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    Ackr4 atypical chemokine receptor 4 [ Mus musculus (house mouse) ]

    Gene ID: 252837, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ackr4provided by MGI
    Official Full Name
    atypical chemokine receptor 4provided by MGI
    Primary source
    MGI:MGI:2181676
    See related
    Ensembl:ENSMUSG00000079355 AllianceGenome:MGI:2181676
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PPR1; CCBP2; CCR11; Ccrl1; VSHK1; CCX-CKR; Cmkbrl1; CCX-CKR1; A630091E18Rik
    Summary
    Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to be located in early endosome; plasma membrane; and recycling endosome. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including central nervous system; gut; immune system; male reproductive gland or organ; and sensory organ. Orthologous to human ACKR4 (atypical chemokine receptor 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in genital fat pad adult (RPKM 3.0), colon adult (RPKM 2.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ackr4 in Genome Data Viewer
    Location:
    9 F1; 9 56.47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (103974881..104003842, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (104097682..104126643, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:103965595-103965778 Neighboring gene STARR-seq mESC enhancer starr_25105 Neighboring gene ubiquitin-like modifier activating enzyme 5 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 11 Neighboring gene STARR-seq mESC enhancer starr_25106 Neighboring gene STARR-seq mESC enhancer starr_25110 Neighboring gene DnaJ heat shock protein family (Hsp40) member C13 Neighboring gene high mobility group box 1, related sequence 16 Neighboring gene predicted gene, 46130

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Astrocytes express functional chemokine receptors. Dorf ME, et al. J Neuroimmunol, 2000 Nov 1. PMID 11063828
    2. A silent chemokine receptor regulates steady-state leukocyte homing in vivo. Heinzel K, et al. Proc Natl Acad Sci U S A, 2007 May 15. PMID 17485674, Free PMC Article
    3. Regenerative capacity of adult cortical thymic epithelial cells. Rode I, et al. Proc Natl Acad Sci U S A, 2012 Feb 28. PMID 22331880, Free PMC Article
    4. CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity. Bunting MD, et al. Blood, 2013 Jan 3. PMID 23152546
    5. The atypical chemokine receptor CCX-CKR regulates metastasis of mammary carcinoma via an effect on EMT. Harata-Lee Y, et al. Immunol Cell Biol, 2014 Nov. PMID 25027038

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension.
      Title: Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension.
    2. Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics.
      Title: Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics.
    3. Expression of ACKR4 demarcates the ""peri-marginal sinus,"" a specialized vascular compartment of the splenic red pulp.
      Title: Expression of ACKR4 demarcates the "peri-marginal sinus," a specialized vascular compartment of the splenic red pulp.
    4. Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration.
      Title: Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration.
    5. Inhibition of fibroblast IL-6 production by ACKR4 deletion alleviates cardiac remodeling after myocardial infarction.
      Title: Inhibition of fibroblast IL-6 production by ACKR4 deletion alleviates cardiac remodeling after myocardial infarction.
    6. ACKR4 restrains antitumor immunity by regulating CCL21.
      Title: ACKR4 restrains antitumor immunity by regulating CCL21.
    7. CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4.
      Title: CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4.
    8. B cell hyperactivation in an Ackr4-deficient mouse strain is not caused by lack of ACKR4 expression.
      Title: B cell hyperactivation in an Ackr4-deficient mouse strain is not caused by lack of ACKR4 expression.
    9. atypical chemokine receptor 4 (ACKR4), is a identified a decoy receptor that binds and degrades CCR7 ligands CCL19/CCL21, as a regulator of early activated B cell differentiation.
      Title: Atypical chemokine receptor 4 shapes activated B cell fate.
    10. a comprehensive model of CCL19 and CCL21 transport and gradient formation in the lymph nodes (LNs) was built; predicts that ACKR4 in LNs prevents CCL19/CCL21 accumulation in efferent lymph, but does not control intranodal gradients; instead, it attributes the disrupted interfollicular CCL21 gradients observed in Ackr4-deficient LNs to ACKR4 loss upstream
      Title: A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chemokine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chemokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chemokine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    atypical chemokine receptor 4
    Names
    C-C CKR-11
    C-C chemokine receptor type 11
    CC chemokine receptor-like 1
    CC-CKR-11
    CCR-11
    CCX CKR
    chemokine (C-C motif) receptor-like 1
    chemokine (C-C) receptor-like 1
    chemokine receptor CCR11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145700.2 → NP_663746.2  atypical chemokine receptor 4

      See identical proteins and their annotated locations for NP_663746.2

      Status: VALIDATED

      Source sequence(s)
      AC145736, AK030643, AK042430, BB151172, BC140999
      Consensus CDS
      CCDS23459.1
      UniProtKB/Swiss-Prot
      Q8C0M1, Q8QZW9, Q924I3
      UniProtKB/TrEMBL
      B2RU75
      Related
      ENSMUSP00000075507.4, ENSMUST00000076147.6
      Conserved Domains (1) summary
      cd15176
      Location:42 → 314
      7tmA_ACKR4_CCR11; atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      103974881..104003842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511735.5 → XP_006511798.1  atypical chemokine receptor 4 isoform X1

      See identical proteins and their annotated locations for XP_006511798.1

      UniProtKB/Swiss-Prot
      Q8C0M1, Q8QZW9, Q924I3
      UniProtKB/TrEMBL
      B2RU75
      Related
      ENSMUSP00000140792.2, ENSMUST00000188000.2
      Conserved Domains (1) summary
      cd15176
      Location:42 → 314
      7tmA_ACKR4_CCR11; atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924I3.1 GenPept UniProtKB/Swiss-Prot:Q924I3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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