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    AMZ2 archaelysin family metallopeptidase 2 [ Homo sapiens (human) ]

    Gene ID: 51321, updated on 3-Nov-2024

    Summary

    Official Symbol
    AMZ2provided by HGNC
    Official Full Name
    archaelysin family metallopeptidase 2provided by HGNC
    Primary source
    HGNC:HGNC:28041
    See related
    Ensembl:ENSG00000196704 MIM:615169; AllianceGenome:HGNC:28041
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a zinc metalloprotease that displays some activity against angiotensin-3. The encoded protein is inhibited by the aminopeptidase inhibitor amastatin, as well as by the general inhibitors o-phenanthroline and batimastat. Defects in this gene may be associated with lung tumorigenesis. [provided by RefSeq, Oct 2016]
    Expression
    Broad expression in testis (RPKM 44.9), brain (RPKM 18.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See AMZ2 in Genome Data Viewer
    Location:
    17q24.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (68206129..68257164)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (69082913..69133740)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (66202270..66253305)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66165711-66166210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66180501-66181101 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12640 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12641 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66196439-66197255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8893 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8895 Neighboring gene Rho GTPase activating protein 27 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66224773-66225658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66242704-66243250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66243251-66243796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8897 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8898 Neighboring gene solute carrier family 16 member 6 Neighboring gene arylsulfatase G Neighboring gene ReSE screen-validated silencer GRCh37_chr17:66287460-66287634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12644 Neighboring gene Sharpr-MPRA regulatory region 10227 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:66340482-66340982 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:66340983-66341483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12646 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12647 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66374359-66374878 Neighboring gene MPRA-validated peak2959 silencer Neighboring gene tRNA-undetermined (NNN) 5-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    archaemetzincin-2
    Names
    archaemetzincins-2
    archeobacterial metalloproteinase-like protein 2
    NP_001028741.1
    NP_001028742.1
    NP_001028743.1
    NP_001028744.1
    NP_001028746.1
    NP_001275983.1
    NP_001275985.1
    NP_001333400.1
    NP_001333401.1
    NP_001333402.1
    NP_001333403.1
    NP_001333404.1
    NP_001333405.1
    NP_001333406.1
    NP_001333407.1
    NP_001333408.1
    NP_001333409.1
    NP_001333410.1
    NP_001333411.1
    NP_001333412.1
    NP_001333413.1
    NP_001333414.1
    NP_057711.3
    XP_024306554.1
    XP_024306555.1
    XP_024306556.1
    XP_047292166.1
    XP_047292167.1
    XP_054172343.1
    XP_054172344.1
    XP_054172345.1
    XP_054172346.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051827.1 RefSeqGene

      Range
      46915..56027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001033569.2NP_001028741.1  archaemetzincin-2 isoform 1

      See identical proteins and their annotated locations for NP_001028741.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 and 7-17 all encode the same isoform (1).
      Source sequence(s)
      AC005332, BE543044, BF978559
      Consensus CDS
      CCDS11674.1
      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Related
      ENSP00000376481.2, ENST00000392720.6
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    2. NM_001033570.2NP_001028742.1  archaemetzincin-2 isoform 1

      See identical proteins and their annotated locations for NP_001028742.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 and 7-17 all encode the same isoform (1).
      Source sequence(s)
      AC005332, BE543044, CN278872
      Consensus CDS
      CCDS11674.1
      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    3. NM_001033571.1NP_001028743.1  archaemetzincin-2 isoform 1

      See identical proteins and their annotated locations for NP_001028743.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 and 7-17 all encode the same isoform (1).
      Source sequence(s)
      AC005332, BE543044, BF978559, BM450564
      Consensus CDS
      CCDS11674.1
      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    4. NM_001033572.1NP_001028744.1  archaemetzincin-2 isoform 1

      See identical proteins and their annotated locations for NP_001028744.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 and 7-17 all encode the same isoform (1).
      Source sequence(s)
      AC005332, BE543044, BF978559
      Consensus CDS
      CCDS11674.1
      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Related
      ENSP00000463012.1, ENST00000580753.5
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    5. NM_001033574.2NP_001028746.1  archaemetzincin-2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 18 both encode the same isoform (2).
      Source sequence(s)
      AC005332, AK126146, AW028610
      Consensus CDS
      CCDS32714.1
      UniProtKB/Swiss-Prot
      Q86W34
      Related
      ENSP00000352831.4, ENST00000359783.8
      Conserved Domains (1) summary
      cd11375
      Location:95239
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    6. NM_001289054.2NP_001275983.1  archaemetzincin-2 isoform 1

      See identical proteins and their annotated locations for NP_001275983.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-5 and 7-17 all encode the same isoform (1).
      Source sequence(s)
      AC005332, BC050709
      Consensus CDS
      CCDS11674.1
      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    7. NM_001289056.2NP_001275985.1  archaemetzincin-2 isoform 1

