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    C11orf42 chromosome 11 open reading frame 42 [ Homo sapiens (human) ]

    Gene ID: 160298, updated on 17-Sep-2024

    Summary

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    Official Symbol
    C11orf42provided by HGNC
    Official Full Name
    chromosome 11 open reading frame 42provided by HGNC
    Primary source
    HGNC:HGNC:28541
    See related
    Ensembl:ENSG00000180878 AllianceGenome:HGNC:28541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in testis (RPKM 2.0), skin (RPKM 0.8) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See C11orf42 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6205557..6211135)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6264010..6269583)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6226787..6232365)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily B member 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6206230-6206930 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6206931-6207629 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:6220268-6220768 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:6220769-6221269 Neighboring gene MPRA-validated peak1185 silencer Neighboring gene olfactory receptor family 52 subfamily W member 1 Neighboring gene FHF complex subunit HOOK interacting protein 1B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3097 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3098 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6256113-6256803 Neighboring gene cyclic nucleotide gated channel subunit alpha 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article
    2. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
    3. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC34805

    General protein information

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    Preferred Names
    uncharacterized protein C11orf42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173525.3 → NP_775796.2  uncharacterized protein C11orf42

      See identical proteins and their annotated locations for NP_775796.2

      Status: VALIDATED

      Source sequence(s)
      AA781757, AC022762, BC031612
      Consensus CDS
      CCDS7759.1
      UniProtKB/Swiss-Prot
      Q8N5U0
      Related
      ENSP00000321021.2, ENST00000316375.3
      Conserved Domains (1) summary
      pfam15668
      Location:1 → 328
      DUF4663; Domain of unknown function (DUF4663)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      6205557..6211135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      6264010..6269583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N5U0.2 GenPept UniProtKB/Swiss-Prot:Q8N5U0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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