UniProtKB/TrEMBL
      A2AGQ8
      Related
      ENSMUSP00000107006.2, ENSMUST00000111375.8
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    6. XM_036161217.1 → XP_036017110.1  MAP kinase-activating death domain protein isoform X17

      UniProtKB/TrEMBL
      A2AGQ6
      Related
      ENSMUST00000125321.8
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    7. XM_030250240.2 → XP_030106100.1  MAP kinase-activating death domain protein isoform X16

      UniProtKB/TrEMBL
      A2AGQ7
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    8. XM_030250238.2 → XP_030106098.1  MAP kinase-activating death domain protein isoform X15

      UniProtKB/TrEMBL
      A2AGQ7
      Related
      ENSMUSP00000107003.2, ENSMUST00000111372.8
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    9. XM_036161211.1 → XP_036017104.1  MAP kinase-activating death domain protein isoform X13

      UniProtKB/TrEMBL
      A2AGQ5
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    10. XM_030250227.2 → XP_030106087.1  MAP kinase-activating death domain protein isoform X11

      UniProtKB/TrEMBL
      A2AGQ5
      Related
      ENSMUSP00000107012.3, ENSMUST00000111381.9
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    11. XM_030250208.2 → XP_030106068.1  MAP kinase-activating death domain protein isoform X3

      UniProtKB/TrEMBL
      A2AGQ4
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    12. XM_030250220.2 → XP_030106080.1  MAP kinase-activating death domain protein isoform X8

      UniProtKB/TrEMBL
      A2AGQ5
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    13. XM_030250202.2 → XP_030106062.1  MAP kinase-activating death domain protein isoform X1

      UniProtKB/TrEMBL
      A2AGQ4
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    14. XM_036161224.1 → XP_036017117.1  MAP kinase-activating death domain protein isoform X24

      UniProtKB/Swiss-Prot
      Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    15. XM_036161198.1 → XP_036017091.1  MAP kinase-activating death domain protein isoform X5

      UniProtKB/TrEMBL
      A2AGQ6
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    16. XM_036161257.1 → XP_036017150.1  MAP kinase-activating death domain protein isoform X47

      UniProtKB/TrEMBL
      A2AGR1
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    17. XM_036161255.1 → XP_036017148.1  MAP kinase-activating death domain protein isoform X46

      UniProtKB/TrEMBL
      A2AGR1
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    18. XM_030250257.2 → XP_030106117.1  MAP kinase-activating death domain protein isoform X48

      UniProtKB/TrEMBL
      A2AGR1
      Related
      ENSMUSP00000107000.2, ENSMUST00000111369.8
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    19. XM_036161254.1 → XP_036017147.1  MAP kinase-activating death domain protein isoform X45

      UniProtKB/TrEMBL
      A2AGR1
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    20. XM_036161253.1 → XP_036017146.1  MAP kinase-activating death domain protein isoform X44

      UniProtKB/TrEMBL
      A2AGR1
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    21. XM_036161221.1 → XP_036017114.1  MAP kinase-activating death domain protein isoform X21

      UniProtKB/TrEMBL
      A2AGQ3
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    22. XM_036161250.1 → XP_036017143.1  MAP kinase-activating death domain protein isoform X42

      UniProtKB/TrEMBL
      A2AGR1
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    23. XM_036161218.1 → XP_036017111.1  MAP kinase-activating death domain protein isoform X18

      UniProtKB/TrEMBL
      A2AGQ3
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    24. XM_036161248.1 → XP_036017141.1  MAP kinase-activating death domain protein isoform X41

      UniProtKB/TrEMBL
      A2AGR1
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    25. XM_036161251.1 → XP_036017144.1  MAP kinase-activating death domain protein isoform X43

      UniProtKB/TrEMBL
      A2AGR1
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    26. XM_036161219.1 → XP_036017112.1  MAP kinase-activating death domain protein isoform X19

      UniProtKB/TrEMBL
      A2AGQ8
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    27. XM_030250253.2 → XP_030106113.1  MAP kinase-activating death domain protein isoform X40

      UniProtKB/TrEMBL
      A2AGR1
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    28. XM_036161244.1 → XP_036017137.1  MAP kinase-activating death domain protein isoform X39

      UniProtKB/TrEMBL
      A2AGR1
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    29. XM_036161243.1 → XP_036017136.1  MAP kinase-activating death domain protein isoform X38

