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    AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 [ Homo sapiens (human) ]

    Gene ID: 56895, updated on 3-Nov-2024

    Summary

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    Official Symbol
    AGPAT4provided by HGNC
    Official Full Name
    1-acylglycerol-3-phosphate O-acyltransferase 4provided by HGNC
    Primary source
    HGNC:HGNC:20885
    See related
    Ensembl:ENSG00000026652 MIM:614795; AllianceGenome:HGNC:20885
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LPAAT4; LPLAT4; 1-AGPAT4; dJ473J16.2; LPAAT-delta
    Summary
    This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in brain (RPKM 9.7), placenta (RPKM 3.7) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See AGPAT4 in Genome Data Viewer
    Location:
    6q26
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (161129967..161274061, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (162488365..162632384, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (161550999..161695093, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378093 Neighboring gene uncharacterized LOC102724087 Neighboring gene Sharpr-MPRA regulatory region 6130 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:161396855-161397569 Neighboring gene MPRA-validated peak6299 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25407 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:161412339-161413208 Neighboring gene Sharpr-MPRA regulatory region 85 Neighboring gene NANOG hESC enhancer GRCh37_chr6:161422459-161422960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25410 Neighboring gene MPRA-validated peak6300 silencer Neighboring gene MAP3K4 antisense RNA 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:161500530-161501729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25411 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:161549261-161550460 Neighboring gene Sharpr-MPRA regulatory region 15502 Neighboring gene uncharacterized LOC124901455 Neighboring gene mitogen-activated protein kinase kinase kinase 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:161579309-161579810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:161582962-161583462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:161581716-161582274 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:161579811-161580310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:161586885-161587594 Neighboring gene NANOG hESC enhancer GRCh37_chr6:161589077-161589672 Neighboring gene Sharpr-MPRA regulatory region 12533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25412 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:161606735-161607934 Neighboring gene AGPAT4 intronic transcript 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:161644168-161644410 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:161647413-161647718 Neighboring gene Sharpr-MPRA regulatory region 4197 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:161713123-161713635 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:161724387-161725586 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:161736020-161737219 Neighboring gene uncharacterized LOC105378094 Neighboring gene uncharacterized LOC124901457 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:161775686-161776186 Neighboring gene parkin RBR E3 ubiquitin protein ligase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels. Bradley RM, et al. Biochim Biophys Acta, 2015 Dec. PMID 26417903
    2. The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages. Zhang D, et al. Signal Transduct Target Ther, 2020 Mar 27. PMID 32296017, Free PMC Article
    3. The structure and functions of human lysophosphatidic acid acyltransferases. Leung DW. Front Biosci, 2001 Aug 1. PMID 11487472
    4. Genome-wide association study of co-occurring anxiety in major depression. Schosser A, et al. World J Biol Psychiatry, 2013 Dec. PMID 24047446
    5. Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart. Lu B, et al. Biochem J, 2005 Jan 15. PMID 15367102, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages.
      Title: The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of co-occurring anxiety in major depression.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidic acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in phospholipid biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    1-acyl-sn-glycerol-3-phosphate acyltransferase delta
    Names
    1-AGP acyltransferase 4
    1-AGPAT 4
    1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
    lysophosphatidic acid acyltransferase delta
    lysophosphatidic acid acyltransferase-delta (LPAAT-delta)
    lysophospholipid acyltransferase 4
    NP_064518.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020133.3 → NP_064518.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta

      See identical proteins and their annotated locations for NP_064518.1

      Status: REVIEWED

      Source sequence(s)
      AF156776, AL109942, AL122123, BQ072907
      Consensus CDS
      CCDS5280.1
      UniProtKB/Swiss-Prot
      B4DSF9, Q5TEF0, Q9NRZ5
      Related
      ENSP00000314036.4, ENST00000320285.9
      Conserved Domains (3) summary
      cd07990
      Location:62 → 256
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PLN02380
      Location:20 → 345
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
      pfam16076
      Location:243 → 314
      Acyltransf_C; Acyltransferase C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      161129967..161274061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      162488365..162632384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001012733.1: Suppressed sequence

      Description
      NM_001012733.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_001012734.1: Suppressed sequence

      Description
      NM_001012734.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NRZ5.1 GenPept UniProtKB/Swiss-Prot:Q9NRZ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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