Socs2 suppressor of cytokine signaling 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Socs2provided by MGI
Official Full Name: suppressor of cytokine signaling 2provided by MGI
Primary source: MGI:MGI:1201787
See related: Ensembl:ENSMUSG00000020027 AllianceGenome:MGI:1201787
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: hg; JAB; CIS2; Cish2; SSI-2; SOCS-2; 8030460M17; D130043N08Rik
Summary: Enables growth hormone receptor binding activity and phosphorylation-dependent protein binding activity. Involved in negative regulation of growth hormone receptor signaling pathway. Acts upstream of or within several processes, including mammary gland development; negative regulation of receptor signaling pathway via JAK-STAT; and positive regulation of neuron differentiation. Predicted to be located in cytoplasm. Predicted to be part of Cul5-RING ubiquitin ligase complex. Is expressed in several structures, including lung; retina; spleen; testis; and ureteric tip. Human ortholog(s) of this gene implicated in endometrial cancer and ovarian carcinoma. Orthologous to human SOCS2 (suppressor of cytokine signaling 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 9.8), lung adult (RPKM 5.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C2; 10 49.35 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (95219765..95253176, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (95383903..95417321, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A loss of function mutation in SOCS2 results in increased inflammatory response of macrophages to TLR ligands and Staphylococcus aureus.
Title: A loss of function mutation in SOCS2 results in increased inflammatory response of macrophages to TLR ligands and Staphylococcus aureus.
Mutation of SOCS2 induces structural and functional changes in mammary development.
Title: Mutation of SOCS2 induces structural and functional changes in mammary development.
SOCS2 regulates alveolar bone loss in Aggregatibacter actinomycetemcomitans-induced periodontal disease.
Title: SOCS2 regulates alveolar bone loss in Aggregatibacter actinomycetemcomitans-induced periodontal disease.
SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine.
Title: SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine.
Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation.
Title: Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation.
Role of Suppressor of cytokine signaling 2 during the development and resolution of an experimental arthritis.
Title: Role of Suppressor of cytokine signaling 2 during the development and resolution of an experimental arthritis.
SOCS2 expression in hematopoietic and non-hematopoietic cells during Trypanosoma cruzi infection: Correlation with immune response and cardiac dysfunction.
Title: SOCS2 expression in hematopoietic and non-hematopoietic cells during Trypanosoma cruzi infection: Correlation with immune response and cardiac dysfunction.
MiR-129-5p alleviates myocardial injury by targeting suppressor of cytokine signaling 2 after ischemia/reperfusion.
Title: MiR-129-5p alleviates myocardial injury by targeting suppressor of cytokine signaling 2 after ischemia/reperfusion.
Suppressor of cytokine signaling 2 is induced in Huntington's disease and involved in autophagy.
Title: Suppressor of cytokine signaling 2 is induced in Huntington's disease and involved in autophagy.
SOCS2 Silencing Improves Somatic Growth without Worsening Kidney Function in CKD.
Title: SOCS2 Silencing Improves Somatic Growth without Worsening Kidney Function in CKD.

Submit: New GeneRIF Correction See all GeneRIFs (64)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (4)
Spontaneous (1) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC298718P2 (e-PCR)
- UniSTS:272457

AW108012 (e-PCR)
- UniSTS:180107

AI527257 (e-PCR)
- UniSTS:180108

NoName (e-PCR)
- UniSTS:236444

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth hormone receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin-like growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphorylation-dependent protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of cell surface receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in growth hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in growth hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lactation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lactation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland alveolus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mammary gland alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of growth hormone receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul5-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: suppressor of cytokine signaling 2

Names: CIS-2; STAT-induced STAT inhibitor 2; cytokine inducible SH2-containing protein 2; cytokine-inducible SH2 protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168655.1 → NP_001162126.1 suppressor of cytokine signaling 2

See identical proteins and their annotated locations for NP_001162126.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.

Source sequence(s)

AC167222, AK137403

Consensus CDS

CCDS24136.1

UniProtKB/Swiss-Prot

O35717

UniProtKB/TrEMBL

Q548Q7

Related

ENSMUSP00000129331.2, ENSMUST00000170690.8

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
NM_001168656.1 → NP_001162127.1 suppressor of cytokine signaling 2

See identical proteins and their annotated locations for NP_001162127.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.

