Nudt5 nudix hydrolase 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nudt5provided by MGI
Official Full Name: nudix hydrolase 5provided by MGI
Primary source: MGI:MGI:1858232
See related: Ensembl:ENSMUSG00000025817 AllianceGenome:MGI:1858232
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables nucleoside diphosphate phosphatase activity and snoRNA binding activity. Acts upstream of or within nucleobase-containing compound metabolic process. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and respiratory system. Orthologous to human NUDT5 (nudix hydrolase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 10.2), liver E14 (RPKM 9.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A1; 2 3.62 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (5849839..5875631)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (5845034..5870820)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nudt5 (e-PCR), detects polymorphism
- UniSTS:164926

NoName (e-PCR)
- UniSTS:234322

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables 8-oxo-GDP phosphatase activity	IEA Inferred from Electronic Annotation more info
enables 8-oxo-dGDP phosphatase activity	ISO Inferred from Sequence Orthology more info
enables 8-oxo-dGDP phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ADP-ribose diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ADP-ribose diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables ADP-ribose diphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ADP-sugar diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables ADP-sugar diphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleoside diphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleotidyltransferase activity	ISO Inferred from Sequence Orthology more info
enables nucleotidyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables snoRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP generation from poly-ADP-D-ribose	IEA Inferred from Electronic Annotation more info
involved_in ATP generation from poly-ADP-D-ribose	ISO Inferred from Sequence Orthology more info
involved_in D-ribose catabolic process	ISO Inferred from Sequence Orthology more info
involved_in D-ribose catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nucleobase-containing compound metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleoside phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribonucleoside diphosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ribonucleoside diphosphate catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribose phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ADP-sugar pyrophosphatase

Names: 8-oxo-dGDP phosphatase; nuclear ATP-synthesis protein NUDIX5; nucleoside diphosphate-linked moiety X motif 5; nudix (nucleoside diphosphate linked moiety X)-type motif 5; nudix motif 5

NP_001405336.1

EC 2.7.7.96

EC 3.6.1.13

EC 3.6.1.58

NP_001405337.1

EC 2.7.7.96

EC 3.6.1.13

EC 3.6.1.58

NP_001405338.1

EC 2.7.7.96

EC 3.6.1.13

EC 3.6.1.58

NP_001405339.1

EC 2.7.7.96

EC 3.6.1.13

EC 3.6.1.58

NP_001405340.1

EC 2.7.7.96

EC 3.6.1.13

EC 3.6.1.58

NP_001405341.1

EC 2.7.7.96

EC 3.6.1.13

EC 3.6.1.58

NP_001405342.1

EC 2.7.7.96

EC 3.6.1.13

EC 3.6.1.58

NP_001405343.1

EC 2.7.7.96

EC 3.6.1.13

EC 3.6.1.58

NP_001405344.1

EC 2.7.7.96

EC 3.6.1.13

EC 3.6.1.58

NP_001405345.1

EC 2.7.7.96

EC 3.6.1.13

EC 3.6.1.58

NP_001405346.1

EC 2.7.7.96

EC 3.6.1.13

EC 3.6.1.58

NP_058614.1

EC 2.7.7.96

EC 3.6.1.13

EC 3.6.1.58

XP_006497574.1

EC 2.7.7.96

EC 3.6.1.13

EC 3.6.1.58

XP_036018286.1

EC 2.7.7.96

EC 3.6.1.13

EC 3.6.1.58

XP_036018287.1

EC 2.7.7.96

EC 3.6.1.13

EC 3.6.1.58

XP_036018288.1

EC 2.7.7.96

EC 3.6.1.13

EC 3.6.1.58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418407.1 → NP_001405336.1 ADP-sugar pyrophosphatase isoform b

Status: VALIDATED

Source sequence(s)

AL928924
NM_001418408.1 → NP_001405337.1 ADP-sugar pyrophosphatase isoform b

Status: VALIDATED

Source sequence(s)

AL928924
NM_001418409.1 → NP_001405338.1 ADP-sugar pyrophosphatase isoform c

Status: VALIDATED

Source sequence(s)

AL928924
NM_001418410.1 → NP_001405339.1 ADP-sugar pyrophosphatase isoform c

Status: VALIDATED

Source sequence(s)

AL928924
NM_001418411.1 → NP_001405340.1 ADP-sugar pyrophosphatase isoform c

Status: VALIDATED

Source sequence(s)

AL928924
NM_001418412.1 → NP_001405341.1 ADP-sugar pyrophosphatase isoform c

Status: VALIDATED

Source sequence(s)

AL928924
NM_001418413.1 → NP_001405342.1 ADP-sugar pyrophosphatase isoform c

Status: VALIDATED

Source sequence(s)

AL928924

Related

ENSMUSP00000117670.2, ENSMUST00000127116.7
NM_001418414.1 → NP_001405343.1 ADP-sugar pyrophosphatase isoform c

Status: VALIDATED

Source sequence(s)

AL928924
NM_001418415.1 → NP_001405344.1 ADP-sugar pyrophosphatase isoform d

Status: VALIDATED

Source sequence(s)

AL928924
NM_001418416.1 → NP_001405345.1 ADP-sugar pyrophosphatase isoform d

Status: VALIDATED

Source sequence(s)

AL928924
NM_001418417.1 → NP_001405346.1 ADP-sugar pyrophosphatase isoform d

Status: VALIDATED

Source sequence(s)

AL928924
NM_016918.4 → NP_058614.1 ADP-sugar pyrophosphatase isoform a

See identical proteins and their annotated locations for NP_058614.1

Status: VALIDATED

Source sequence(s)

AL928924

Consensus CDS

CCDS15667.1

UniProtKB/Swiss-Prot

A2ATT6, Q99KM4, Q9JKX6

Related

ENSMUSP00000026927.4, ENSMUST00000026927.10

Conserved Domains (1) summary

cd03424
Location:59 → 206

ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

5849839..5875631

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162394.1 → XP_036018287.1 ADP-sugar pyrophosphatase isoform X3

UniProtKB/Swiss-Prot

A2ATT6, Q99KM4, Q9JKX6

Conserved Domains (1) summary

cd03424
Location:59 → 206

ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...
XM_036162395.1 → XP_036018288.1 ADP-sugar pyrophosphatase isoform X3

UniProtKB/Swiss-Prot

A2ATT6, Q99KM4, Q9JKX6

Conserved Domains (1) summary

cd03424
Location:59 → 206

ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...
XM_006497511.4 → XP_006497574.1 ADP-sugar pyrophosphatase isoform X2

Conserved Domains (1) summary

cd03424
Location:105 → 249

ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...
XM_036162393.1 → XP_036018286.1 ADP-sugar pyrophosphatase isoform X1

Conserved Domains (1) summary

cd03424
Location:105 → 252

ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...