      UniProtKB/Swiss-Prot
      Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    30. XM_036161213.1 → XP_036017106.1  MAP kinase-activating death domain protein isoform X14

      UniProtKB/TrEMBL
      A2AGQ8
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    31. XM_036161241.1 → XP_036017134.1  MAP kinase-activating death domain protein isoform X36

      UniProtKB/Swiss-Prot
      Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    32. XM_036161240.1 → XP_036017133.1  MAP kinase-activating death domain protein isoform X35

      UniProtKB/Swiss-Prot
      Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    33. XM_036161239.1 → XP_036017132.1  MAP kinase-activating death domain protein isoform X34

      UniProtKB/Swiss-Prot
      Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    34. XM_030250236.2 → XP_030106096.1  MAP kinase-activating death domain protein isoform X12

      UniProtKB/TrEMBL
      A2AGQ6
      Related
      ENSMUSP00000107007.2, ENSMUST00000111376.8
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    35. XM_036161234.1 → XP_036017127.1  MAP kinase-activating death domain protein isoform X32

      UniProtKB/Swiss-Prot
      Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    36. XM_030250225.2 → XP_030106085.1  MAP kinase-activating death domain protein isoform X10

      UniProtKB/TrEMBL
      A2AGQ6
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    37. XM_036161242.1 → XP_036017135.1  MAP kinase-activating death domain protein isoform X37

      UniProtKB/Swiss-Prot
      Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    38. XM_030250246.2 → XP_030106106.1  MAP kinase-activating death domain protein isoform X29

      UniProtKB/Swiss-Prot
      Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    39. XM_036161202.1 → XP_036017095.1  MAP kinase-activating death domain protein isoform X9

      UniProtKB/TrEMBL
      A2AGQ6
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    40. XM_036161231.1 → XP_036017124.1  MAP kinase-activating death domain protein isoform X27

      UniProtKB/Swiss-Prot
      Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    41. XM_036161199.1 → XP_036017092.1  MAP kinase-activating death domain protein isoform X7

      UniProtKB/TrEMBL
      A2AGQ6
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    42. XM_036161232.1 → XP_036017125.1  MAP kinase-activating death domain protein isoform X28

      UniProtKB/Swiss-Prot
      Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    43. XM_036161228.1 → XP_036017121.1  MAP kinase-activating death domain protein isoform X25

      UniProtKB/Swiss-Prot
      Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    44. XM_030250217.2 → XP_030106077.1  MAP kinase-activating death domain protein isoform X6

      UniProtKB/TrEMBL
      A2AGQ6
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    45. XM_030250244.2 → XP_030106104.1  MAP kinase-activating death domain protein isoform X22

      UniProtKB/Swiss-Prot
      Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    46. XM_030250209.2 → XP_030106069.1  MAP kinase-activating death domain protein isoform X4

      UniProtKB/TrEMBL
      A2AGQ4
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    47. XM_030250242.2 → XP_030106102.1  MAP kinase-activating death domain protein isoform X20

      UniProtKB/Swiss-Prot
      Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    48. XM_030250207.2 → XP_030106067.1  MAP kinase-activating death domain protein isoform X2

      UniProtKB/TrEMBL
      A2AGQ4
      Related
      ENSMUSP00000077094.7, ENSMUST00000077941.13
      Conserved Domains (4) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam15231
      Location:101 → 150
      VCX_VCY; Variable charge X/Y family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001177721.1: Suppressed sequence

      Description
      NM_001177721.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

    2. NM_001177722.1: Suppressed sequence

      Description
      NM_001177722.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

    3. NM_001177723.1: Suppressed sequence

      Description
      NM_001177723.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

    4. NM_001177724.1: Suppressed sequence

      Description
      NM_001177724.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

    5. NM_001177725.1: Suppressed sequence

      Description
      NM_001177725.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

    6. NM_001177726.1: Suppressed sequence

      Description
      NM_001177726.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

    7. NM_001177727.1: Suppressed sequence

      Description
      NM_001177727.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

    8. NM_001177728.1: Suppressed sequence

      Description
      NM_001177728.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

    9. NM_001177729.1: Suppressed sequence

      Description
      NM_001177729.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

    10. NM_178369.1: Suppressed sequence

      Description
      NM_178369.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80U28.2 GenPept UniProtKB/Swiss-Prot:Q80U28

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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