      See identical proteins and their annotated locations for NP_001275985.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-5 and 7-17 all encode the same isoform (1).
      Source sequence(s)
      AC005332, AF208856, BC050709, CN278874
      Consensus CDS
      CCDS11674.1
      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Related
      ENSP00000483162.1, ENST00000612294.4
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    8. NM_001346471.1NP_001333400.1  archaemetzincin-2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 1-5, 7-8, and 10-17, encodes isoform 1.
      Source sequence(s)
      AC005332
      Consensus CDS
      CCDS11674.1
      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Related
      ENSP00000464635.1, ENST00000577985.5
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    9. NM_001346472.1NP_001333401.1  archaemetzincin-2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 1-5, 7-9, and 11-17, encodes isoform 1.
      Source sequence(s)
      AC005332
      Consensus CDS
      CCDS11674.1
      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    10. NM_001346473.1NP_001333402.1  archaemetzincin-2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 1-5, 7-10, and 12-17, encodes isoform 1.
      Source sequence(s)
      AC005332
      Consensus CDS
      CCDS11674.1
      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Related
      ENSP00000501934.1, ENST00000674770.2
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    11. NM_001346474.2NP_001333403.1  archaemetzincin-2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 1-5, 7-11, and 13-17, encodes isoform 1.
      Source sequence(s)
      AC005332
      Consensus CDS
      CCDS11674.1
      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    12. NM_001346475.2NP_001333404.1  archaemetzincin-2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 1-5, 7-12, and 14-17, encodes isoform 1.
      Source sequence(s)
      AC005332
      Consensus CDS
      CCDS11674.1
      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    13. NM_001346476.2NP_001333405.1  archaemetzincin-2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 1-5, 7-13, and 15-17, encodes isoform 1.
      Source sequence(s)
      AC005332
      Consensus CDS
      CCDS11674.1
      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    14. NM_001346477.2NP_001333406.1  archaemetzincin-2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 1-5, 7-14, and 16-17, encodes isoform 1.
      Source sequence(s)
      AC005332
      Consensus CDS
      CCDS11674.1
      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Related
      ENSP00000464133.1, ENST00000577866.5
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    15. NM_001346478.2NP_001333407.1  archaemetzincin-2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 1-5, 7-15, and 17, encodes isoform 1.
      Source sequence(s)
      AC005332
      Consensus CDS
      CCDS11674.1
      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    16. NM_001346479.2NP_001333408.1  archaemetzincin-2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 1-5 and 7-16, encodes isoform 1.
      Source sequence(s)
      AC005332
      Consensus CDS
      CCDS11674.1
      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    17. NM_001346480.1NP_001333409.1  archaemetzincin-2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variant 6, encodes isoform 2.
      Source sequence(s)
      AC005332
      Consensus CDS
      CCDS32714.1
      UniProtKB/Swiss-Prot
      Q86W34
    18. NM_001346481.1NP_001333410.1  archaemetzincin-2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 20-22, encodes isoform 3.
      Source sequence(s)
      AC005332
      Conserved Domains (1) summary
      cd11375
      Location:69263
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    19. NM_001346482.1NP_001333411.1  archaemetzincin-2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 19 and 21-22, encodes isoform 3.
      Source sequence(s)
      AC005332
      Conserved Domains (1) summary
      cd11375
      Location:69263
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    20. NM_001346483.2NP_001333412.1  archaemetzincin-2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 19-20 and 22, encodes isoform 3.
      Source sequence(s)
      AC005332
      Conserved Domains (1) summary
      cd11375
      Location:69263
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    21. NM_001346484.2NP_001333413.1  archaemetzincin-2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variants 19-21, encodes isoform 3.
      Source sequence(s)
      AC005332
      Conserved Domains (1) summary
      cd11375
      Location:69263
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    22. NM_001346485.2NP_001333414.1  archaemetzincin-2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC005332
    23. NM_016627.5NP_057711.3  archaemetzincin-2 isoform 1

      See identical proteins and their annotated locations for NP_057711.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1-5 and 7-17 all encode the same isoform (1).
      Source sequence(s)
      AK126146, BQ432895
      Consensus CDS
      CCDS11674.1
      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Related
      ENSP00000352976.3, ENST00000359904.8
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins

    RNA

    1. NR_144442.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005332
    2. NR_144443.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005332

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      68206129..68257164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450788.2XP_024306556.1  archaemetzincin-2 isoform X1

      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    2. XM_047436210.1XP_047292166.1  archaemetzincin-2 isoform X1

      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    3. XM_024450786.2XP_024306554.1  archaemetzincin-2 isoform X1

      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    4. XM_024450787.2XP_024306555.1  archaemetzincin-2 isoform X1

      UniProtKB/Swiss-Prot
      A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
      Conserved Domains (1) summary
      cd11375
      Location:89297
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    5. XM_047436211.1XP_047292167.1  archaemetzincin-2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      69082913..69133740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316368.1XP_054172343.1  archaemetzincin-2 isoform X1

    2. XM_054316369.1XP_054172344.1  archaemetzincin-2 isoform X1

    3. XM_054316370.1XP_054172345.1  archaemetzincin-2 isoform X1

    4. XM_054316371.1XP_054172346.1  archaemetzincin-2 isoform X2