Source sequence(s)

AC167222, AK137403

Consensus CDS

CCDS24136.1

UniProtKB/Swiss-Prot

O35717

UniProtKB/TrEMBL

Q548Q7

Related

ENSMUSP00000131875.2, ENSMUST00000172070.8

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
NM_001168657.1 → NP_001162128.1 suppressor of cytokine signaling 2

See identical proteins and their annotated locations for NP_001162128.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.

Source sequence(s)

AC167222, AK137403

Consensus CDS

CCDS24136.1

UniProtKB/Swiss-Prot

O35717

UniProtKB/TrEMBL

Q548Q7

Related

ENSMUSP00000113378.2, ENSMUST00000119917.2

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
NM_007706.4 → NP_031732.1 suppressor of cytokine signaling 2

See identical proteins and their annotated locations for NP_031732.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.

Source sequence(s)

AC167222, AK137403, BY069559

Consensus CDS

CCDS24136.1

UniProtKB/Swiss-Prot

O35717

UniProtKB/TrEMBL

Q548Q7

Related

ENSMUSP00000020215.10, ENSMUST00000020215.16

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

95219765..95253176 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313899.3 → XP_017169388.1 suppressor of cytokine signaling 2 isoform X1

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cl02533
Location:158 → 197

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_017313896.3 → XP_017169385.1 suppressor of cytokine signaling 2 isoform X1

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cl02533
Location:158 → 197

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_011243406.3 → XP_011241708.1 suppressor of cytokine signaling 2 isoform X2

See identical proteins and their annotated locations for XP_011241708.1

UniProtKB/TrEMBL

F6RVG2

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cl02533
Location:158 → 197

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_017313897.2 → XP_017169386.1 suppressor of cytokine signaling 2 isoform X1

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cl02533
Location:158 → 197

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_017313898.2 → XP_017169387.1 suppressor of cytokine signaling 2 isoform X1

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cl02533
Location:158 → 197

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_017313900.1 → XP_017169389.1 suppressor of cytokine signaling 2 isoform X1

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cl02533
Location:158 → 197

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_030245030.2 → XP_030100890.1 suppressor of cytokine signaling 2 isoform X7

UniProtKB/Swiss-Prot

O35717

UniProtKB/TrEMBL

Q548Q7

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
XM_036155751.1 → XP_036011644.1 suppressor of cytokine signaling 2 isoform X7

UniProtKB/Swiss-Prot

O35717

UniProtKB/TrEMBL

Q548Q7

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
XM_011243410.4 → XP_011241712.1 suppressor of cytokine signaling 2 isoform X7

See identical proteins and their annotated locations for XP_011241712.1

UniProtKB/Swiss-Prot

O35717

UniProtKB/TrEMBL

Q548Q7

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
XM_036155752.1 → XP_036011645.1 suppressor of cytokine signaling 2 isoform X7

UniProtKB/Swiss-Prot

O35717

UniProtKB/TrEMBL

Q548Q7

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
XM_036155753.1 → XP_036011646.1 suppressor of cytokine signaling 2 isoform X7

UniProtKB/Swiss-Prot

O35717

UniProtKB/TrEMBL

Q548Q7

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
XM_017313902.3 → XP_017169391.1 suppressor of cytokine signaling 2 isoform X6

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
XM_036155750.1 → XP_036011643.1 suppressor of cytokine signaling 2 isoform X5

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cl02533
Location:158 → 198

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_006513515.5 → XP_006513578.1 suppressor of cytokine signaling 2 isoform X3

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
XM_017313901.3 → XP_017169390.1 suppressor of cytokine signaling 2 isoform X4

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
XM_030245028.1 → XP_030100888.1 suppressor of cytokine signaling 2 isoform X2

UniProtKB/TrEMBL

F6RVG2

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cl02533
Location:158 → 197

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_006513517.5 → XP_006513580.1 suppressor of cytokine signaling 2 isoform X4

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...