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    CG8569 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36376, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CG8569provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033752
    Locus tag
    Dmel_CG8569
    See related
    AllianceGenome:FB:FBgn0033752
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8569
    Summary
    Predicted to enable methylated histone binding activity. Predicted to be located in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 30. Orthologous to human ZMYND11 (zinc finger MYND-type containing 11). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG8569 in Genome Data Viewer
    Location:
    49A10-49A10; 2-67 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12519166..12521624)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8406671..8409129)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene achintya Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene frazzled Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cis-regulatory-directed pipeline for the identification of genes involved in cardiac development and disease. Nim HT, et al. Genome Biol, 2021 Dec 15. PMID 34906219, Free PMC Article
    2. DEAF-1 function is essential for the early embryonic development of Drosophila. Veraksa A, et al. Genesis, 2002 Jun. PMID 12112874
    3. Functional genomic analysis of the periodic transcriptome in the developing Drosophila wing. Liang L, et al. Dev Cell, 2014 Apr 14. PMID 24684830
    4. The genetic makeup of the Drosophila piRNA pathway. Handler D, et al. Mol Cell, 2013 Jun 6. PMID 23665231, Free PMC Article
    5. A Drosophila protein-interaction map centered on cell-cycle regulators. Stanyon CA, et al. Genome Biol, 2004. PMID 15575970, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8569-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12519166..12521624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136951.3 → NP_610795.1  uncharacterized protein Dmel_CG8569 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610795.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K264
      Related
      FBpp0087051
      Conserved Domains (4) summary
      cd05841
      Location:366 → 451
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05492
      Location:243 → 350
      Bromo_ZMYND11; Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene ...
      pfam01753
      Location:570 → 604
      zf-MYND; MYND finger
      cl22851
      Location:85 → 120
      PHD_SF; PHD finger superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K264 Q7K264

    Gene LinkOut

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