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    ND-B15 NADH dehydrogenase (ubiquinone) B15 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36640, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ND-B15provided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) B15 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033961
    Locus tag
    Dmel_CG12859
    See related
    AllianceGenome:FB:FBgn0033961
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe3B12; CG 12859; CG12859; Dmel\CG12859; dNDUFB4; NB5M; NDUFB4; Q6IDF5
    Summary
    Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Orthologous to human NDUFB4 (NADH:ubiquinone oxidoreductase subunit B4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See ND-B15 in Genome Data Viewer
    Location:
    51C2-51C2; 2-72 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14756516..14757072)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10644021..10644577)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Regulatory particle non-ATPase 6 Neighboring gene uncharacterized protein Neighboring gene aveugle Neighboring gene TRAPP subunit 31 Neighboring gene uncharacterized protein Neighboring gene Sprouty-related protein with EVH-1 domain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex. Ebanks B, et al. Int J Mol Sci, 2021 Oct 27. PMID 34769041, Free PMC Article
    2. The membrane domain of respiratory complex I accumulates during muscle aging in Drosophila melanogaster. Hossain KFB, et al. Sci Rep, 2022 Dec 27. PMID 36575244, Free PMC Article
    3. Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state. Padavannil A, et al. Elife, 2023 Mar 23. PMID 36952377, Free PMC Article
    4. Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster. Agip AA, et al. Elife, 2023 Jan 9. PMID 36622099, Free PMC Article
    5. Genomic organization of gypsy chromatin insulators in Drosophila melanogaster. Ramos E, et al. Genetics, 2006 Apr. PMID 16452134, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) B15 subunit
    Names
    CG12859-PA
    NADH ubiquinone oxidoreductase B15
    NADH-ubiquinone oxidoreductase B15 subunit
    NADH:ubiquinone oxidoreductase B15 subunit
    ND-B15-PA
    anon-fast-evolving-3B12

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14756516..14757072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137141.5 → NP_610985.1  NADH dehydrogenase (ubiquinone) B15 subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610985.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IDF5
      Related
      FBpp0086570
      Conserved Domains (1) summary
      pfam07225
      Location:21 → 111
      NDUF_B4; NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IDF5 Q6IDF5

    Gene LinkOut

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