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    TXLNB taxilin beta [ Homo sapiens (human) ]

    Gene ID: 167838, updated on 3-Nov-2024

    Summary

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    Official Symbol
    TXLNBprovided by HGNC
    Official Full Name
    taxilin betaprovided by HGNC
    Primary source
    HGNC:HGNC:21617
    See related
    Ensembl:ENSG00000164440 MIM:611438; AllianceGenome:HGNC:21617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MDP77; LST001; C6orf198; dJ522B19.2
    Summary
    Predicted to enable syntaxin binding activity. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart (RPKM 26.4), ovary (RPKM 5.2) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TXLNB in Genome Data Viewer
    Location:
    6q24.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (139159162..139323950, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (140347705..140507844, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (139561198..139613135, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene epithelial cell transforming 2 like Neighboring gene RALBP1 associated Eps domain containing 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:139298793-139299367 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17602 Neighboring gene NANOG hESC enhancer GRCh37_chr6:139331747-139332499 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17603 Neighboring gene Sharpr-MPRA regulatory region 12009 Neighboring gene ABRA C-terminal like Neighboring gene Sharpr-MPRA regulatory region 5517 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:139447769-139448270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25165 Neighboring gene Sharpr-MPRA regulatory region 4168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25166 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:139484703-139485202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25168 Neighboring gene hdc homolog, cell cycle regulator Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:139563281-139563806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:139563807-139564332 Neighboring gene Sharpr-MPRA regulatory region 11439 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:139583345-139584544 Neighboring gene uncharacterized LOC102723690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25169 Neighboring gene Sharpr-MPRA regulatory region 14530 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:139634569-139635306 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:139635307-139636044 Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:139689956-139690774 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17611 Neighboring gene Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Muscle-specific protein MDP77 specifically promotes motor nerve regeneration in rats. Itoh S, et al. Neurosci Lett, 2004 Apr 29. PMID 15082161
    2. Regulatory expression of MDP77 protein in the skeletal and cardiac muscles. Fujimori KE, et al. FEBS Lett, 2002 Oct 9. PMID 12372618
    3. Identification and characterization of taxilin isoforms. Nogami S, et al. Biochem Biophys Res Commun, 2004 Jul 2. PMID 15184072
    4. CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Kim DY, et al. Mol Cell, 2013 Feb 21. PMID 23333304, Free PMC Article
    5. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Li S, et al. Immunity, 2011 Sep 23. PMID 21903422, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. identification of isoforms of taxilin; interaction with syntaxin; tissue distribution [beta-taxilin, gamma-taxilin].
      Title: Identification and characterization of taxilin isoforms.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of taxilin beta (TXLNB) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp451A175

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    beta-taxilin
    Names
    muscle-derived protein 77

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153235.4 → NP_694967.3  beta-taxilin

      See identical proteins and their annotated locations for NP_694967.3

      Status: VALIDATED

      Source sequence(s)
      AB085905, AL158850
      Consensus CDS
      CCDS34545.1
      UniProtKB/Swiss-Prot
      Q5HYH7, Q5VTF3, Q76L25, Q86T52, Q8N3L3, Q8N3S2
      UniProtKB/TrEMBL
      B2RBM1, Q5HYK6
      Related
      ENSP00000351206.3, ENST00000358430.8
      Conserved Domains (2) summary
      pfam09728
      Location:143 → 450
      Taxilin; Myosin-like coiled-coil protein
      cl26386
      Location:519 → 683
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      139159162..139323950 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005266836.2 → XP_005266893.1  beta-taxilin isoform X1

      See identical proteins and their annotated locations for XP_005266893.1

      UniProtKB/Swiss-Prot
      Q5HYH7, Q5VTF3, Q76L25, Q86T52, Q8N3L3, Q8N3S2
      UniProtKB/TrEMBL
      B2RBM1, Q5HYK6
      Conserved Domains (2) summary
      pfam09728
      Location:143 → 450
      Taxilin; Myosin-like coiled-coil protein
      cl26386
      Location:519 → 683
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    2. XM_047418253.1 → XP_047274209.1  beta-taxilin isoform X1

      UniProtKB/Swiss-Prot
      Q5HYH7, Q5VTF3, Q76L25, Q86T52, Q8N3L3, Q8N3S2

    3. XM_024446341.2 → XP_024302109.1  beta-taxilin isoform X1

      UniProtKB/Swiss-Prot
      Q5HYH7, Q5VTF3, Q76L25, Q86T52, Q8N3L3, Q8N3S2
      UniProtKB/TrEMBL
      B2RBM1, Q5HYK6
      Conserved Domains (2) summary
      pfam09728
      Location:143 → 450
      Taxilin; Myosin-like coiled-coil protein
      cl26386
      Location:519 → 683
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    4. XM_047418252.1 → XP_047274208.1  beta-taxilin isoform X1

      UniProtKB/Swiss-Prot
      Q5HYH7, Q5VTF3, Q76L25, Q86T52, Q8N3L3, Q8N3S2

    5. XM_011535506.3 → XP_011533808.1  beta-taxilin isoform X2

      See identical proteins and their annotated locations for XP_011533808.1

      Conserved Domains (2) summary
      pfam09728
      Location:1 → 303
      Taxilin; Myosin-like coiled-coil protein
      cl19219
      Location:129 → 204
      DUF342; Protein of unknown function (DUF342)

    RNA

    1. XR_007059217.1 RNA Sequence

    2. XR_007059220.1 RNA Sequence

    3. XR_007059216.1 RNA Sequence

    4. XR_007059219.1 RNA Sequence

    5. XR_007059218.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      140347705..140507844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354389.1 → XP_054210364.1  beta-taxilin isoform X1

    2. XM_054354390.1 → XP_054210365.1  beta-taxilin isoform X1

    3. XM_054354391.1 → XP_054210366.1  beta-taxilin isoform X2

    RNA

    1. XR_008487268.1 RNA Sequence

    2. XR_008487271.1 RNA Sequence

    3. XR_008487267.1 RNA Sequence

    4. XR_008487270.1 RNA Sequence

    5. XR_008487269.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N3L3.3 GenPept UniProtKB/Swiss-Prot:Q8N3L3

    Gene LinkOut

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