Cldn15 claudin 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cldn15provided by MGI
Official Full Name: claudin 15provided by MGI
Primary source: MGI:MGI:1913103
See related: Ensembl:ENSMUSG00000001739 AllianceGenome:MGI:1913103
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2210009B08Rik
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein increases permeability for sodium ions in anion-selective epithelial cell sheets. The gene deficiency leads to megaintestine and decreases in intestinal epithelial paracellular ion permeability. This gene is a direct target for hepatocyte-nuclear-factor-4alpha, a mediator of ion epithelial transport, and is down-modulated in inflammatory bowel disease. [provided by RefSeq, Aug 2010]
Expression: Biased expression in duodenum adult (RPKM 299.4), large intestine adult (RPKM 256.9) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.07 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (136996723..137004699)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (136967869..136975845)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The effect of claudin-15 deletion on cationic selectivity and transport in paracellular pathways of the cecum and large intestine.
Title: The effect of claudin-15 deletion on cationic selectivity and transport in paracellular pathways of the cecum and large intestine.
Na(+)-Coupled Nutrient Cotransport Induced Luminal Negative Potential and Claudin-15 Play an Important Role in Paracellular Na(+) Recycling in Mouse Small Intestine.
Title: Na(+)-Coupled Nutrient Cotransport Induced Luminal Negative Potential and Claudin-15 Play an Important Role in Paracellular Na(+) Recycling in Mouse Small Intestine.
structure of claudin-15 at a resolution of 2.4 angstroms; structure reveals a characteristic beta-sheet fold comprising 2 extracellular segments, which is anchored to a transmembrane four-helix bundle by a consensus motif; findings provide insight into molecular basis of ion homeostasis across tight junctions
Title: Crystal structure of a claudin provides insight into the architecture of tight junctions.
Claudin-15 knockout leads to Na(+) deficiency and glucose malabsorption in the mouse adult small intestine.
Title: Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine.
Claudin-15-based formation of tight junctions to organize the microenvironment including ion conductance is important for normal-sized morphogenesis of the small intestine.
Title: Megaintestine in claudin-15-deficient mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables paracellular tight junction channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bicellular tight junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in paracellular transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of intestinal D-glucose absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of intestinal lipid absorption	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in tight junction	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: claudin-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.