Ube2d2b ubiquitin-conjugating enzyme E2D 2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ube2d2bprovided by MGI
Official Full Name: ubiquitin-conjugating enzyme E2D 2Bprovided by MGI
Primary source: MGI:MGI:1920568
See related: Ensembl:ENSMUSG00000063447 AllianceGenome:MGI:1920568
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700013N18Rik
Summary: Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase activity. Predicted to be involved in protein K11-linked ubiquitination and protein K48-linked ubiquitination. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human UBE2D2 (ubiquitin conjugating enzyme E2 D2) and UBE2D3 (ubiquitin conjugating enzyme E2 D3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 5 F; 5 52.23 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (107978028..107979643)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (107830162..107831777)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein K11-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K11-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K27-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K29-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K6-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2 D2B

Names: E2 ubiquitin-conjugating enzyme D2B; ubiquitin carrier protein D2B; ubiquitin-protein ligase D2B

NP_001263326.1

EC 2.3.2.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276397.1 → NP_001263326.1 ubiquitin-conjugating enzyme E2 D2B

See identical proteins and their annotated locations for NP_001263326.1

Status: VALIDATED

Source sequence(s)

AC138666

Consensus CDS

CCDS71632.1

UniProtKB/Swiss-Prot

Q6ZWY6

UniProtKB/TrEMBL

Q3U5V6, Q9D1S1

Related

ENSMUSP00000072387.7, ENSMUST00000072578.8

Conserved Domains (1) summary

cl00154
Location:1 → 146

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

107978028..107979643

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_028502.2: Suppressed sequence

Description

NM_028502.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
NR_003639.1: Suppressed sequence

Description

NR_003639.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.