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    LPAR3 lysophosphatidic acid receptor 3 [ Homo sapiens (human) ]

    Gene ID: 23566, updated on 17-Jun-2024

    Summary

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    Official Symbol
    LPAR3provided by HGNC
    Official Full Name
    lysophosphatidic acid receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:14298
    See related
    Ensembl:ENSG00000171517 MIM:605106; AllianceGenome:HGNC:14298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EDG7; GPCR; LPA3; Edg-7; LP-A3; HOFNH30; RP4-678I3
    Summary
    This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in prostate (RPKM 8.7), testis (RPKM 8.1) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LPAR3 in Genome Data Viewer
    Location:
    1p22.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (84811602..84893206, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (84652193..84733814, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (85277285..85358889, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SSX family member 2 interacting protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1024 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1025 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:85222320-85222891 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:85240543-85241042 Neighboring gene uncharacterized LOC102724892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1259 Neighboring gene Sharpr-MPRA regulatory region 13288 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1260 Neighboring gene mucolipin TRP cation channel 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1027 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:85463659-85464530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1265 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1029 Neighboring gene mucolipin TRP cation channel 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3. Yang S, et al. Oncotarget, 2015 Nov 3. PMID 26440309, Free PMC Article
    2. Aberrant expression and potential therapeutic target of lysophosphatidic acid receptor 3 in triple-negative breast cancers. Sun K, et al. Clin Exp Med, 2015 Aug. PMID 25209561, Free PMC Article
    3. Loss of lysophosphatidic acid receptor-3 suppresses cell migration activity of human sarcoma cells. Tanabe E, et al. J Recept Signal Transduct Res, 2012 Dec. PMID 23167620
    4. Cyclic regulation of LPA3 in human endometrium. Guo H, et al. Arch Gynecol Obstet, 2013 Jan. PMID 22872026
    5. Negative regulation of cell motile and invasive activities by lysophosphatidic acid receptor-3 in colon cancer HCT116 cells. Fukui R, et al. Tumour Biol, 2012 Dec. PMID 22763559

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LPAR1 and aberrantly expressed LPAR3 differentially promote the migration and proliferation of malignant peripheral nerve sheath tumor cells.
      Title: LPAR1 and aberrantly expressed LPAR3 differentially promote the migration and proliferation of malignant peripheral nerve sheath tumor cells.
    2. The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages.
      Title: The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages.
    3. Effects of lysophosphatidic acid (LPA) receptor-2 (LPA2) and LPA3 on the regulation of chemoresistance to anticancer drug in lung cancer cells.
      Title: Effects of lysophosphatidic acid (LPA) receptor-2 (LPA(2)) and LPA(3) on the regulation of chemoresistance to anticancer drug in lung cancer cells.
    4. Transcriptional regulation of lysophosphatidic acid receptors 2 and 3 regulates myeloid commitment of hematopoietic stem cells.
      Title: Transcriptional regulation of lysophosphatidic acid receptors 2 and 3 regulates myeloid commitment of hematopoietic stem cells.
    5. Roles of endothelial cells in the regulation of cell motility via lysophosphatidic acid receptor-2 (LPA2) and LPA3 in osteosarcoma cells.
      Title: Roles of endothelial cells in the regulation of cell motility via lysophosphatidic acid receptor-2 (LPA(2)) and LPA(3) in osteosarcoma cells.
    6. Lysophosphatidic acid receptor LPA3 prevents oxidative stress and cellular senescence in Hutchinson-Gilford progeria syndrome.
      Title: Lysophosphatidic acid receptor LPA(3) prevents oxidative stress and cellular senescence in Hutchinson-Gilford progeria syndrome.
    7. Study also identifies that LPAR3 increases miR-122-5p expression, which occurs mechanistically through the SH3 domain and helps explain why miR-122-5p increases are detected in cancer patient serum. LPAR3 is partially responsible for the production and secretion of miR-122-5p, found in the serum of a wide variety of patients with cancer.
      Title: miR-122-5p Expression and Secretion in Melanoma Cells Is Amplified by the LPAR3 SH3-Binding Domain to Regulate Wnt1.
    8. LPAR3 was differently expressed in melanosis coli tissues.LPAR3 expression was related to cell apoptosis.
      Title: Identification of candidate biomarkers associated with apoptosis in melanosis coli: GNG5, LPAR3, MAPK8, and PSMC6.
    9. Using pharmacological activators and shRNA knockdown experiments, we demonstrate that activation of LPA3 inhibits megakaryopoiesis in human HSCs. In addition, pharmacological activation of LPA3 suppressed thrombopoiesis in zebrafish.
      Title: Activation of Lysophosphatidic Acid Receptor 3 Inhibits Megakaryopoiesis in Human Hematopoietic Stem Cells and Zebrafish.
    10. The results indicate that LPA2 and LPA3 receptors play opposing roles during red blood cells differentiation.
      Title: Pharmacological activation of lysophosphatidic acid receptors regulates erythropoiesis.
    Submit: New GeneRIF Correction See all GeneRIFs (38)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.
    EBI GWAS Catalog
    Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
    EBI GWAS Catalog
    Genome-wide association study of smoking behaviours among Bangladeshi adults.
    EBI GWAS Catalog
    GWAS of dental caries patterns in the permanent dentition.
    EBI GWAS Catalog
    The genetic architecture of economic and political preferences.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of lysophosphatidic acid receptor 3 (LPAR3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ98231

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables lysophosphatidic acid receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bleb assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in collateral sprouting IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of collateral sprouting IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysophosphatidic acid receptor 3
    Names
    LPA receptor 3
    LPA receptor EDG7
    LPA-3
    calcium-mobilizing lysophosphatidic acid receptor LP-A3
    endothelial cell differentiation gene 7
    endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7
    lysophosphatidic acid receptor Edg-7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012152.3 → NP_036284.1  lysophosphatidic acid receptor 3

      See identical proteins and their annotated locations for NP_036284.1

      Status: REVIEWED

      Source sequence(s)
      AC104169, AK308283, BC126268, BU633960
      Consensus CDS
      CCDS700.1
      UniProtKB/Swiss-Prot
      A0AVA3, Q9UBY5
      UniProtKB/TrEMBL
      Q9NRB8
      Related
      ENSP00000359643.3, ENST00000370611.4
      Conserved Domains (1) summary
      cd15343
      Location:31 → 304
      7tmA_LPAR3_Edg7; lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      84811602..84893206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      84652193..84733814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335709.1 → XP_054191684.1  lysophosphatidic acid receptor 3 isoform X1

      UniProtKB/TrEMBL
      Q9NRB8

    2. XM_054335710.1 → XP_054191685.1  lysophosphatidic acid receptor 3 isoform X2

      UniProtKB/Swiss-Prot
      A0AVA3, Q9UBY5
      UniProtKB/TrEMBL
      Q9NRB8

    3. XM_054335711.1 → XP_054191686.1  lysophosphatidic acid receptor 3 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UBY5.1 GenPept UniProtKB/Swiss-Prot:Q9UBY5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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