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    Arrdc5 arrestin domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 76920, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Arrdc5provided by MGI
    Official Full Name
    arrestin domain containing 5provided by MGI
    Primary source
    MGI:MGI:1924170
    See related
    Ensembl:ENSMUSG00000073380 AllianceGenome:MGI:1924170
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700013E09Rik
    Summary
    Predicted to be involved in protein transport. Predicted to be active in endosome and plasma membrane. Orthologous to human ARRDC5 (arrestin domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 106.5) See more
    Orthologs
    human all
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    Genomic context

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    See Arrdc5 in Genome Data Viewer
    Location:
    17 29.26 cM; 17 D
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56601111..56607262, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56294111..56300286, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1945 Neighboring gene STARR-positive B cell enhancer ABC_E11798 Neighboring gene TIR domain containing adaptor molecule 1 Neighboring gene STARR-positive B cell enhancer ABC_E8686 Neighboring gene STARR-positive B cell enhancer ABC_E3207 Neighboring gene perilipin 3 Neighboring gene STARR-positive B cell enhancer ABC_E3208 Neighboring gene STARR-positive B cell enhancer ABC_E3209 Neighboring gene ubiquitin-like, containing PHD and RING finger domains, 1 Neighboring gene STARR-positive B cell enhancer ABC_E141 Neighboring gene lysine (K)-specific demethylase 4B Neighboring gene STARR-positive B cell enhancer ABC_E8923 Neighboring gene predicted gene, 32715

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ARRDC5 deficiency impairs spermatogenesis by affecting SUN5 and NDC1. Liu R, et al. Development, 2023 Dec 15. PMID 37997706
    2. ARRDC5 expression is conserved in mammalian testes and required for normal sperm morphogenesis. Giassetti MI, et al. Nat Commun, 2023 Apr 17. PMID 37069147, Free PMC Article
    3. Accelerating functional gene discovery in osteoarthritis. Butterfield NC, et al. Nat Commun, 2021 Jan 20. PMID 33473114, Free PMC Article
    4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARRDC5 deficiency impairs spermatogenesis by affecting SUN5 and NDC1.
      Title: ARRDC5 deficiency impairs spermatogenesis by affecting SUN5 and NDC1.
    2. ARRDC5 expression is conserved in mammalian testes and required for normal sperm morphogenesis.
      Title: ARRDC5 expression is conserved in mammalian testes and required for normal sperm morphogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Targeted (2) 

    General gene information

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    Homology

    Clone Names

    • MGC118336

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    arrestin domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029799.2 → NP_084075.1  arrestin domain-containing protein 5

      See identical proteins and their annotated locations for NP_084075.1

      Status: VALIDATED

      Source sequence(s)
      AC026385
      Consensus CDS
      CCDS28902.1
      UniProtKB/Swiss-Prot
      Q497K5
      Related
      ENSMUSP00000094906.2, ENSMUST00000097303.3
      Conserved Domains (2) summary
      pfam02752
      Location:170 → 304
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:13 → 128
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56601111..56607262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q497K5.1 GenPept UniProtKB/Swiss-Prot:Q497K5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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