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    TRIM22 tripartite motif containing 22 [ Homo sapiens (human) ]

    Gene ID: 10346, updated on 14-Nov-2024

    Summary

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    Official Symbol
    TRIM22provided by HGNC
    Official Full Name
    tripartite motif containing 22provided by HGNC
    Primary source
    HGNC:HGNC:16379
    See related
    Ensembl:ENSG00000132274 MIM:606559; AllianceGenome:HGNC:16379
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF94; STAF50; GPSTAF50
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein is involved in innate immunity against different DNA and RNA viruses. [provided by RefSeq, Oct 2021]
    Expression
    Broad expression in spleen (RPKM 83.9), lymph node (RPKM 70.5) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See TRIM22 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (5689790..5710863)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (5747640..5768714)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (5711020..5732093)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene TRIM6-TRIM34 readthrough Neighboring gene tripartite motif containing 5 Neighboring gene NANOG hESC enhancer GRCh37_chr11:5642663-5643271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4327 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4330 Neighboring gene tripartite motif containing 34 Neighboring gene uncharacterized LOC107984302 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:5700031-5701230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4331 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:5711125-5712324 Neighboring gene uncharacterized LOC124902620 Neighboring gene olfactory receptor family 52 subfamily U member 1 pseudogene Neighboring gene olfactory receptor family 52 subfamily N member 4 Neighboring gene olfactory receptor family 52 subfamily P member 1 (gene/pseudogene)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Ancient and recent adaptive evolution in the antiviral TRIM22 gene: identification of a single-nucleotide polymorphism that impacts TRIM22 function. Kelly JN, et al. Hum Mutat, 2014 Sep. PMID 24863734
    2. TRIM22 regulates macrophage autophagy and enhances Mycobacterium tuberculosis clearance by targeting the nuclear factor-multiplicity κB/beclin 1 pathway. Lou J, et al. J Cell Biochem, 2018 Nov. PMID 30011088
    3. TRIM22 knockdown suppresses chronic myeloid leukemia via inhibiting PI3K/Akt/mTOR signaling pathway. Li L, et al. Cell Biol Int, 2018 Sep. PMID 29762880
    4. The interferon-stimulated gene TRIM22: A double-edged sword in HIV-1 infection. Vicenzi E, et al. Cytokine Growth Factor Rev, 2018 Apr. PMID 29650252
    5. Interferons command Trim22 to fight against viruses. Lian Q, et al. Cell Mol Immunol, 2017 Sep. PMID 28782753, Free PMC Article

