U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Sec71 Secretory 71 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34785, updated on 10-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sec71provided by FlyBase
    Official Full Name
    Secretory 71provided by FlyBase
    Primary source
    FLYBASE:FBgn0028538
    Locus tag
    Dmel_CG7578
    See related
    AllianceGenome:FB:FBgn0028538
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS00797.7; BIG1; CG7578; Dmel\CG7578; sec71
    Summary
    Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in Golgi to plasma membrane protein transport; positive regulation of endocytosis; and positive regulation of neuron remodeling. Located in trans-Golgi network. Is expressed in adult head. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to several human genes including ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sec71 in Genome Data Viewer
    Location:
    34D1-34D1; 2-49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13793521..13799674)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13793521..13799674)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44847 Neighboring gene Engulfment ABC Transporter in the ovary Neighboring gene uncharacterized protein Neighboring gene Carbonic anhydrase 1 Neighboring gene Adenosine deaminase, tRNA-specific 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Sec71 separates Golgi stacks in Drosophila S2 cells. Fujii S, et al. J Cell Sci, 2020 Dec 29. PMID 33262309, Free PMC Article
    2. Phylogenetic analysis of Sec7-domain-containing Arf nucleotide exchangers. Cox R, et al. Mol Biol Cell, 2004 Apr. PMID 14742722, Free PMC Article
    3. Sec71 functions as a GEF for the small GTPase Arf1 to govern dendrite pruning of Drosophila sensory neurons. Wang Y, et al. Development, 2017 May 15. PMID 28420712
    4. The Arf family G protein Arl1 is required for secretory granule biogenesis in Drosophila. Torres IL, et al. J Cell Sci, 2014 May 15. PMID 24610947, Free PMC Article
    5. GBF1 (Gartenzwerg)-dependent secretion is required for Drosophila tubulogenesis. Wang S, et al. J Cell Sci, 2012 Jan 15. PMID 22302994

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ARF protein signal transduction IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in Golgi to plasma membrane protein transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron remodeling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    secretory 71
    Names
    CG7578-PA
    Sec71 ortholog
    Sec71-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13793521..13799674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135831.3 → NP_609675.2  secretory 71 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609675.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NKE8, Q9VJW1
      Related
      FBpp0080114
      Conserved Domains (5) summary
      PLN03076
      Location:13 → 1580
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
      pfam01369
      Location:582 → 767
      Sec7; Sec7 domain
      pfam09324
      Location:1080 → 1161
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:312 → 465
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16213
      Location:30 → 212
      DCB; Dimerization and cyclophilin-binding domain of Mon2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJW1 Q9VJW1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools