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    Ssr2 signal sequence receptor, beta [ Mus musculus (house mouse) ]

    Gene ID: 66256, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ssr2provided by MGI
    Official Full Name
    signal sequence receptor, betaprovided by MGI
    Primary source
    MGI:MGI:1913506
    See related
    Ensembl:ENSMUSG00000041355 AllianceGenome:MGI:1913506
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TLAP; TRAPB; SSR-beta; TRAPbeta; 1500032E05Rik
    Summary
    Acts upstream of or within in utero embryonic development. Predicted to be located in endoplasmic reticulum membrane. Is expressed in cranium; genitourinary system; and pancreas epithelium. Orthologous to human SSR2 (signal sequence receptor subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 192.7), large intestine adult (RPKM 147.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ssr2 in Genome Data Viewer
    Location:
    3 F1; 3 38.88 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88486915..88495727)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88579608..88588420)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8803 Neighboring gene ubiquilin 4 Neighboring gene STARR-seq mESC enhancer starr_08200 Neighboring gene STARR-seq mESC enhancer starr_08201 Neighboring gene STARR-positive B cell enhancer ABC_E6069 Neighboring gene RNA transcription, translation and transport factor, pseudogene Neighboring gene STARR-seq mESC enhancer starr_08203 Neighboring gene STARR-seq mESC enhancer starr_08204 Neighboring gene STARR-positive B cell enhancer ABC_E9078 Neighboring gene STARR-positive B cell enhancer ABC_E6070 Neighboring gene predicted gene, 52660 Neighboring gene Rho/Rac guanine nucleotide exchange factor 2 Neighboring gene predicted gene, 40090

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The concept of translocational regulation. Hegde RS, et al. J Cell Biol, 2008 Jul 28. PMID 18644895, Free PMC Article
    2. Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease. Radford BN, et al. Nat Commun, 2023 Mar 1. PMID 36859534, Free PMC Article
    3. High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis. Uematsu R, et al. Mol Cell Proteomics, 2005 Dec. PMID 16170054
    4. Inceptor counteracts insulin signalling in β-cells to control glycaemia. Ansarullah, et al. Nature, 2021 Feb. PMID 33505018
    5. A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells. Roma G, et al. Genome Res, 2007 Jul. PMID 17540781, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    translocon-associated protein subunit beta
    Names
    signal sequence receptor subunit beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356316.1 → NP_001343245.1  translocon-associated protein subunit beta isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC145168
      Consensus CDS
      CCDS89648.1
      UniProtKB/TrEMBL
      A0A0A6YXB7
      Related
      ENSMUSP00000141922.2, ENSMUST00000192495.6
      Conserved Domains (1) summary
      pfam05753
      Location:15 → 181
      TRAP_beta; Translocon-associated protein beta (TRAPB)

    2. NM_001356317.1 → NP_001343246.1  translocon-associated protein subunit beta isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC145168, AK005340
      Consensus CDS
      CCDS17480.1
      UniProtKB/Swiss-Prot
      Q91Z43, Q9CPW5, Q9CR94, Q9CX54
      Related
      ENSMUSP00000141441.2, ENSMUST00000195014.6
      Conserved Domains (1) summary
      pfam05753
      Location:15 → 179
      TRAP_beta; Translocon-associated protein beta (TRAPB)

    3. NM_001356318.1 → NP_001343247.1  translocon-associated protein subunit beta isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC145168
      Conserved Domains (1) summary
      pfam05753
      Location:15 → 177
      TRAP_beta; Translocon-associated protein beta (TRAPB)

    4. NM_001356319.1 → NP_001343248.1  translocon-associated protein subunit beta isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC145168
      Consensus CDS
      CCDS89649.1
      UniProtKB/TrEMBL
      A0A0A6YVZ1
      Related
      ENSMUSP00000141325.2, ENSMUST00000193934.6
      Conserved Domains (1) summary
      pfam05753
      Location:15 → 160
      TRAP_beta; Translocon-associated protein beta (TRAPB)

    5. NM_025448.4 → NP_079724.1  translocon-associated protein subunit beta isoform 2 precursor

      See identical proteins and their annotated locations for NP_079724.1

      Status: VALIDATED

      Source sequence(s)
      AC145168, AK050505
      Consensus CDS
      CCDS17480.1
      UniProtKB/Swiss-Prot
      Q91Z43, Q9CPW5, Q9CR94, Q9CX54
      Related
      ENSMUSP00000045456.8, ENSMUST00000035785.9
      Conserved Domains (1) summary
      pfam05753
      Location:15 → 179
      TRAP_beta; Translocon-associated protein beta (TRAPB)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      88486915..88495727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPW5.1 GenPept UniProtKB/Swiss-Prot:Q9CPW5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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