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    Gmeb1 glucocorticoid modulatory element binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 56809, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gmeb1provided by MGI
    Official Full Name
    glucocorticoid modulatory element binding protein 1provided by MGI
    Primary source
    MGI:MGI:2135604
    See related
    Ensembl:ENSMUSG00000028901 AllianceGenome:MGI:2135604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110050A04Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in central nervous system; early conceptus; genitourinary system; limb; and sensory organ. Orthologous to human GMEB1 (glucocorticoid modulatory element binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.7), CNS E14 (RPKM 3.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gmeb1 in Genome Data Viewer
    Location:
    4 D2.3; 4 64.99 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (131948336..131988919, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132221025..132261609, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene YTH N6-methyladenosine RNA binding protein 2 Neighboring gene ribosomal protein S15A, pseudogene 4 Neighboring gene cytochrome c-like Neighboring gene predicted gene 28874 Neighboring gene STARR-positive B cell enhancer ABC_E3519 Neighboring gene U11 small nuclear RNA Neighboring gene TATA-box binding protein associated factor 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function. Tuesta LM, et al. Nat Commun, 2019 Jun 7. PMID 31175277, Free PMC Article
    2. A WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactions. Maitra R, et al. Nucleic Acids Res, 2009 Jun. PMID 19324890, Free PMC Article
    3. Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury. Tsuruma K, et al. J Biol Chem, 2006 Apr 21. PMID 16497673
    4. Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family. Jimenez-Lara AM, et al. FEBS Lett, 2000 Feb 25. PMID 10692587
    5. Discovery of novel protein partners of the transcription factor FOXL2 provides insights into its physiopathological roles. L'Hôte D, et al. Hum Mol Genet, 2012 Jul 15. PMID 22544055

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gmeb1 knockdown in midbrain dopamine (mDA) neurons resulted in downregulation of tyrosine hydroxylase and dopamine transporter, as well as in severe motor deficits. This study thus identifies Gmeb1 as a master regulator of mDA gene expression and function.
      Title: In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function.
    2. GMEB1 is an endogenous regulator that selectively binds to initiator procaspases and inhibits caspase-induced apoptosis
      Title: Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Hsp27 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp27 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glucocorticoid modulatory element-binding protein 1
    Names
    GMEB-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122992.1 → NP_001116464.1  glucocorticoid modulatory element-binding protein 1

      See identical proteins and their annotated locations for NP_001116464.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional exon in the 5' UTR, as compared to variant 1.
      Source sequence(s)
      AK134349, BU701415, BX537301, BY732360, DV660282
      Consensus CDS
      CCDS18720.1
      UniProtKB/Swiss-Prot
      Q80Y88, Q9JL60
      UniProtKB/TrEMBL
      Q3UYV4
      Related
      ENSMUSP00000101585.2, ENSMUST00000105965.8
      Conserved Domains (1) summary
      pfam01342
      Location:80 → 155
      SAND; SAND domain

    2. NM_020273.2 → NP_064669.2  glucocorticoid modulatory element-binding protein 1

      See identical proteins and their annotated locations for NP_064669.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same protein.
      Source sequence(s)
      AK134349, BU701415, BX537301, CN459906
      Consensus CDS
      CCDS18720.1
      UniProtKB/Swiss-Prot
      Q80Y88, Q9JL60
      UniProtKB/TrEMBL
      Q3UYV4
      Related
      ENSMUSP00000101584.2, ENSMUST00000105964.2
      Conserved Domains (1) summary
      pfam01342
      Location:80 → 155
      SAND; SAND domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      131948336..131988919 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164279.1 → XP_036020172.1  glucocorticoid modulatory element-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      Q3UYV4
      Conserved Domains (1) summary
      pfam01342
      Location:1 → 75
      SAND; SAND domain

    2. XM_006539080.5 → XP_006539143.1  glucocorticoid modulatory element-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006539143.1

      UniProtKB/Swiss-Prot
      Q80Y88, Q9JL60
      UniProtKB/TrEMBL
      Q3UYV4
      Conserved Domains (1) summary
      pfam01342
      Location:80 → 155
      SAND; SAND domain

    3. XM_036164277.1 → XP_036020170.1  glucocorticoid modulatory element-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q80Y88, Q9JL60
      UniProtKB/TrEMBL
      Q3UYV4
      Conserved Domains (1) summary
      pfam01342
      Location:80 → 155
      SAND; SAND domain

    4. XM_036164280.1 → XP_036020173.1  glucocorticoid modulatory element-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      Q3UYV4
      Conserved Domains (1) summary
      pfam01342
      Location:1 → 75
      SAND; SAND domain

    5. XM_006539079.5 → XP_006539142.1  glucocorticoid modulatory element-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006539142.1

      UniProtKB/Swiss-Prot
      Q80Y88, Q9JL60
      UniProtKB/TrEMBL
      Q3UYV4
      Conserved Domains (1) summary
      pfam01342
      Location:80 → 155
      SAND; SAND domain

    6. XM_017320332.3 → XP_017175821.1  glucocorticoid modulatory element-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q80Y88, Q9JL60
      UniProtKB/TrEMBL
      Q3UYV4
      Conserved Domains (1) summary
      pfam01342
      Location:80 → 155
      SAND; SAND domain

    7. XM_036164278.1 → XP_036020171.1  glucocorticoid modulatory element-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      Q3UYV4
      Conserved Domains (1) summary
      pfam01342
      Location:1 → 75
      SAND; SAND domain

    8. XM_036164275.1 → XP_036020168.1  glucocorticoid modulatory element-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q80Y88, Q9JL60
      UniProtKB/TrEMBL
      Q3UYV4
      Related
      ENSMUSP00000131331.2, ENSMUST00000168553.8
      Conserved Domains (1) summary
      pfam01342
      Location:80 → 155
      SAND; SAND domain

    9. XM_036164274.1 → XP_036020167.1  glucocorticoid modulatory element-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q80Y88, Q9JL60
      UniProtKB/TrEMBL
      Q3UYV4
      Related
      ENSMUSP00000030733.3, ENSMUST00000030733.9
      Conserved Domains (1) summary
      pfam01342
      Location:80 → 155
      SAND; SAND domain

    10. XM_006539078.4 → XP_006539141.1  glucocorticoid modulatory element-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006539141.1

      UniProtKB/Swiss-Prot
      Q80Y88, Q9JL60
      UniProtKB/TrEMBL
      Q3UYV4
      Conserved Domains (1) summary
      pfam01342
      Location:80 → 155
      SAND; SAND domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JL60.2 GenPept UniProtKB/Swiss-Prot:Q9JL60

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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