SLK STE20 like kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLKprovided by HGNC
Official Full Name: STE20 like kinaseprovided by HGNC
Primary source: HGNC:HGNC:11088
See related: Ensembl:ENSG00000065613 MIM:616563; AllianceGenome:HGNC:11088
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LOSK; STK2; se20-9; bA16H23.1
Summary: Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including cytoplasmic microtubule organization; protein autophosphorylation; and regulation of focal adhesion assembly. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in esophagus (RPKM 35.4), lung (RPKM 15.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q24.33-q25.1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (103967140..104029233)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (104854380..104916616)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (105726898..105788991)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLK-mediated actin cytoskeletal reorganization may facilitate force transmission between the contractile units and the extracellular matrix.
Title: Ste20-like Kinase-mediated Control of Actin Polymerization Is a New Mechanism for Thin Filament-associated Regulation of Airway Smooth Muscle Contraction.
The inhibition of SLK by RNA interference significantly suppressed the invasion ability of glioma, and on protein level, knock- down of SLK leaded to an up-regulation of E-cadherin and a down-regulation of Vimentin in glioma cells.
Title: Ste20-like kinase is upregulated in glioma and induces glioma invasion.
SLK interacts with Tpr and alpha-actinin-4 in cells, and these protein-protein interactions may control the subcellular localization and the biological activity of SLK.
Title: Identification of Tpr and α-actinin-4 as two novel SLK-interacting proteins.
SLK activated ERMs, together with Galphai, are critical for the correct localization of LGN-NuMA force generator complexes and hence for proper spindle orientation.
Title: SLK-dependent activation of ERMs controls LGN-NuMA localization and spindle orientation.
The fact that SLK (LOSK) phosphorylates only a minor isoform 1A of p150(Glued) suggests that transport and microtubule-organizing functions of dynactin are distinctly divided between the two isoforms
Title: Ste20-like protein kinase SLK (LOSK) regulates microtubule organization by targeting dynactin to the centrosome.
It was shown that lymphocyte-oriented and STE20 kinase were sufficient to restrict ezrin function to the apical domain. Both kinases were enriched in microvilli and locally activated there.
Title: Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells.
Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Studies define an interaction between Neu and SLK signaling in the regulation of cancer cell motility.
Title: The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility.
Protein kinase LOSK is required for radial microtubule organization and for the proper localization of Golgi complex in various cell types.
Title: Ste20-related protein kinase LOSK (SLK) controls microtubule radial array in interphase.
we show that a novel isoform of SPS1-related proline alanine-rich kinase (SPAK/STE20) is involved in this inflammatory signaling cascade
Title: Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10S2248 (e-PCR)
- UniSTS:75810

RH25417 (e-PCR)
- UniSTS:88178

SLK_8987 (e-PCR)
- UniSTS:468139

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables cadherin binding	HDA more info	PubMed
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of focal adhesion assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell leading edge	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: STE20-like serine/threonine-protein kinase

Names: CTCL tumor antigen se20-9; Long Ste20-like Kinase; SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase; SNF1 sucrose nonfermenting like kinase; STE20-related kinase; STE20-related serine/threonine-protein kinase; Ste20-related serine/threonine kinase; hSLK; serine/threonine-protein kinase 2

NP_001291672.1

EC 2.7.11.1

NP_055535.2

EC 2.7.11.1

XP_011538703.1

EC 2.7.11.1

XP_047281995.1

EC 2.7.11.1

XP_054223219.1

EC 2.7.11.1

XP_054223220.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001304743.2 → NP_001291672.1 STE20-like serine/threonine-protein kinase isoform 2

See identical proteins and their annotated locations for NP_001291672.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter isoform (2) compared to isoform 1.

Source sequence(s)

AL138761, AL360170, BC008697, BC047885, BC111565

Consensus CDS

CCDS76334.1

UniProtKB/TrEMBL

B4DZC9

Related

ENSP00000336824.4, ENST00000335753.8

Conserved Domains (3) summary

smart00220
Location:34 → 292

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06643
Location:28 → 309

STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase

pfam12474
Location:989 → 1129

PKK; Polo kinase kinase
NM_014720.4 → NP_055535.2 STE20-like serine/threonine-protein kinase isoform 1

See identical proteins and their annotated locations for NP_055535.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF273048, AL138761, AL360170, BC047885

Consensus CDS

CCDS7553.1

UniProtKB/Swiss-Prot

D3DRA0, D3DRA1, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9H2G2, Q9NQL0, Q9NQL1

UniProtKB/TrEMBL

B4DZC9

Related

ENSP00000358770.3, ENST00000369755.4

Conserved Domains (3) summary

smart00220
Location:34 → 292

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06643
Location:28 → 309

STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase

pfam12474
Location:1020 → 1160

PKK; Polo kinase kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

103967140..104029233

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011540401.4 → XP_011538703.1 STE20-like serine/threonine-protein kinase isoform X1

Conserved Domains (3) summary

smart00220
Location:34 → 292

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06643
Location:28 → 309

STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase

pfam12474
Location:568 → 708

PKK; Polo kinase kinase
XM_047426039.1 → XP_047281995.1 STE20-like serine/threonine-protein kinase isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

104854380..104916616

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054367244.1 → XP_054223219.1 STE20-like serine/threonine-protein kinase isoform X1
XM_054367245.1 → XP_054223220.1 STE20-like serine/threonine-protein kinase isoform X2