CELA2A chymotrypsin-like elastase family, member 2A [Sus scrofa (pig)] - Gene

Summary

Gene symbol: CELA2A
Gene description: chymotrypsin-like elastase family, member 2A
See related: Ensembl:ENSSSCG00000003459
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: ELA2; ELANE
Expression: Ubiquitous expression in ovary (RPKM 8.7), longissimus dorsi muscle (RPKM 2.7) and 8 other tissues See more
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Genomic context

Location:: chromosome: 6

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	6	NC_010448.4 (74691653..74707598)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	6	NC_010448.3 (69072038..69088197)

Chromosome 6 - NC_010448.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

ELA1 (e-PCR)
- UniSTS:253973

SWR1642 (e-PCR)
- UniSTS:252957

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: chymotrypsin-like elastase family member 2A

Names: elastase 2, neutrophil; elastase-2; elastase-2A; pancreatic elastase II

NP_999274.1

EC 3.4.21.71

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214109.1 → NP_999274.1 chymotrypsin-like elastase family member 2A preproprotein

See identical proteins and their annotated locations for NP_999274.1

Status: VALIDATED

Source sequence(s)

M16651

UniProtKB/Swiss-Prot

P08419

UniProtKB/TrEMBL

A0A8D0KHQ6

Related

ENSSSCP00000003756.1, ENSSSCT00000003844.2

Conserved Domains (2) summary

smart00020
Location:28 → 262

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:29 → 265

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...