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The E3 ligase TRIM22 functions as a tumor suppressor in breast cancer by targeting CCS for proteasomal degradation to inhibit STAT3 signaling.
      Title: The E3 ligase TRIM22 functions as a tumor suppressor in breast cancer by targeting CCS for proteasomal degradation to inhibit STAT3 signaling.
    2. The E3 ligase TRIM22 restricts SARS-CoV-2 replication by promoting proteasomal degradation of NSP8.
      Title: The E3 ligase TRIM22 restricts SARS-CoV-2 replication by promoting proteasomal degradation of NSP8.
    3. TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma.
      Title: TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma.
    4. TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1.
      Title: TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1.
    5. TRIM22 actives PI3K/Akt/mTOR pathway to promote psoriasis through enhancing cell proliferation and inflammation and inhibiting autophagy.
      Title: TRIM22 actives PI3K/Akt/mTOR pathway to promote psoriasis through enhancing cell proliferation and inflammation and inhibiting autophagy.
    6. On the relationship between tripartite motif-containing 22 single-nucleotide polymorphisms and COVID-19 infection severity.
      Title: On the relationship between tripartite motif-containing 22 single-nucleotide polymorphisms and COVID-19 infection severity.
    7. FOXC1mediated TRIM22 regulates the excessive proliferation and inflammation of fibroblastlike synoviocytes in rheumatoid arthritis via NFkappaB signaling pathway.
      Title: FOXC1‑mediated TRIM22 regulates the excessive proliferation and inflammation of fibroblast‑like synoviocytes in rheumatoid arthritis via NF‑κB signaling pathway.
    8. Role of TRIM22 in ulcerative colitis and its underlying mechanisms.
      Title: Role of TRIM22 in ulcerative colitis and its underlying mechanisms.
    9. TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling.
      Title: TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling.
    10. TRIM22 genotype is not associated with markers of disease progression in children with HIV-1 infection.
      Title: TRIM22 genotype is not associated with markers of disease progression in children with HIV-1 infection.
    Submit: New GeneRIF Correction See all GeneRIFs (61)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of tripartite motif containing 22 (TRIM22) in human B cells PubMed
    env HIV-1 gp120-treated vaginal epithelial cells show upregulation of tripartite motif containing 22 (TRIM22) expression as compared to untreated control PubMed
    Pr55(Gag) gag TRIM22 changes the sub-cellular localization of Gag protein. The catalytic cysteine residues C15 and C18 are important for the antiviral effects of TRIM22 PubMed
    gag IFN-beta-induced expression of TRIM22 restricts HIV-1 replication. TRIM22 inhibits the budding of HIV-1 Gag-only particles PubMed
    gag A direct or indirect interaction of TRIM21 with HIV-1 Gag induces encapsidation of TRIM21 into virus particles, leading to slightly reduced virus titers PubMed
    Tat tat HIV-1 and the viral protein Tat modulate the expression of tripartite motif-containing 22 (TRIM22; STAF50) in immature dendritic cells and monocyte-derived macrophages PubMed
    tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Staf50, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
    tat Staf-50 downregulates transcription directed by the HIV-1 LTR promoter, suggesting an inhibition of HIV-1 Tat function PubMed
    tat Overexpression of Staf50, which is known to repress the activity of HIV-1 Tat, inhibits HIV-1 infection between 50% and 90% in 293 T CD4/CCR5 cells as well as in monocyte-derived macrophages (MAC) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: OR56B1

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of defense response to virus by host IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to virus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Cajal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM22
    Names
    50 kDa-stimulated trans-acting factor
    RING finger protein 94
    RING-type E3 ubiquitin transferase TRIM22
    staf-50
    stimulated trans-acting factor (50 kDa)
    tripartite binding motif 22
    tripartite motif protein TRIM22
    tripartite motif-containing protein 22
    NP_001186502.1
    NP_006065.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199573.2 → NP_001186502.1  E3 ubiquitin-protein ligase TRIM22 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AL360190, BC022281, BC035582, DC364428, X82200
      UniProtKB/TrEMBL
      A0A348GSH8
      Conserved Domains (4) summary
      smart00336
      Location:92 → 133
      BBOX; B-Box-type zinc finger
      pfam14942
      Location:133 → 203
      Muted; Organelle biogenesis, Muted-like protein
      cd15824
      Location:295 → 492
      SPRY_PRY_TRIM22; PRY/SPRY domain in tripartite motif-containing protein 22 (TRIM22), also known as RING finger protein 94 (RNF94) or Stimulated trans-acting factor of 50 kDa (STAF50)
      cl17238
      Location:15 → 59
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_006074.5 → NP_006065.2  E3 ubiquitin-protein ligase TRIM22 isoform 1

      See identical proteins and their annotated locations for NP_006065.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL360190, BC022281, BC035582, DC364428
      Consensus CDS
      CCDS41612.1
      UniProtKB/Swiss-Prot
      Q05CQ0, Q15521, Q8IYM9
      UniProtKB/TrEMBL
      D3DQT0
      Related
      ENSP00000369299.3, ENST00000379965.8
      Conserved Domains (4) summary
      smart00336
      Location:92 → 133
      BBOX; B-Box-type zinc finger
      pfam15035
      Location:129 → 205
      Rootletin; Ciliary rootlet component, centrosome cohesion
      cd15824
      Location:299 → 496
      SPRY_PRY_TRIM22; PRY/SPRY domain in tripartite motif-containing protein 22 (TRIM22), also known as RING finger protein 94 (RNF94) or Stimulated trans-acting factor of 50 kDa (STAF50)
      cl17238
      Location:15 → 59
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      5689790..5710863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      5747640..5768714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IYM9.1 GenPept UniProtKB/Swiss-Prot:Q8IYM9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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